OLANEXIDINE

Product Name: OLANEXIDINE
CAS No.: 146510-36-3
Chemical Name: OLANEXIDINE
Synonyms: OLANEXIDINE;Olanexidine-008;Olanexidine [inn];Olanexidine-008-HCl;Olanexidine Gluconate;Olanexidine Impurity 11;N1-(3,4-Dichlorobenzyl)-N5-octylbiguanide;N''-(3,4-dichlorobenzyl)-N'''-octylimidodicarbonimidic diamide;N''-(3,4-dichlorobenzyl)-N'''-octylimidodicarbonimidic diami...;1-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]-2-octylguanidine
CBNumber: CB42451253
Molecular Formula: C17H27Cl2N5
Formula Weight: 372.34
MOL File: 146510-36-3.mol

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OLANEXIDINE Property

Boiling point:: 454.7±55.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
pka: 11.92±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0019384
Product name: OLANEXIDINE
Purity: 95.00%
Packaging: 5MG
Price: $503.79
Updated: 2021/12/16

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OLANEXIDINE Chemical Properties,Usage,Production

Description

In July 2015, olanexidine gluconate, a biguanide compound with remarkable antibacterial activity, was approved by the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan for skin antisepsis at surgical sites. The drug was developed and marketed by Otsuka Pharmaceutical in Japan and is available as topical solution (1.5%). Olanexidine gluconate exhibited efficacy against a wide range of bacterial strains, especially Grampositive bacteria. In vitro experiments exploring its mechanism of action indicated that olanexidine interacts with bacterial surface molecules (such as lipopolysaccharides and lipoteichoic acid), disrupting the cell membranes of liposomes. These models suggest that the drug permeates the membranes of both Escherichia coli and Staphylococcus aureus and denatures proteins at relatively high concentrations (>160 g/mL).

Definition

ChEBI: Olanexidine is a dichlorobenzene.

Synthesis

The synthesis of olanexidine gluconate is relatively straightforward, involving the linkage of an n-octyl side chain and a dichlorobenzylamine through a bis-guanidyl lynchpin. The synthesis began with the reaction of commercial noctylamine (17) with sodium dicyanamide in the presence of concentrated sulfuric acid in refluxing n-butyl acetate to give rise to 1-cyano-3-octylguanidine (18) in 86% yield . Conditions employed to subsequently secure biguanidine 20 as the HCl salt hemihydrate in 77% yield were nearly identical to those used for the conversion of 17 to 18. Finally, treatment of 20 with sodium hydroxide in the presence of gluconic acid (21) gave rise to olanexidin gluconate (II) in almost quantitative yield.

OLANEXIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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OLANEXIDINE Suppliers

China 21 United States 2 Global 23

Adamas Reagent, Ltd.

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Zhengzhou Acme Chemical Co., Ltd.

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Hefei TNJ Chemical Industry Co.,Ltd.

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Guangzhou Juntang Technology Co., Ltd

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QUALITY CONTROL SOLUTIONS LTD.

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Molcoo Chemicals Inc.

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Shanghai Haohong Scientific Co., Ltd.

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View Lastest Price from OLANEXIDINE manufacturers

Career Henan Chemica Co

Product: OLANEXIDINE 146510-36-3
Price: US $17.00/g
Min. Order: 1g
Purity: 95%
Supply Ability: 1KG
Release date: 2020-10-28

146510-36-3, OLANEXIDINERelated Search:

3,4-DICHLOROBENZYLAMINE HYDROCHLORIDE OLANEXIDINE intermediate Olanexidine Impurity 3 (3,4-Dichlorobenzyl)methylamine Olanexidine Impurity 2,3-Dichlorobenzylamine 3,4-Dichlorobenzylamine Oxiracetam Olanexidine Impurity 2,4-Dichlorobenzylamine (3,4-DICHLOROBENZYL)-GUANIDINE Poly(hexamethylenebiguanide) OLANEXIDINE

N''-(3,4-dichlorobenzyl)-N'''-octylimidodicarbonimidic diamide

1-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]-2-octylguanidine

Olanexidine Impurity 11

OLANEXIDINE

Imidodicarbonimidic diamide, N-((3,4-dichlorophenyl)methyl)-N'-octyl

Olanexidine [inn]

N-[(3,4-Dichlorophenyl)methyl]-N'-octylimidodicarbonimidic diamide

N1-(3,4-Dichlorobenzyl)-N5-octylbiguanide

Olanexidine Gluconate

Olanexidine-008-HCl

Olanexidine-008

N''-(3,4-dichlorobenzyl)-N'''-octylimidodicarbonimidic diami...

Imidodicarbonimidicdiamide,N-[(3,4-dichlorophenyl)methyl]-N'-octyl-

146510-36-3

C17H27Cl2N5