ChemicalBook > CAS DataBase List > Pamoic acid

Pamoic acid

Product Name
Pamoic acid
CAS No.
130-85-8
Chemical Name
Pamoic acid
Synonyms
EMBONIC ACID;Pamoic;PaMoic aci;Pamic acid;PAMOIC ACID;PalMer acid;Pamuric acid;EMBIONIC ACID;PamoicAcid98%;PamoicAcid>
CBNumber
CB4262523
Molecular Formula
C23H16O6
Formula Weight
388.37
MOL File
130-85-8.mol
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Pamoic acid Property

Melting point:
≥300 °C (dec.)
Boiling point:
434.1°C (rough estimate)
Density 
1.2472 (rough estimate)
refractive index 
1.4593 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in nitrobenzene, pyridine
form 
Crystalline Powder
pka
2.67±0.30(Predicted)
color 
Yellow to yellow-green
Water Solubility 
PRACTICALLY INSOLUBLE
Merck 
14,7005
BRN 
901319
InChIKey
WLJNZVDCPSBLRP-UHFFFAOYSA-N
CAS DataBase Reference
130-85-8(CAS DataBase Reference)
EPA Substance Registry System
2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy- (130-85-8)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-48-41-37/38-20/21/22
Safety Statements 
26-36-45-36/37/39-22
WGK Germany 
3
RTECS 
QL2180000
TSCA 
Yes
HS Code 
29182990
Toxicity
eye-rbt 100 mg MOD FCTOD7 20,573,82
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
45150
Product name
Pamoic acid
Purity
≥97.0% (T)
Packaging
100g
Price
$133
Updated
2025/07/31
Sigma-Aldrich
Product number
1493000
Product name
Pamoic acid
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
250mg
Price
$410
Updated
2025/07/31
TCI Chemical
Product number
P0761
Product name
Pamoic Acid
Purity
>95.0%(T)
Packaging
25g
Price
$24
Updated
2025/07/31
Cayman Chemical
Product number
13946
Product name
Pamoic Acid
Purity
≥98%
Packaging
50g
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
13946
Product name
Pamoic Acid
Purity
≥98%
Packaging
100g
Price
$89
Updated
2024/03/01
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Pamoic acid Chemical Properties,Usage,Production

Chemical Properties

Pamoic acid is yellow to yellow-green crystalline powder

Uses

Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time fluorescence enzymatic characterization study of specialized human DNA polymerases.

Uses

Pamoic acid is used in preparation of repository derivatives of medicinal agents, used in pharmacology to increase the solubility of a drug in water.

Definition

ChEBI: Pamoic acid is a dicarboxylic acid. It is functionally related to a 2-naphthoic acid. It is a conjugate acid of a pamoate(2-).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biological Activity

(1)Pamoic acid can inhibit Cas9 endonuclease activity. It effectively blocks bacterial or mammalian genome editing mediated by SpyCas9, SauCas9 or BE4 base editors at multiple endogenous gene loci. In addition, pamoic acid displays substrate competitive and PAM binding site occupancy mechanisms that selectively inhibit linear DNA cleavage compared to Cas9 cleavage of superhelical DNA. Importantly, pamoic acid pharmacologically modulates Cas9-mediated genome editing in mice.
(2)GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes.

Safety Profile

Poison by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Pamoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Ciprofloxacin hydrochloride
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Pamoic acid Suppliers

Americas 1 Belgium 4 Canada 3 China 284 Europe 3 France 1 Germany 6 India 34 Japan 4 Slovakia 1 South Korea 1 Switzerland 3 Turkey 1 United Kingdom 13 United States 45 Global 404
Ark Pharm, Inc.
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Alfa Chemistry
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View Lastest Price from Pamoic acid manufacturers

Shaanxi Xianhe Biotech Co., Ltd
Product
Pamoic acid 130-85-8
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000kg
Release date
2025-04-21
Taizhou Creating Bio-pharm co., ltd.
Product
Pamoic acid 130-85-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
10T
Release date
2024-05-28
Henan Aochuang Chemical Co.,Ltd.
Product
Pamoic acid 130-85-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29

130-85-8, Pamoic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Pyrantel pamoate Bufexamac CHLOROPHOSPHONAZO III Folic acid Stearic acid 3-Hydroxybenzoic acid Hyaluronic acid 2,3,4-Trihydroxybenzoic acid Methylparaben 2'-Hydroxy-3-phenylpropiophenone Benzohydroxamic acid Salicylic acid Butylparaben Nalidixic acid 1-Hydroxy-2-naphthoic acid Cobalt naphthenate Citric acid

  • PAMOIC ACID
  • EMBONIC ACID
  • EMBIONIC ACID
  • Pamoic
  • 2-Naphthalenecarboxylic acid, 4,4-methylenebis3-hydroxy-
  • 1,1'-methylene-bis(2-hydroxy-3-naphthoic acid)
  • PAMOIC ACID pure
  • 1,1μ-Methylene-bis(2-hydroxy-3-naphthoic acid), 4,4μ-Methylenebis(3-hydroxy-2-naphthoic acid), Embonic acid
  • Bis(2-hydroxy-3-carboxy-1-naphthyl)methane
  • Pamoic Acid (250 mg)
  • PamoicAcid98%
  • 4,4'-Methylenebis[3-hydroxy-
  • PaMoic aci
  • PaMoic acid >=97.0% (T)
  • PalMer acid
  • 4-[(3-carboxylato-2-hydroxy-1-naphthalenyl)methyl]-3-hydroxy-2-naphthalenecarboxylate
  • 3,3-dihydroxy-4,4-methylenedi(2-naphthoic acid)
  • Embonic acid~4,4-Methylenebis(3-hydroxy-2-naphthoic acid)
  • PAMOIC ACID FREE ACID
  • Pamic acid
  • 2,2'-DIHYDROXY-1,1'-DINAPHTHYLMETHANE 3,3'-DICARBOXYLIC ACID
  • 4-[(3-CARBOXY-2-HYDROXY-NAPHTHALEN-1-YL)METHYL]-3-HYDROXY-NAPHTHALENE-2-CARBOXYLIC ACID
  • 4,4'-METHYLENE BIS-(3-HYDROXY-2-NAPTHOIC ACID)
  • 4-4'-METHYLENE-BIS-[2-HYDROXY-3-NAPHTHOIC ACID]
  • 4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHALENECARBOXYLIC ACID)
  • 4,4-METHYLENEBIS[3-HYDROXY-2-NAPHTHALENECARBOXYLIC ACID]
  • 4,4-METHYLENEBIS(3-HYDROXY-2-NAPHTHOIC ACID)
  • 4,4’-methylenebis(3-hydroxy-2-naphthalenecarboxylicaci
  • 4,4’-methylenebis(3-hydroxy-2-naphthoicaci
  • 4,4’-methylenebis[3-hydroxy-2-naphthalenecarboxylicaci
  • PamoicAcid&gt
  • Pamoic acid, 99%,
  • Pamoic Acid (1493000)
  • Embonic acid, Pamoic acid
  • 4-[(3-carboxy-2-hydroxy-1-naphthyl)methyl]-3-hydroxy-naphthalene-2-carboxylic acid
  • 4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)
  • 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-
  • 3,3'-dihydroxy-4,4'-methylenedi(2-naphthoic acid)
  • Pamuric acid
  • 130-85-8
  • C23H16O6
  • Organic Building Blocks
  • C13 to C42+
  • Carboxylic Acids
  • Carbonyl Compounds
  • Building Blocks
  • Antiparasitic Agents
  • Bioactive Small Molecules
  • Biochemicals and Reagents
  • Building Blocks
  • C13 to C42+
  • Carbonyl Compounds
  • Carboxylic Acids
  • Cell Biology
  • Chemical Synthesis
  • Fatty Acids and conjugates
  • Fatty Acyls
  • Lipids