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Amsacrine hydrochloride

Product Name
Amsacrine hydrochloride
CAS No.
54301-15-4
Chemical Name
Amsacrine hydrochloride
Synonyms
nsc141549;nci-c03190;M-AMSA, HCL;M-Amsacrine;Amsacrine HCI;META-AMSACRINE;AMSA hydrochloride;M-AMSA HYDROCHLORIDE;AMSACRINE HYDROCHLORIDE;acridinyl anisidide hydrochloride
CBNumber
CB4236395
Molecular Formula
C21H20ClN3O3S
Formula Weight
429.92
MOL File
54301-15-4.mol
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Amsacrine hydrochloride Property

Melting point:
197-199 °C(lit.)
storage temp. 
Refrigerator
solubility 
DMSO: 10 mg/mL with heat and sonication
form 
powder
color 
red to brown
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
PB1081000
HS Code 
2933.99.8290
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H341Suspected of causing genetic defects

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A9809
Product name
Amsacrine hydrochloride
Purity
≥98% (TLC), powder
Packaging
10mg
Price
$336
Updated
2024/03/01
Sigma-Aldrich
Product number
A9809
Product name
Amsacrine hydrochloride
Purity
≥98% (TLC), powder
Packaging
50mg
Price
$1220
Updated
2024/03/01
TCI Chemical
Product number
A2777
Product name
Amsacrine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
20mg
Price
$118
Updated
2024/03/01
TCI Chemical
Product number
A2777
Product name
Amsacrine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$349
Updated
2024/03/01
Cayman Chemical
Product number
22223
Product name
Amsacrine (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
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Amsacrine hydrochloride Chemical Properties,Usage,Production

Uses

Amsacrine hydrochloride has been used:

  • as a topoisomerase poison in bacteriophage T4 topoisomerase assay
  • as a topoisomerase inhibitor in Drosophila cell line, Kc167
  • as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts
  • as a topoisomerase II poison in dose-response assays in C elegans

Biological Activity

amsacrine hydrochloride (amsidine, m-amsa) is an inhibitor of topoisomerase 2 [1].amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia. in addition, amsacrine hydrochloride has shown the sensitivities to the cancer cell lines with the ic50 values of 190.2±27.4ng/ml, 46.1±3.9ng/ml,22.6±3.1ng/ml, 11.8±2.0ng/ml, 5.0±0.4ng/ml, and 11.7±1.5ng/ml for three bladder cancer cell lines (ht1376,rt112, rt4) and three testis cancer cell lines(833k, susa, gh), respectively. and it has been found that the testis tumor cell lines are more sensitive to inhibiting by amsacrine hydrochloride than the bladder cell lines [1].

Biochem/physiol Actions

Amsacrine (m-AMSA) is a derivative of acridine and an antileukemia drug. It is an anticancer drug with antineoplastic activity that targets topoisomerase II. AMSA is an apoptosis inducer and favors the accumulation of double-stranded breaks (DSBs). It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.

References

[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.

Amsacrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Amsacrine hydrochloride Suppliers

TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23662
Advantage
75
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View Lastest Price from Amsacrine hydrochloride manufacturers

Career Henan Chemical Co
Product
Amsacrine hydrochloride 54301-15-4
Price
US $1.00/g
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-09

54301-15-4, Amsacrine hydrochlorideRelated Search:


  • m-AMSA, 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride
  • Methanesulfone-m-anisidine-4'-[(9-acridinyl)amino] hydrochloride
  • Methanesulfon-m-anisidide 4'-(9-acridinylamino)-
  • Methansulfon-m-aniside, 4'-(9-acridinylamino)-, monohydrochloride
  • 4-[9-ACRIDINYLAMINO]-N-[METHANE-SULFONYL]-M-ANISIDINE HYDROCHLORIDE
  • M-AMSA HYDROCHLORIDE
  • M-AMSA, HCL
  • Methanesulfonamide, N-4-(9-acridinylamino)-3-methoxyphenyl-, monohydrochloride
  • M-Amsacrine
  • META-AMSACRINE
  • N-(4-(acridin-9-ylaMino)-3-Methoxyphenyl)MethanesulfonaMide hydrochloride
  • MethanesulfonaMide,N-[4-(9-acridinylaMino)-3-Methoxyphenyl]-, hydrochloride (1:1)
  • AMine hydrochloride benzene acridine
  • AMSACRINE HYDROCHLORIDE
  • nsc141549
  • AMSA hydrochloride
  • Amsacrine Hydrochloride, 4-(9-Acridinylamino)-N-(Methanesulfonyl)-M-Anisidine Hydrochloride
  • Amsacrine hydrochloride, ≥98% (HPLC)
  • 4’-((9-acridinyl)amino)-methanesulfon-m-anisidinhydrochloride
  • 4’-(9-acridinylamino)methanesulfon-m-anisidemonohydrochloride
  • 4’-(9-acridinylamino)-methanesulfon-m-anisididmonohydrochloride
  • 4’-(9-acridinylamino)-methanesulfonyl-m-anisidinmonohydrochloride
  • n-(4-(9-acridinylamino)-3-methoxyphenyl)-methanesulfonamidmonohydrochlor
  • nci-c03190
  • acridinyl anisidide hydrochloride
  • Amsacrine HCI
  • 54301-15-4
  • C21H19N3O3S
  • C21H19N3O3SHCl
  • Apoptosis and Cell Cycle
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • DNA metabolism
  • DNA Repair Regulators