HMB-Val-Ser-Leu-VE
- Product Name
- HMB-Val-Ser-Leu-VE
- CAS No.
- 862891-04-1
- Chemical Name
- HMB-Val-Ser-Leu-VE
- Synonyms
- HMB-Val-Ser-Leu-VE;YQKMRGLFGXKLJC-VOSPOJDESA-N;N-(3-Hydroxy-2-methylbenzoyl)-L-valyl-N-[(1S,2E)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-butenyl]-L-serinamide;L-Serinamide, N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(1S,2E)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-buten-1-yl]-
- CBNumber
- CB42591274
- Molecular Formula
- C26H39N3O7
- Formula Weight
- 505.6
- MOL File
- 862891-04-1.mol
HMB-Val-Ser-Leu-VE Property
- Boiling point:
- 754.1±60.0 °C(Predicted)
- Density
- 1.166±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 9.57±0.10(Predicted)
- Sequence
- {HMB}-Val-Ser-Leu-{VE}
N-Bromosuccinimide Price
- Product number
- 10007713
- Product name
- HMB-Val-Ser-Leu-VE
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $71
- Updated
- 2024/03/01
- Product number
- 10007713
- Product name
- HMB-Val-Ser-Leu-VE
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $313
- Updated
- 2024/03/01
- Product number
- 10007713
- Product name
- HMB-Val-Ser-Leu-VE
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $554
- Updated
- 2024/03/01
- Product number
- 10007713
- Product name
- HMB-Val-Ser-Leu-VE
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $1210
- Updated
- 2024/03/01
- Product number
- C4090
- Product name
- HMB-Val-Ser-Leu-VE
- Packaging
- 1mg
- Price
- $79
- Updated
- 2021/12/16
HMB-Val-Ser-Leu-VE Chemical Properties,Usage,Production
Uses
HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC50 of 0.033 μM[1].
Definition
ChEBI: N-(3-hydroxy-2-methylbenzoyl)-l-valyl-n-[(1s,2e)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-butenyl]-l-serinamide is a dipeptide.
Biological Activity
hmb-val-ser-leu-ve is an irreversible, cell-permeable, potent and specific inhibitor of the trypsin-like activity of the 20s proteasome with ic50 value of 33 nm [1].the 20s proteasome is a 700 kda, cylinder-shaped protease with multiple catalytic centers within the ubiquitin-proteasome pathway and plays an important role in the selective degradation of intracellular proteins. proteasomes remove abnormal proteins and play an important role in cell-cycle progression and apoptosis [1][2].hmb-val-ser-leu-ve is a tripeptide-based compound bearing a c-terminal vinyl ester that acts as a potent and selective inhibitor of the trypsin-like activity of the 20s proteasome with ic50 value of 33 nm [1]. in two colon-carcinoma cell lines (coo115, hct116), hmb-val-ser-leu-ve was nontoxic and did not affect cell proliferation. in hla-a2 positive lymphoblastoid cells, hmb-val-ser-leu-ve caused a dose-dependent increase of clg-specific killing, suggesting that hmb-val-ser-leu-ve favored the generation and presentation of immunogenic peptides presented by mhc class i molecules [1].
References
[1]. marastoni m, baldisserotto a, cellini s, et al. peptidyl vinyl ester derivatives: new class of selective inhibitors of proteasome trypsin-like activity. j med chem. 2005 jul 28;48(15):5038-42.
[2]. demartino gn, slaughter ca. the proteasome, a novel protease regulated by multiple mechanisms.
HMB-Val-Ser-Leu-VE Preparation Products And Raw materials
Raw materials
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