ChemicalBook > CAS DataBase List > DANSYLCADAVERINE

DANSYLCADAVERINE

Product Name: DANSYLCADAVERINE
CAS No.: 10121-91-2
Chemical Name: DANSYLCADAVERINE
Synonyms: 5-
CBNumber: CB4266400
Molecular Formula: C17H25N3O2S
Formula Weight: 335.46
MOL File: 10121-91-2.mol

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DANSYLCADAVERINE Property

Melting point:: 137-140 °C
Boiling point:: 505.5±60.0 °C(Predicted)
Density: 1.190±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: Methanol: 10 mg/ml
form: powder
pka: 11.96±0.50(Predicted)
color: Yellow to yellowish green
Appearance: Solid Powder
λmax: 335 nm
BRN: 2951070
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.
Biological Applications: Measuring cardiac autophagic flux; treating cataract,fibrosis,Parkinson’s disease,peritoneal ovarian tumor dissemination,respiratory diseases,lung diseases,Huntington’s disease,spinobulbar atrophy,spinocerebellar ataxia,denta

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-23

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 30432
Product name: Dansylcadaverine
Purity: BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
Packaging: 100mg
Price: $52
Updated: 2025/07/31

Sigma-Aldrich

Product number: 30432
Product name: Dansylcadaverine
Purity: BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
Packaging: 1g
Price: $261
Updated: 2025/07/31

Cayman Chemical

Product number: 15571
Product name: Monodansylcadaverine
Purity: ≥95%
Packaging: 100mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 15571
Product name: Monodansylcadaverine
Purity: ≥95%
Packaging: 250mg
Price: $58
Updated: 2024/03/01

Sigma-Aldrich

Product number: D4008
Product name: Dansylcadaverine
Purity: ≥97% (TLC)
Packaging: 100mg
Price: $45.6
Updated: 2025/07/31

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DANSYLCADAVERINE Chemical Properties,Usage,Production

Description

Monodansylcadaverine (MDC) is a fluorescent marker for autophagic vacuoles. It is an autofluorescent substance incorporated into multilamellar bodies by both an ion trapping mechanism and interaction with membrane lipids, exhibiting a Stokes shift and increased relative fluorescence in hydrophobic environments. MDC selectively accumulates in PaTu 8902 subcellular fractions containing the lysosomal enzymes acid phosphatase and cathepsin D, but not those containing the rough and smooth endoplasmic reticulum markers TRAM and cytochrome P450, respectively.

Uses

Fluorescent substrate for the assay of transamidating enzymes.

Uses

Lysosomotropic fluorescent Probe

Uses

Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells.

Definition

ChEBI: Monodansylcadaverine is a sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine. It has a role as a fluorochrome, a protective agent and an EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor. It is a sulfonamide, an aminonaphthalene, a tertiary amino compound and a primary amino compound. It is functionally related to a cadaverine.

References

[1] A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation
[2] QI JIANG. Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy.[J]. Journal of Urology, 2012, 188 4: 1361-1368. DOI:10.1016/j.juro.2012.06.004
[3] H T HAIGLER. Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.[J]. The Journal of Biological Chemistry, 1980, 255 4: 1239-1241.
[4] S N MURTHY. Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase.[J]. The Journal of Biological Chemistry, 1994, 269 36: 22907-22911.
[5] A NIEMANN H P E A Takatsuki. The lysosomotropic agent monodansylcadaverine also acts as a solvent polarity probe.[J]. Journal of Histochemistry & Cytochemistry, 2000, 48 2: 251-258. DOI: 10.1177/002215540004800210
[6] A BIEDERBICK H P E H F Kern. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles.[J]. European journal of cell biology, 1995, 66 1: 3-14.

DANSYLCADAVERINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DANSYLCADAVERINE manufacturers

Career Henan Chemical Co

Product: DANSYLCADAVERINE 10121-91-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-03

10121-91-2, DANSYLCADAVERINERelated Search:

YM155 MIF Antagonist, ISO-1 Metformin hydrochloride N,N-Dimethylaniline N,N-Dimethylcyclohexylamine N,N-DIMETHYLHYDROXYLAMINE HYDROCHLORIDE N,N'-Dimethyl-1,3-propanediamine N,N-Dimethylbenzylamine N,N-Dimethylbenzamide FMOC-L-LYS(DANSYL)-OH N-EPSILON-DANSYL-L-LYSINE DIDANSYL-L-LYSINE DANSYLCADAVERINE DIDANSYLCADAVERINE DANSYLCADAVERINE DANSYL-PGGQQIV-OH BOC-LYS(DNS)-OH 1,5-DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE, DIHYDROCHLORIDE

1-Naphthalenesulfonamide, N-(5-aminopentyl)-5-(dimethylamino)-

Monodansyl cadaverine, N-(5-Aminopentyl)-5-dimethylaminonaphthalene-1-sulfonamide, N-(Dimethylaminonaphthalenesulfonyl)-1,5-pentanediamine

N-(5-Aminopentyl)-5-(dimethylamino)-1-naphthalenesulfonamide

Einecs 233-326-9

Dansylcadaverine [N-(5-AMinopentyl)-5-diMethylaMinonaphthalen-1-sulfonaMide]

N-(5-Amino-pentyl)-5-di-methyl-amino-naphtha-lene-1-sulfon-amide

N-(Dimethyl-amino-naphtha-lene-sulfonyl)-1

5-<WBR

DANSYLCADAVERINE [N-(5-AMINOPENTYL)-5-DIMETHYLAMINONAPHTHALEN-1-SULFONAMIDE];N-(5-AMINO-PENTYL)-5-DI-METHYL-AMINO-NAPHTHA-LENE-1-SULFON-AMIDE;N-(DIMETHYL-AMINO-NAPHTHA-LENE-SULFONYL)-1;5-<WBR

5-DIMETHYLAMINONAPHTHALENE-1-(N-(5-AMINOPENTYL))-SULFONAMIDE

N-(5-AMINOPENTYL)-5-DIMETHYLAMINONAPHTHALENE-1-SULFONAMIDE

MONODANSYL CADAVERINE

N-(DIMETHYLAMINONAPHTHALENESULFONYL)-1,5-PENTANEDIAMINE

DANSYLCADAVERINE

DANSYLCADAVERINE MONODANSYLCADAVERINE

N-(5-aminopentyl)-5-(dimethylamino)naphthalene-1-sulphonamide

DANSYLCADAVERINE, FOR FLUORESCENCE

MONODANSYLCADAVERINE CRYSTALLINE

Dansyl cadaverine [5-Dimethylaminonaphthalene-1-(N-(5-aminopentyl))sulfonamide]

N-(5-AMINO-PChemicalbookENTYL)-5-DI-METHYL-AMINO-NAPHTHA-LENE-1-SULFON-AMIDE

N-(DIMETHYL-AMINO-NAPHTHA-LENE-SULFONYL)-1

N-(5-Aminopentyl)-5-(dimethylamino)naphthalene-1-sulfonamide[Dansylcadaverine

vacuoles,Inhibitor,probe,Dansylcadaverine,autophagic,Autophagy,autofluorescent,substrate,inhibit

Dansylcadaverine, 10 mM in DMSO

10121-91-2

C17H25BN3O2S

C17H25N3O2S

Biochemicals and Reagents

BioChemical

Fluorescent Probes, Labels, Particles and Stains

Fluorescent Enzyme Substrates

Detection

Alphabetical

Naphthalene