Pamoic acid

Product Name: Pamoic acid
CAS No.: 130-85-8
Chemical Name: Pamoic acid
Synonyms: EMBONIC ACID;Pamoic;PaMoic aci;Pamic acid;PAMOIC ACID;PalMer acid;Pamuric acid;EMBIONIC ACID;PamoicAcid98%;PamoicAcid>
CBNumber: CB4262523
Molecular Formula: C23H16O6
Formula Weight: 388.37
MOL File: 130-85-8.mol

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Pamoic acid Property

Melting point:: ≥300 °C (dec.)
Boiling point:: 434.1°C (rough estimate)
Density: 1.2472 (rough estimate)
refractive index: 1.4593 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in nitrobenzene, pyridine
form: Crystalline Powder
pka: 2.67±0.30(Predicted)
color: Yellow to yellow-green
Water Solubility: PRACTICALLY INSOLUBLE
Merck: 14,7005
BRN: 901319
InChIKey: WLJNZVDCPSBLRP-UHFFFAOYSA-N
CAS DataBase Reference: 130-85-8(CAS DataBase Reference)
EPA Substance Registry System: 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy- (130-85-8)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-48-41-37/38-20/21/22
Safety Statements: 26-36-45-36/37/39-22
WGK Germany: 3
RTECS: QL2180000
TSCA: Yes
HS Code: 29182990
Toxicity: eye-rbt 100 mg MOD FCTOD7 20,573,82

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 45150
Product name: Pamoic acid
Purity: ≥97.0% (T)
Packaging: 100g
Price: $133
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1493000
Product name: Pamoic acid
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 250mg
Price: $410
Updated: 2025/07/31

TCI Chemical

Product number: P0761
Product name: Pamoic Acid
Purity: >95.0%(T)
Packaging: 25g
Price: $24
Updated: 2025/07/31

Cayman Chemical

Product number: 13946
Product name: Pamoic Acid
Purity: ≥98%
Packaging: 50g
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 13946
Product name: Pamoic Acid
Purity: ≥98%
Packaging: 100g
Price: $89
Updated: 2024/03/01

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Pamoic acid Chemical Properties,Usage,Production

Chemical Properties

Pamoic acid is yellow to yellow-green crystalline powder

Uses

Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time fluorescence enzymatic characterization study of specialized human DNA polymerases.

Uses

Pamoic acid is used in preparation of repository derivatives of medicinal agents, used in pharmacology to increase the solubility of a drug in water.

Definition

ChEBI: Pamoic acid is a dicarboxylic acid. It is functionally related to a 2-naphthoic acid. It is a conjugate acid of a pamoate(2-).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biological Activity

(1)Pamoic acid can inhibit Cas9 endonuclease activity. It effectively blocks bacterial or mammalian genome editing mediated by SpyCas9, SauCas9 or BE4 base editors at multiple endogenous gene loci. In addition, pamoic acid displays substrate competitive and PAM binding site occupancy mechanisms that selectively inhibit linear DNA cleavage compared to Cas9 cleavage of superhelical DNA. Importantly, pamoic acid pharmacologically modulates Cas9-mediated genome editing in mice.
(2)GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes.

Safety Profile

Poison by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Pamoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Ciprofloxacin hydrochloride

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Pamoic acid Suppliers

Americas 1 Belgium 4 Canada 3 China 284 Europe 3 France 1 Germany 6 India 34 Japan 4 Slovakia 1 South Korea 1 Switzerland 3 Turkey 1 United Kingdom 13 United States 45 Global 404

Toronto Research Chemicals

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Email: info@trc-canada.com
Country: Canada
ProdList: 6038
Advantage: 71

Toronto Research Chemicals Inc.

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Fax: --
Email: info@trc-canada.com
Country: Canada
ProdList: 6668
Advantage: 58

A Unisource India

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Country: Canada
ProdList: 619
Advantage: 58

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View Lastest Price from Pamoic acid manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: Pamoic acid 130-85-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-21

Taizhou Creating Bio-pharm co., ltd.

Product: Pamoic acid 130-85-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 10T
Release date: 2024-05-28

Henan Aochuang Chemical Co.,Ltd.

Product: Pamoic acid 130-85-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

130-85-8, Pamoic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Pyrantel pamoate Bufexamac CHLOROPHOSPHONAZO III Folic acid Stearic acid 3-Hydroxybenzoic acid Hyaluronic acid 2,3,4-Trihydroxybenzoic acid Methylparaben 2'-Hydroxy-3-phenylpropiophenone Benzohydroxamic acid Salicylic acid Butylparaben Nalidixic acid 1-Hydroxy-2-naphthoic acid Cobalt naphthenate Citric acid

PAMOIC ACID

EMBONIC ACID

EMBIONIC ACID

Pamoic

2-Naphthalenecarboxylic acid, 4,4-methylenebis3-hydroxy-

1,1'-methylene-bis(2-hydroxy-3-naphthoic acid)

PAMOIC ACID pure

1,1μ-Methylene-bis(2-hydroxy-3-naphthoic acid), 4,4μ-Methylenebis(3-hydroxy-2-naphthoic acid), Embonic acid

Bis(2-hydroxy-3-carboxy-1-naphthyl)methane

Pamoic Acid (250 mg)

PamoicAcid98%

4,4'-Methylenebis[3-hydroxy-

PaMoic aci

PaMoic acid >=97.0% (T)

PalMer acid

4-[(3-carboxylato-2-hydroxy-1-naphthalenyl)methyl]-3-hydroxy-2-naphthalenecarboxylate

3,3-dihydroxy-4,4-methylenedi(2-naphthoic acid)

Embonic acid~4,4-Methylenebis(3-hydroxy-2-naphthoic acid)

PAMOIC ACID FREE ACID

Pamic acid

2,2'-DIHYDROXY-1,1'-DINAPHTHYLMETHANE 3,3'-DICARBOXYLIC ACID

4-[(3-CARBOXY-2-HYDROXY-NAPHTHALEN-1-YL)METHYL]-3-HYDROXY-NAPHTHALENE-2-CARBOXYLIC ACID

4,4'-METHYLENE BIS-(3-HYDROXY-2-NAPTHOIC ACID)

4-4'-METHYLENE-BIS-[2-HYDROXY-3-NAPHTHOIC ACID]

4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHALENECARBOXYLIC ACID)

4,4-METHYLENEBIS[3-HYDROXY-2-NAPHTHALENECARBOXYLIC ACID]

4,4-METHYLENEBIS(3-HYDROXY-2-NAPHTHOIC ACID)

4,4’-methylenebis(3-hydroxy-2-naphthalenecarboxylicaci

4,4’-methylenebis(3-hydroxy-2-naphthoicaci

4,4’-methylenebis[3-hydroxy-2-naphthalenecarboxylicaci

PamoicAcid&gt

Pamoic acid, 99%,

Pamoic Acid (1493000)

Embonic acid, Pamoic acid

4-[(3-carboxy-2-hydroxy-1-naphthyl)methyl]-3-hydroxy-naphthalene-2-carboxylic acid

4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)

2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-

3,3'-dihydroxy-4,4'-methylenedi(2-naphthoic acid)

Pamuric acid

130-85-8

C23H16O6

Organic Building Blocks

C13 to C42+

Carboxylic Acids

Carbonyl Compounds

Building Blocks

Antiparasitic Agents

Bioactive Small Molecules

Biochemicals and Reagents

Building Blocks

C13 to C42+

Carbonyl Compounds

Carboxylic Acids

Cell Biology

Chemical Synthesis

Fatty Acids and conjugates

Fatty Acyls

Lipids