Tellimagrandin II

Product Name: Tellimagrandin II
CAS No.: 81571-72-4
Chemical Name: Tellimagrandin II
Synonyms: Aids070905;Aids-070905;Tellimagrandin 2;Tellimagrandin II;Tellimagrandin II (Synonyms: Eugeniin);1-O,2-O,3-O-Trigalloyl-4-O,6-O-(2,2',3,3',4,4'-hexahydroxy[1,1'-biphenyl]-6,6'-diylbiscarbonyl)-β-D-glucopyranose;1-O,2-O,3-O-Trigalloyl-4-O,6-O-[2,2',3,3',4,4'-hexahydroxy[1,1'-biphenyl]-6,6'-diylbis(carbonyl)]-β-D-glucopyranose;4-O,6-O-[(4,4',5,5',6,6'-Hexahydroxy-1,1'-biphenyl-2,2'-diyl)bis(carbonyl)]-1-O,2-O,3-O-trigalloyl-β-D-glucopyranose;β-D-Glucopyranose, cyclic 4,6-[(1S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1,2,3-tris(3,4,5-trihydroxybenzoate);.beta.-D-Glucopyranose, cyclic 4,6-[(1S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1,2,3-tris(3,4,5-trihydroxybenzoate)
CBNumber: CB42292032
Molecular Formula: C41H30O26
Formula Weight: 938.66
MOL File: 81571-72-4.mol

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Tellimagrandin II Property

Boiling point:: 1503.7±65.0 °C(Predicted)
Density: 2.13±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
pka: 7.50±0.70(Predicted)
form: Solid
color: Off-white to light yellow
LogP: 3.138 (est)

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Hazard and Precautionary Statements (GHS)

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Tellimagrandin II Chemical Properties,Usage,Production

Uses

Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from 4C1-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases[1][2][3][4].

Biological Activity

Tellimagrandin II (Eugeniin), the first intermediate in the 4C1-glucose derived series of ellagitannins, also inhibits antibiotic resistance of drug-resistant Staphylococcus aureus[1][2].

in vivo

Tellimagrandin II (100 and 200 mg/kg, p.o., once daily for 10 days) improved learning and memory functions in Scopolamine (HY-N0296)-induced amnesiac ICR mice^[4].

Animal Model:	Scopolamine (HY-N0296)-induced amnesiac ICR mouse model^[4]
Dosage:	100 and 200 mg/kg
Administration:	Oral gavage (p.o.), once daily for 10 days
Result:	Improved learning and memory functions in the passive avoidance and water maze tests.

References

[1]. Ruth Niemetz, et al. Oxidation of pentagalloylglucose to the ellagitannin, tellimagrandin II, by a phenol oxidase from Tellima grandiflora leaves. Phytochemistry. 2003 Feb;62(3):301-6. [2]. Yu-Wei Chang, et al. Tellimagrandin II, A Type of Plant Polyphenol Extracted from Trapa bispinosa Inhibits Antibiotic Resistance of Drug-Resistant Staphylococcus aureus. Int J Mol Sci. 2019 Nov 18;20(22):5790.

Tellimagrandin II Preparation Products And Raw materials

Raw materials

Preparation Products

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81571-72-4, Tellimagrandin IIRelated Search:

1-O,2-O,3-O-Trigalloyl-4-O,6-O-(2,2',3,3',4,4'-hexahydroxy[1,1'-biphenyl]-6,6'-diylbiscarbonyl)-β-D-glucopyranose

1-O,2-O,3-O-Trigalloyl-4-O,6-O-[2,2',3,3',4,4'-hexahydroxy[1,1'-biphenyl]-6,6'-diylbis(carbonyl)]-β-D-glucopyranose

4-O,6-O-[(4,4',5,5',6,6'-Hexahydroxy-1,1'-biphenyl-2,2'-diyl)bis(carbonyl)]-1-O,2-O,3-O-trigalloyl-β-D-glucopyranose

Tellimagrandin 2

Tellimagrandin II

.beta.-D-Glucopyranose, cyclic 4,6-[(1S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1,2,3-tris(3,4,5-trihydroxybenzoate)

Aids070905

Aids-070905

β-D-Glucopyranose, cyclic 4,6-[(1S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1,2,3-tris(3,4,5-trihydroxybenzoate)

Tellimagrandin II (Synonyms: Eugeniin)

81571-72-4