4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 130636-61-2
Chemical Name: 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: BUTTPARK 36\08-67;1-Boc-4-(4-nitrobenzyl)piperazine;N2-{[(2-Methyl-2-Propanyl)Oxy]Carbonyl}-L-Glutamine;1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine;tert-butyl 4-[(4-nitrophenyl)Methyl]piperazine-1-carboxylate;4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%;4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylic acid tert-butyl ester;tert-butyl 4-[(4-nitrophenyl)methyl]piperazine-1-carboxylate - [AC77724];4-[(4-NITROPHENYL)METHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
CBNumber: CB4199461
Molecular Formula: C16H23N3O4
Formula Weight: 321.37
MOL File: 130636-61-2.mol

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4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Melting point:: 99-100 °C
Boiling point:: 436.5±40.0 °C(Predicted)
Density: 1.208±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.49±0.10(Predicted)
Appearance: White to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B656773
Product name: 1-Boc-4-(4-Nitrobenzyl)piperazine
Packaging: 250mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 071894
Product name: 1-Boc-4-(4-Nitrobenzyl)piperazine
Purity: 95+%
Packaging: 1g
Price: $278
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0002708
Product name: 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 250MG
Price: $187.95
Updated: 2021/12/16

AK Scientific

Product number: X9773
Product name: 1-Boc-4-(4-Nitrobenzyl)piperazine
Packaging: 25g
Price: $717
Updated: 2021/12/16

Matrix Scientific

Product number: 071894
Product name: 1-Boc-4-(4-Nitrobenzyl)piperazine
Purity: 95+%
Packaging: 5g
Price: $759
Updated: 2021/12/16

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4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

100-11-8

57260-71-6

130636-61-2

General procedure for the synthesis of tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate from 4-nitrobenzyl bromide and N-BOC-piperazine: Potassium carbonate (3 g) was added to a solution containing tert-butyl 1-piperazinecarboxylate (0.74 g, 4 mmol) and 4-nitrobenzyl bromide (0.86 g, 4 mmol) in N,N-dimethylformamide (DMF, 5 mL). The reaction mixture was stirred at room temperature for 4 hours. After the reaction was completed, the product was extracted with ethyl acetate (50 mL) and the organic phase was washed with water (20 mL x 3). The organic layer was dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography using ethyl acetate as eluent to afford the target compound tert-butyl 4-(4-nitrobenzyl)-1-piperazinecarboxylate (3) (1.22 g, 95% yield) with a melting point of 99-100 °C. 1H NMR (DMSO-d6) data were as follows: δ 8.21-8.19 (d, 2H, J = 8.8 Hz, Ar-H), 7.61 -7.59 (d, 2H, J = 8.0 Hz, Ar-H), 3.63 (s, 2H, CH2), 3.34-3.30 (m, 4H, partially fuzzy, 2 × CH2), 2.35-2.32 (m, 4H, 2 × CH2), 1.39 (s, 9H, 3 × CH3). Elemental analysis (C16H23N3O4) results are consistent with calculated values.

References

[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 19, p. 5592 - 5599
[2] Patent: US2004/34033, 2004, A1. Location in patent: Page/Page column 12; Sheet 1
[3] Patent: US2007/249649, 2007, A1. Location in patent: Page/Page column 116
[4] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 120
[5] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 122

4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 48 Germany 1 India 1 United Kingdom 5 United States 11 Global 66

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View Lastest Price from 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 130636-61-2
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-13

130636-61-2, 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

4-(4-NITRO-BENZYL)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER HYDROCHLORIDE 4-[CARBOXY-(4-NITRO-PHENYL)-METHYL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 4-(4-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-[(4-NITROPHENYL)METHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

BUTTPARK 36\08-67

tert-butyl 4-[(4-nitrophenyl)Methyl]piperazine-1-carboxylate

1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine

4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%

1-Boc-4-(4-nitrobenzyl)piperazine

4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylic acid tert-butyl ester

1-Piperazinecarboxylic acid, 4-[(4-nitrophenyl)methyl]-, 1,1-dimethylethyl ester

N2-{[(2-Methyl-2-Propanyl)Oxy]Carbonyl}-L-Glutamine

tert-butyl 4-[(4-nitrophenyl)methyl]piperazine-1-carboxylate - [AC77724]

130636-61-2

API intermediates