4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL ESTER

Product Name: 4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL ESTER
CAS No.: 128577-47-9
Chemical Name: 4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL ESTER
Synonyms: -3-fluorobenzoate;4-(bromomethyl)-3-fluorobenzoic acid;Methyl 4-bromomethyl-3-fluorobenzoat;Methyl 4-broMoMethyl-3-fluorobenzoate;MMETHYL 4-(BROMOMETHYL)-3-FLUOROBENZOATE;4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL;4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL ESTER;Methyl 4-(bromomethyl)-3-fluorobenzoate, 98%min;Benzoicacid, 4-(bromomethyl)-3-fluoro-, methyl ester
CBNumber: CB4176505
Molecular Formula: C9H8BrFO2
Formula Weight: 247.06
MOL File: 128577-47-9.mol

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4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL ESTER Property

Melting point:: 68 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
Boiling point:: 295.1±35.0 °C(Predicted)
Density: 1.534±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
color: White

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M296275
Product name: Methyl4-(bromomethyl)-3-fluorobenzoate
Packaging: 500mg
Price: $125
Updated: 2021/12/16

TRC

Product number: M296275
Product name: Methyl4-(bromomethyl)-3-fluorobenzoate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB30701
Product name: 4-Bromomethyl-3-fluorobenzoic acid methyl ester
Packaging: 250mg
Price: $125
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2723-B-21
Product name: Methyl 4-(bromomethyl)-3-fluorobenzoate
Packaging: 5G
Price: $984
Updated: 2021/12/16

AK Scientific

Product number: Z4066
Product name: Methyl4-(bromomethyl)-3-fluorobenzoate
Packaging: 10g
Price: $416
Updated: 2021/12/16

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4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 4-(bromomethyl)-3-fluorobenzoate

Synthesis

87808-48-8

128577-47-9

Bromination reaction: Methyl 3-fluoro-4-methylbenzoate (18.3 mmol) was dissolved with N-bromosuccinimide (NBS, 3.9 g, 22 mmol) in carbon tetrachloride (40 mL), and benzoyl peroxide (0.55 g, 1.7 mmol) containing 25% water was added as initiator. The reaction mixture was stirred well and heated to reflux for 6 hours. Upon completion of the reaction, the solvent was removed by evaporation and the residue was treated with an aqueous solution of potassium carbonate (K2CO3) followed by extraction of the product with ethyl acetate (EtOAc). After treatment, methyl 3-fluoro-4-(bromomethyl)benzoate was obtained as a light yellow solid in a yield of 5.9 g. The product was analyzed by electrospray ionization mass spectrometry (ESI-MS), which showed the [M + H]+ peak as 247 Da.

References

[1] Patent: WO2014/102376, 2014, A1. Location in patent: Page/Page column 45
[2] Patent: WO2014/102377, 2014, A1. Location in patent: Page/Page column 49-50
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 15, p. 6058 - 6080
[4] Synlett, 2014, vol. 25, # 17, p. 2485 - 2487
[5] Patent: US2006/14945, 2006, A1. Location in patent: Page/Page column 60

4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL ESTER Suppliers

China 92 Germany 1 India 1 United Kingdom 2 United States 12 Global 108

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128577-47-9, 4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL ESTERRelated Search:

4-(Bromomethyl)phenylaceticacidphenacylester 4-(ISOCYANOMETHYL)BENZOIC ACID METHYL ESTER Methyl 4-trifluoromethylbenzoate METHYL (4-HYDROXYMETHYL)BENZOATE Methyl 3-(Bromomethyl)-4-chlorobenzoate Methyl 3-fluoro-4-forMylbenzoate METHYL 4-(BROMOMETHYL)-3-CHLOROBENZOATE Methyl 4-(bromomethyl)benzoate Methyl-4-(4-Fluorophenyl)-4-oxobutanoate 4-Bromomethyl-2,6-difluoro-benzoic acid methyl ester METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE Methyl 4-chlorocarbonylbenzoate 3-Fluoro-4-methylbenzoic acid 2-FLUORO-4-METHYLBENZYL BROMIDE 4-(BROMOMETHYL)BENZALDEHYDE 4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL ESTER 4-Bromomethylbenzoic acid 4-Methylbenzyl bromide

4-(bromomethyl)-3-fluorobenzoic acid

Methyl 4-broMoMethyl-3-fluorobenzoate

Methyl 4-bromomethyl-3-fluorobenzoat

-3-fluorobenzoate

4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL

4-BROMOMETHYL-3-FLUOROBENZOIC ACID METHYL ESTER

MMETHYL 4-(BROMOMETHYL)-3-FLUOROBENZOATE

Benzoicacid, 4-(bromomethyl)-3-fluoro-, methyl ester

Methyl 4-(bromomethyl)-3-fluorobenzoate, 98%min

128577-47-9