ChemicalBook > CAS DataBase List > 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione

Product Name
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
CAS No.
941575-71-9
Chemical Name
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
Synonyms
BIP-135;BIP 135,BIP135;BIP-135, 10 mM in DMSO;3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione;3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(3-benzofuranyl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-
CBNumber
CB42695130
Molecular Formula
C21H13BrN2O3
Formula Weight
421.24
MOL File
941575-71-9.mol
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3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione Property

Boiling point:
643.5±55.0 °C(Predicted)
Density 
1?+-.0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: ≥15mg/mL
pka
7.44±0.60(Predicted)
form 
powder
color 
light orange to dark orange
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0265
Product name
BIP-135
Purity
≥95% (HPLC)
Packaging
5mg
Price
$118
Updated
2022/05/15
Sigma-Aldrich
Product number
SML0265
Product name
BIP-135
Purity
≥95% (HPLC)
Packaging
25mg
Price
$465
Updated
2022/05/15
TRC
Product number
B685495
Product name
3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
Packaging
5mg
Price
$70
Updated
2021/12/16
TRC
Product number
B685495
Product name
3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
Packaging
10mg
Price
$115
Updated
2021/12/16
TRC
Product number
B685495
Product name
3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
Packaging
100mg
Price
$835
Updated
2021/12/16
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3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione Chemical Properties,Usage,Production

Uses

Acts as a potent GSK-3 inhibitor which leads to therapeutic treatment of spinal muscular atrophy.

in vivo

BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)[1].
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy[1].

Animal Model:Male and female SMN2+/+, SMN2Δ7+/+, Smn+/– mice[1]
Dosage:75 mg/kg
Administration:Intraperitoneal injection; daily; from postnatal day 0 to 21
Result:Caused a modest extension in the median survival of SMA KO animals by two days.

IC 50

GSK-3α: 16 nM (IC50); GSK-3β: 21 nM (IC50)

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione Suppliers

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941575-71-9, 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dioneRelated Search:


  • 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
  • BIP-135
  • 3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • BIP 135,BIP135
  • 1H-Pyrrole-2,5-dione, 3-(3-benzofuranyl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-
  • BIP-135, 10 mM in DMSO
  • 941575-71-9
  • Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals