6-CHLORO-9-METHYLPURINE

Product Name: 6-CHLORO-9-METHYLPURINE
CAS No.: 2346-74-9
Chemical Name: 6-CHLORO-9-METHYLPURINE
Synonyms: 6-CHLORO-9-METHYL-9H-PURINE;NSC 4948;AKOS BBS-00003131;IFLAB-BB F1371-0159;OTAVA-BB BB7216640145;9-METHYL-6-CHLOROPURINE;6-CHLORO-9-METHYLPURINE;9H-Purine, 6-chloro-9-methyl-;8a-(2,4-dimethylphenyl)-3,4,7,8-tetrahydro-2H-pyrrolo[2,1-b][1,3]oxazin-6-one
CBNumber: CB4223083
Molecular Formula: C6H5ClN4
Formula Weight: 168.58
MOL File: 2346-74-9.mol

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6-CHLORO-9-METHYLPURINE Property

Melting point:: 129-134oC
Boiling point:: 321.7±45.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 1.26±0.10(Predicted)
color: Off-White
CAS DataBase Reference: 2346-74-9(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C369500
Product name: 6-Chloro-9-methylpurine
Packaging: 100mg
Price: $110
Updated: 2021/12/16

Usbiological

Product number: C5028-60C
Product name: 6-Chloro-9-methylpurine
Packaging: 100mg
Price: $403
Updated: 2021/12/16

Usbiological

Product number: 295628
Product name: 6-Chloro-9-methylpurine
Packaging: 50mg
Price: $432
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NC11301
Product name: 6-Chloro-9-methylpurine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NC11301
Product name: 6-Chloro-9-methylpurine
Packaging: 100mg
Price: $95
Updated: 2021/12/16

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6-CHLORO-9-METHYLPURINE Chemical Properties,Usage,Production

Chemical Properties

6-CHLORO-9-METHYLPURINE is Pale Yellow Solid

Uses

6-CHLORO-9-METHYLPURINE is a useful synthetic intermediate

Uses

A useful synthetic intermediate.

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 490, 1957 DOI: 10.1021/ja01559a069

Synthesis

87-42-3

74-88-4

2346-74-9

To a solution of 6-chloro-9H-purine (3.00 g, 20.0 mmol) in anhydrous THF (100 mL) cooled to 0°C was added 60% sodium hydride (1.2 g, 30.0 mmol) in portions. The reaction mixture was stirred in an ice bath for 0.5 h. Then iodomethane (2.82 g, 20.0 mmol) was slowly added and stirring was continued for 1 h at room temperature. After completion of the reaction, the mixture was diluted with 100 mL of water and extracted with ethyl acetate (30 mL x 3). The organic layers were combined, dried with anhydrous magnesium chloride and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent being a 20% ethyl acetate/petroleum ether solvent mixture. The white solid product 9-methyl-6-chloropurine was obtained in 74.6% (2.50 g) yield. The product was analyzed by ESI-MS, m/z: 169.1 [M + H]+; 1H NMR (300 MHz, DMSO-d6) δ: 3.72 (3H, s, CH3), 8.72 (1H, s, H-purine), 9.15 (1H, s, H-purine).

References

[1] European Journal of Medicinal Chemistry, 2014, vol. 89, p. 581 - 596
[2] Synthesis, 2007, # 2, p. 219 - 224
[3] Angewandte Chemie - International Edition, 2018, vol. 57, # 18, p. 5134 - 5138
[4] Angew. Chem., 2018, vol. 130, # 18, p. 5228 - 5232,5
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 1, p. 139 - 149

6-CHLORO-9-METHYLPURINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-CHLORO-9-METHYLPURINE Suppliers

Canada 2 China 76 France 1 Germany 3 India 2 The Netherlands 1 Ukraine 1 United Kingdom 4 United States 16 Global 106

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View Lastest Price from 6-CHLORO-9-METHYLPURINE manufacturers

Career Henan Chemical Co

Product: 6-CHLORO-9-METHYLPURINE 2346-74-9
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-24

2346-74-9, 6-CHLORO-9-METHYLPURINERelated Search:

2,6-Dichloropurine-2'-deoxyriboside 6-CHLORO-9-(TETRAHYDRO-2-PYRANYL)-PURINE 6-Chloropurine ribonucleoside 6-CHLOROPURINE-2'-DEOXYRIBOSIDE 6-Chloropurine 2-Amino-6-chloropurine Riboside 6-CHLORO-5'-O-(DIMETHOXYTRITYL)PURINE-2'-DEOXYRIBOSIDE 2-AMINO-6-CHLORO-9-(BETA-D-2-DEOXYRIBOFURANOSYL)PURINE 2,6-DICHLORO-9-METHYL-9H-PURINE 6-chloro-9-cyclopentyl-9H-purine 2-AMINO-6-CHLORO-9H-PURINE-9-ACETIC ACID 6-CHLOROPURINE GLUCOSIDE 9-BENZYL-6-CHLORO-9H-PURINE 6-CHLORO-9-(3,5-O-DI(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURANOSYL) PURINE 6-CHLORO-9-METHYLPURINE 9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE 6-CHLORO-7-METHYLPURINE 6-AMINO-2-CHLORO-7-METHYLPURINE

OTAVA-BB BB7216640145

6-CHLORO-9-METHYL-9H-PURINE

6-CHLORO-9-METHYLPURINE

9-METHYL-6-CHLOROPURINE

8a-(2,4-dimethylphenyl)-3,4,7,8-tetrahydro-2H-pyrrolo[2,1-b][1,3]oxazin-6-one

AKOS BBS-00003131

IFLAB-BB F1371-0159

NSC 4948

9H-Purine, 6-chloro-9-methyl-

2346-74-9

pharmacetical

Nucleotides and Nucleosides

Bases & Related Reagents

Nucleotides