ChemicalBook > CAS DataBase List > CZC-25146 hydrochloride

CZC-25146 hydrochloride

Product Name
CZC-25146 hydrochloride
CAS No.
1330003-04-7
Chemical Name
CZC-25146 hydrochloride
Synonyms
CS-1074;CS-1206;CZC-25146.HCl;CZC-25146 hydrochL;CZC-25146 hydrochloride;CZC-25146 hydrochloride >=98% (HPLC);CZC-25146; CZC 25146; CZC25146;CZC25146 HYDROCHLORIDE;CZC 25146 HYDROCHLORIDE;N-[2-[[5-Fluoro-2-[[2-Methoxy-4-(4-Morpholinyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-MethanesulfonaMide hydrochloride;CZC-25146.HCL;N-[2-[[5-FLUORO-2-[[2-METHOXY-4-(4-MORPHOLINYL)PHENYL]AMINO]-4-PYRIMIDINYL]AMINO]PHENYL]-METHANESULFONAMIDE HYDROCHLORIDE;Leucine-rich repeat kinase 2,CZC25146,neurons,LRRK2 G2019S,CZC 25146,Inhibitor,liver diseases,inflammatory,Parkinson's disease,LRRK2,inhibit,CZC-25146,CZC 25146 hydrochloride,CZC25146 hydrochloride
CBNumber
CB42630076
Molecular Formula
C22H26ClFN6O4S
Formula Weight
524.9960432
MOL File
1330003-04-7.mol
More
Less

CZC-25146 hydrochloride Property

storage temp. 
2-8°C
solubility 
DMSO: >15mg/mL (warmed)
form 
powder
color 
white to beige
More
Less

Safety

Hazard Codes 
T,Xi
Risk Statements 
25-36
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Crysdot
Product number
CD31003869
Product name
CZC-25146 hydrochloride
Purity
98+%
Packaging
5mg
Price
$79
Updated
2021/12/16
Crysdot
Product number
CD31003869
Product name
CZC-25146 hydrochloride
Purity
98+%
Packaging
50mg
Price
$603
Updated
2021/12/16
More
Less

CZC-25146 hydrochloride Chemical Properties,Usage,Production

Uses

N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons’s disease, and is ATP-competitive.

in vivo

CZC-25146 (1 mg/kg for i.v.; 5 mg/kg for p.o.; single dosage) exhibits relatively good pharmacokinetic properties and an extensive distribution throughout animal body following intravenous injection into mice[1].
CZC-25146 (250 mg/kg; p.o.; 14 days) reduces the ATZ polymer levels in over expressing human polymeric ATZ mice[3].

Animal Model:Male CD-1 mice[1]
Dosage:1 mg/kg for i.v.; 5 mg/kg for p.o.
Administration:i.v. and p.o.; single dosage
Result:Pharmacokinetic Parameters of CZC-25146 in male CD-1 mice[1].
i.v. (1 mg/kg)p.o. (5 mg/kg)
CL (L/h/kg)2.3
Vss (L/kg)5.4
t1/2 (h)1.61
tmax (h)00.25
Cmax (ng/mL)1541357
AUClast (ng/mL·h)4192878
AUCinf (ng/mL·h)4342894
F (%)133
Animal Model:Genetically modified male mice (6 weeks; over expressing human polymeric ATZ)[3]
Dosage:250 mg/kg
Administration:p.o.; 14 days
Result:Dramatically and reproducibly reduced the ATZ polymer levels with an overall reduction from 60% in the control group to 37%

CZC-25146 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CZC-25146 hydrochloride Suppliers

China 32 United States 7 Global 39
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32159
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38630
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

1330003-04-7, CZC-25146 hydrochlorideRelated Search:


  • CZC-25146 hydrochloride
  • CZC-25146.HCl
  • CZC-25146.HCL;N-[2-[[5-FLUORO-2-[[2-METHOXY-4-(4-MORPHOLINYL)PHENYL]AMINO]-4-PYRIMIDINYL]AMINO]PHENYL]-METHANESULFONAMIDE HYDROCHLORIDE
  • N-[2-[[5-Fluoro-2-[[2-Methoxy-4-(4-Morpholinyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-MethanesulfonaMide hydrochloride
  • CS-1206
  • CS-1074
  • CZC-25146; CZC 25146; CZC25146;CZC25146 HYDROCHLORIDE;CZC 25146 HYDROCHLORIDE
  • CZC-25146 hydrochL
  • CZC-25146 hydrochloride >=98% (HPLC)
  • Leucine-rich repeat kinase 2,CZC25146,neurons,LRRK2 G2019S,CZC 25146,Inhibitor,liver diseases,inflammatory,Parkinson's disease,LRRK2,inhibit,CZC-25146,CZC 25146 hydrochloride,CZC25146 hydrochloride
  • 1330003-04-7