ChemicalBook > CAS DataBase List > Bis(3-methylsalicylic acid)1,1,3,3-tetrabutyl-1,3-distanna-2-oxapropane-1,3-diyl ester
Bis(3-methylsalicylic acid)1,1,3,3-tetrabutyl-1,3-distanna-2-oxapropane-1,3-diyl ester
- Product Name
- Bis(3-methylsalicylic acid)1,1,3,3-tetrabutyl-1,3-distanna-2-oxapropane-1,3-diyl ester
- CAS No.
- 1620951-72-5
- Chemical Name
- Bis(3-methylsalicylic acid)1,1,3,3-tetrabutyl-1,3-distanna-2-oxapropane-1,3-diyl ester
- Synonyms
- PA-1;PA1 2HCl;PA-1 2HCl,PA1 2HCl;Bis(3-methylsalicylic acid)1,1,3,3-tetrabutyl-1,3-distanna-2-oxapropane-1,3-diyl ester
- CBNumber
- CB42350909
- Molecular Formula
- C32H50O7Sn2
- Formula Weight
- 784.1552
- MOL File
- 1620951-72-5.mol
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Bis(3-methylsalicylic acid)1,1,3,3-tetrabutyl-1,3-distanna-2-oxapropane-1,3-diyl ester Property
- storage temp.
- -196°C
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Bis(3-methylsalicylic acid)1,1,3,3-tetrabutyl-1,3-distanna-2-oxapropane-1,3-diyl ester Chemical Properties,Usage,Production
Uses
PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively[1].
References
[1] Matthias Sch?nberger, et al. Controlling epithelial sodium channels with light using photoswitchable amilorides. Nat Chem. 2014 Aug;6(8):712-9. DOI:10.1038/nchem.2004
Bis(3-methylsalicylic acid)1,1,3,3-tetrabutyl-1,3-distanna-2-oxapropane-1,3-diyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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