ChemicalBook > CAS DataBase List > TQS
TQS
- Product Name
- TQS
- CAS No.
- 353483-92-8
- Chemical Name
- TQS
- Synonyms
- TQS;TQS, 10 mM in DMSO;4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide;3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide;3H-Cyclopenta[c]quinoline-8-sulfonamide, 3a,4,5,9b-tetrahydro-4-(1-naphthalenyl)-;Inhibitor,modulator,acetylcholine,Nicotinic acetylcholine receptors,nAChR,allosteric,neuroinflammatory,positive,pain,inhibit,TQS,nicotinic
- CBNumber
- CB42535704
- Molecular Formula
- C22H20N2O2S
- Formula Weight
- 376.47
- MOL File
- 353483-92-8.mol
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TQS Property
- Boiling point:
- 609.8±65.0 °C(Predicted)
- Density
- 1.311±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble to 50 mM in DMSO
- form
- Powder
- pka
- 10.21±0.40(Predicted)
- color
- Off-white to light yellow
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML3316
- Product name
- TQS
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $89.39
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML3316
- Product name
- TQS
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $378
- Updated
- 2025/07/31
Tocris
- Product number
- 4233
- Product name
- TQS
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $152
- Updated
- 2021/12/16
Tocris
- Product number
- 4233
- Product name
- TQS
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $675
- Updated
- 2021/12/16
TRC
- Product number
- T700565
- Product name
- TQS
- Packaging
- 100mg
- Price
- $925
- Updated
- 2021/12/16
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TQS Chemical Properties,Usage,Production
Uses
TQS is a positive allosteric modulator (Type II) of alpha7 nACh receptors, functional human α7 nicotinic acetylcholine receptor (nAChR) generated from Escherichia coli that opens a new avenue for producing mammalian Cys-loop receptors to facilitate structure-based rational drug design.
Biological Activity
TQS is a type-II positive allosteric modulator of α7 nAChR. TQS potentiates agonist-invoked responses, and dramatically reduces the rate of desensitization of α7 nAChR. The compound has no agonist activity alone. The EC50 for potentiation of submaximal doses of acetylcholine is 6.2μM.
in vivo
TQS (1 or 4 mg/kg; i.p.) reduces the expression of LPS-induced IκB mRNA, CD11b mRNA and regulates microglial morphological changes in the hippocampus[1].
| Animal Model: | Male C57BL/6J mice[1] |
| Dosage: | 1 or 4 mg/kg |
| Administration: | I.p. |
| Result: | Reduced the expression of LPS-induced IκB mRNA, CD11b mRNA and regulated microglial morphological changes in the hippocampus. |
TQS Preparation Products And Raw materials
Raw materials
Preparation Products
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