LAS101057

Product Name: LAS101057
CAS No.: 925676-48-8
Chemical Name: LAS101057
Synonyms: LAS101057;LAS-101057,LAS101057;LAS101057, 10 mM in DMSO;N-[5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide;Cyclopropanecarboxamide, N-[5-(3-fluoro-4-pyridinyl)-6-(3-pyridinyl)-2-pyrazinyl]-;N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide(WXFC0500)
CBNumber: CB42628024
Molecular Formula: C18H14FN5O
Formula Weight: 335.34
MOL File: 925676-48-8.mol

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LAS101057 Property

Boiling point:: 509.2±50.0 °C(Predicted)
Density: 1.400±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:125.0(Max Conc. mg/mL);372.75(Max Conc. mM)
form: A solid
pka: 11.70±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28435
Product name: LAS101057
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 28435
Product name: LAS101057
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 28435
Product name: LAS101057
Packaging: 25mg
Price: $254
Updated: 2024/03/01

Cayman Chemical

Product number: 28435
Product name: LAS101057
Packaging: 50mg
Price: $477
Updated: 2024/03/01

ChemScene

Product number: CS-6718
Product name: LAS101057
Purity: 99.78%
Packaging: 5mg
Price: $160
Updated: 2021/12/16

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LAS101057 Chemical Properties,Usage,Production

Uses

LAS 101057 is a potent, selective, and orally efficacious A2B receptor antagonist, was identified as a clinical development candidate. It inhibits agonist-induced IL-6 production in human fibroblasts and is active in an ovalbumin (OVA)-sensitized mouse model after oral administration, reducing airway hyperresponsiveness to methacholine, Th2 cytokine production and OVA-specific IgE levels.

in vivo

At 3 mg/kg, LAS101057 is active in preventing Acetyl-β-methylcholine-induced AHR, and at 10 mg/kg it inhibits AHR to Acetyl-β-methylcholine to a level virtually equal to that seen with Hexadecadrol at 1 mg/kg^[1].

LAS101057 Preparation Products And Raw materials

Raw materials

Preparation Products

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LAS101057 Suppliers

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925676-48-8, LAS101057Related Search:

LAS101057

N-[5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide

N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide(WXFC0500)

Cyclopropanecarboxamide, N-[5-(3-fluoro-4-pyridinyl)-6-(3-pyridinyl)-2-pyrazinyl]-

LAS-101057,LAS101057

LAS101057, 10 mM in DMSO

925676-48-8