2-Amino-4-hydroxy-6-phenylpyrimidine
- Product Name
- 2-Amino-4-hydroxy-6-phenylpyrimidine
- CAS No.
- 56741-94-7
- Chemical Name
- 2-Amino-4-hydroxy-6-phenylpyrimidine
- Synonyms
- NSC42141;NSC212187;T0515-8624;ZINC00040022;ZINC04555874;Oprea1_175017;AF-936/31346025;ChemDiv2_000111;BUTTPARK 44\01-63;6-Phenylisocytosine
- CBNumber
- CB4203991
- Molecular Formula
- C10H9N3O
- Formula Weight
- 187.2
- MOL File
- 56741-94-7.mol
2-Amino-4-hydroxy-6-phenylpyrimidine Property
- Melting point:
- 295 °C
- Boiling point:
- 374.5±45.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 9.15±0.50(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 56741-94-7(CAS DataBase Reference)
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P2123
- Product name
- 6-Phenylisocytosine
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $105
- Updated
- 2025/07/31
- Product number
- P2123
- Product name
- 6-Phenylisocytosine
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $315
- Updated
- 2025/07/31
- Product number
- A612465
- Product name
- 2-Amino-4-hydroxy-6-phenylpyrimidine
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- Q460
- Product name
- 2-Amino-4-hydroxy-6-phenylpyrimidine
- Packaging
- 5g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 066110
- Product name
- 2-Amino-6-phenylpyrimidin-4(3H)-one
- Packaging
- 500mg
- Price
- $237
- Updated
- 2021/12/16
2-Amino-4-hydroxy-6-phenylpyrimidine Chemical Properties,Usage,Production
Uses
2-Amino-4-hydroxy-6-phenylpyrimidine has been utilized in the investigation of 2-aminopyrimidines as potential non-natural nucleobase analogues.
Synthesis
94-02-0
56741-94-7
Intermediate 1A: Preparation of 4-chloro-6-phenylpyrimidin-2-amine; Guanidine carbonate (3.60 g, 20 mmol) was suspended in ethanol (120 mL) and toluene (20 mL) and refluxed under nitrogen protection for 1 hour, during which time about 50 mL of solvent was removed by distillation. After the mixture was cooled to 45 °C, ethyl 3-oxo-3-phenylpropionate (7.68 g, 40 mmol) was added and refluxing was continued with heat overnight. During the reaction, the target product precipitated as a white solid. Water (50 mL) was added and reflux was continued for 30 minutes. After cooling to room temperature, the reaction mixture was neutralized with 1N HCl and allowed to stand in a refrigerator for 6 hours. The solid was collected by filtration, washed sequentially with water and ether, and dried under vacuum at 60 °C to give a white solid product (6.45 g, 86% yield). Mass spectrometry (MS ES): m/z 188 ([M + H]+, calculated value 188); measured value: 188. retention time (RT) = 0.91 min; thin-layer chromatography (TLC, unfolding reagent was 95/5 MeOH solution of CH2Cl2/2M NH3) Rf = 0.10. The above product (6.0 g, 32 mmol) was mixed with POCl3 (100 mL) was mixed and heated to reflux for 1 hr. Decompression distillation removed most of the POCl3 and the residue was diluted with EtOAc and poured into ice/saturated NaHCO3 solution. The aqueous layer was extracted with EtOAc, the organic layers were combined, washed with brine, dried over anhydrous Na2SO4 and concentrated. The crude product was recrystallized by EtOAc/ether to give the off-white powdery product 1A (2.8 g, 43% yield). Mass spectrometry analysis (MS ES): m/z 206 ([M + H]+, calculated value 206); retention time (RT) = 2.49 min; thin-layer chromatography (TLC, unfolding agent is 95/5 MeOH solution of CH2Cl2/2M NH3) Rf = 0.72. (Ref. 1: H.L. Skulnick, S.D. Weed, E.E. Edison, H.E. Renis, W. Wierenga, and D.A. Stringfellow, J. Med. Chem. 1985, 28, 1854-1869).
References
[1] Patent: WO2005/35507, 2005, A2. Location in patent: Page/Page column 52
2-Amino-4-hydroxy-6-phenylpyrimidine Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Amino-4-hydroxy-6-phenylpyrimidine manufacturers
- Product
- 2-Amino-4-hydroxy-6-phenylpyrimidine 56741-94-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-17
- Product
- 2-Amino-4-hydroxy-6-phenylpyrimidine 56741-94-7
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-18