Ozanimod
Uses- Product Name
- Ozanimod
- CAS No.
- 1306760-87-1
- Chemical Name
- Ozanimod
- Synonyms
- (S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile;RPC1063;Ozanimod (RPC1063);Ozamud;CS-2386;Ozanimod;Ozanimod-d6;RPC1063 Ozanimod;oxanimod(RPC1063);Ozanimod USP/EP/BP
- CBNumber
- CB42716147
- Molecular Formula
- C23H24N4O3
- Formula Weight
- 404.46
- MOL File
- 1306760-87-1.mol
Ozanimod Property
- Melting point:
- 134-137°C
- Boiling point:
- 648.3±65.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.73±0.10(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 19922
- Product name
- Ozanimod
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 19922
- Product name
- Ozanimod
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 19922
- Product name
- Ozanimod
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- 19922
- Product name
- Ozanimod
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $796
- Updated
- 2024/03/01
- Product number
- O880000
- Product name
- Ozanimod
- Packaging
- 1mg
- Price
- $40
- Updated
- 2021/12/16
Ozanimod Chemical Properties,Usage,Production
Uses
Ozanimod is an agonist that binds to S1P1 and S1P5 receptors. Experiments on rodents revealed that Ozanimod is effective against autoimmune diseases.
Description
Ozanimod is a sphingosine-1-phosphate receptor 1 (S1P1) and S1P5 agonist. It induces GTPγS binding in cell membranes expressing human S1P1 or S1P5 (EC50s = 0.41 and 11 nM, respectively) but not cell membranes expressing S1P2 or S1P3 receptors (EC50s = >10,000 nM for both). Ozanimod (0.2 mg/kg) reduces the number of peripheral lymphocytes in rats. It reduces disease severity and the number of circulating lymphocytes in a mouse model of experimental autoimmune encephalomyelitis (EAE). Ozanimod (0.3 and 1 mg/kg) reduces disease severity and body weight loss in a mouse model of TNBS-induced colitis. Formulations containing ozanimod have been used in the treatment of relapsing multiple sclerosis and ulcerative colitis.
Uses
Ozanimod is an agonist that binds to S1P1 and S1P5 receptors. Experiments on rodents revealed that Ozanimod is effective against autoimmune diseases.
in vitro
ozanimod(rpc1063) was a specific agonist for s1p1 and s1p5 receptors. the ec50values were 160 ± 60 pm and 410 ± 160 pm for s1p1 receptors in the inhibition of camp generation and[35s]-gtpγs binding. the 83% emax value of ozanimod against s1p5 receptor was 11 ± 4.3 nm. rpc1063 dose-dependently decreased s1p1 receptor re-expression on the cell surface and resulted in near complete and sustained loss of cell surface receptor expression at concentrations above 10 nm in s1p1 receptor-hek293t cells after 1 h incubation [1].
in vivo
the t1/2 of ozanimod was 4.7 h and 5.1 h in mice and rats after p.o. administration, respectively. about 81–82% decrease in circulating t lymphocyte was observed after dosing administration for 6 h, with a maximal blood concentration of 45 nm and 159 nm in rats and mice respectively. oral gavage of ozanimod dose-dependently reduced the disease score of mice in both doses (0.2 or 0.6 mg/kg/day) [1].
Enzyme inhibitor
This orally available S1PR1 modulator (FW = 404.46 g/mol; CAS 1306760- 87-1; Solubility: 81 mg/mL DMSO; < 1 mg/mL H2O), also named RPC1063 and 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden- 4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile, selectively targets sphingosine 1-Phosphate (S1P) receptors, which mediate multiple processes, including lymphocyte trafficking, cardiac function, and endothelial barrier integrity. Ozanimod is specific for S1P1R (IC50 = 0.4 nM) and S1P5R, inducing S1P1R internalization and reversibly reducing the number of circulating B and CCR7+ T lymphocytes in vivo. It shows high oral bioavailability and volume of distribution, and a circulatory half-life that supports once daily dosing. Oral ozanimod reduced inflammation and disease parameters in three autoimmune disease models, commending its use in the treatment of relapsing multiple sclerosis (RMS) and inflammatory bowel disease (IBD). Indeed, the safety and efficacy of this modulator ozanimod in relapsing multiple sclerosis is indicated on the basis of a randomized, placebo-controlled, Phase 2 trial. Other SIPR1-directed immunomodulators include laquinimod, ponesimod, and siponimod.
storage
Store at -20°C
References
scott f l, clemons b, brooks j, et al. ozanimod (rpc1063) is a potent sphingosine‐1‐phosphate receptor‐1 (s1p1) and receptor‐5 (s1p5) agonist with autoimmune disease‐modifying activity[j]. british journal of pharmacology, 2016.sandborn wj, feagan bg1, et al. ozanimod induction and maintenance treatment for ulcerative colitis. n engl j med. 2016, 374(18):1754-1762.
Ozanimod Preparation Products And Raw materials
Raw materials
Preparation Products
Ozanimod Suppliers
- Tel
- 025-66096098 3165145969
- Fax
- QQ3165145969
- sales@accoronpharm.com
- Country
- China
- ProdList
- 3924
- Advantage
- 55
- Tel
- 027-63499089 18086100502
- Fax
- 027-86589137
- linwell@126.com
- Country
- China
- ProdList
- 194
- Advantage
- 50
- Tel
- 17362916295; 17362916295
- w17362916295@163.com
- Country
- China
- ProdList
- 4054
- Advantage
- 58
- Tel
- 0556-5032306 18917961636
- Fax
- +86-556-5032307
- wtx@bayeebio.com
- Country
- China
- ProdList
- 253
- Advantage
- 61
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2923
- Advantage
- 55
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6013
- Advantage
- 61
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3404
- Advantage
- 58
- Tel
- 0523-18601685-898 18652728585
- sales@allyrise.com
- Country
- China
- ProdList
- 2742
- Advantage
- 60
- Tel
- 0755-66853366 15920483169
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 17944
- Advantage
- 56
- Tel
- 15523000485
- xingcanyaoye@sina.com
- Country
- China
- ProdList
- 1788
- Advantage
- 58
- Tel
- 132-1326052-3171 13260677953
- Fax
- 86-13343428090
- 1026393158@qq.com
- Country
- China
- ProdList
- 1931
- Advantage
- 50
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- 028-86136736 19130631884
- Fax
- 028-85265615
- sales@mic-pharma.com
- Country
- China
- ProdList
- 264
- Advantage
- 56
- Tel
- 021-52996696,15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4121
- Advantage
- 55
- Tel
- 021-50158063
- Fax
- 021-6153 1846
- sales@elivpharma.com
- Country
- China
- ProdList
- 631
- Advantage
- 58
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9254
- Advantage
- 55
- Tel
- 021-58111628 15800915896
- Fax
- QQ 3285589261
- sales@twochem.com
- Country
- China
- ProdList
- 307
- Advantage
- 55
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 0371-86658258
- Fax
- 0371-60996044
- info@coreychem.com
- Country
- China
- ProdList
- 10457
- Advantage
- 58
- Tel
- 19138486554 18582380095
- Fax
- 0575-89298961
- sales@artisbio.com
- Country
- China
- ProdList
- 3066
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9604
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8018
- Advantage
- 62
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2972
- Advantage
- 58
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 8944
- Advantage
- 58
- Tel
- 010-50973185 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29797
- Advantage
- 68
- Tel
- 027-83991130 18627774460
- Fax
- 027-83991130
- 1718093273@qq.com
- Country
- China
- ProdList
- 1890
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 132020
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- 17321237488
- kevin@resuperpharmtech.com
- Country
- China
- ProdList
- 370
- Advantage
- 58
- Tel
- 0519-83246372 13585352506
- Fax
- 0519-83246372
- Country
- China
- ProdList
- 1844
- Advantage
- 58
- Tel
- info@vigorchem.cn 1801605789
- Fax
- QQ:1801605789
- Country
- China
- ProdList
- 169
- Advantage
- 58
- Tel
- 027-59402396 13419635609
- Fax
- 027-83989310
- 13419635609@163.com
- Country
- China
- ProdList
- 1910
- Advantage
- 55
- Tel
- 0550-5196001 15000891977
- Fax
- 0550-5196001
- wj520wjxby@126.com
- Country
- China
- ProdList
- 1828
- Advantage
- 55
- Tel
- 027-027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 3974
- Advantage
- 58
- Tel
- 021-58180488
- Fax
- 021-58180499
- sales@MedChemLeader.com
- Country
- China
- ProdList
- 999
- Advantage
- 58
- Tel
- 0755-28967200 13631290199
- Fax
- 0755-28967200
- wxf@sungening.com
- Country
- China
- ProdList
- 9506
- Advantage
- 60
- Tel
- +86 18721201413
- Fax
- +86 (21) 5775-8967
- sales@biopharmaleader.com
- Country
- China
- ProdList
- 1720
- Advantage
- 58
- Tel
- 028-85255396 18302801538
- Fax
- 028-85255396
- cdnovell@163.com
- Country
- China
- ProdList
- 2220
- Advantage
- 58
- Tel
- 021-16621358918; 18516310516
- Fax
- 13045646768
- zhenlipharma888@163.com
- Country
- China
- ProdList
- 1978
- Advantage
- 58
- Tel
- 571-85586718 +8613336195806
- Fax
- +86-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 29797
- Advantage
- 60
- Tel
- 027-83778895 18602735115
- Fax
- 027-51119224
- 18602735115@163.com
- Country
- China
- ProdList
- 1991
- Advantage
- 64
- Tel
- 021-60345187 13917602471
- Fax
- 021-60345187
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 9908
- Advantage
- 58
- Tel
- 010-87568995 13439954790
- Fax
- 010-87568995
- 2539095144@qq.com
- Country
- China
- ProdList
- 180
- Advantage
- 58
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- 15502154572
- Fax
- -
- yuben012@sina.com
- Country
- China
- ProdList
- 499
- Advantage
- 58
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10305
- Advantage
- 58
- Tel
- 13302022156
- Fax
- -
- 3506745780@qq.com
- Country
- China
- ProdList
- 171
- Advantage
- 58
View Lastest Price from Ozanimod manufacturers
- Product
- Ozanimod 1306760-87-1
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-06
- Product
- Ozanimod 1306760-87-1
- Price
- US $600.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%+
- Supply Ability
- 100kgs
- Release date
- 2021-05-23
- Product
- Ozanimod 1306760-87-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 0.999
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-03