2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester

Product Name: 2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester
CAS No.: 1380331-29-2
Chemical Name: 2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester
Synonyms: METHYL 2-AMINO-5-FLUOROISONICOTINATE;2-Amino-5-fluoro-isonicotinic acid methyl ester;2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester;2-Amino-5-fluoro-isonicotinic acid methyl ester4228-4229;4-Pyridinecarboxylic acid, 2-amino-5-fluoro-, methyl ester
CBNumber: CB42717720
Molecular Formula: C7H7FN2O2
Formula Weight: 170.14
MOL File: 1380331-29-2.mol

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2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester Property

Boiling point:: 302.1±42.0 °C(Predicted)
Density: 1.339±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.75±0.24(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot

Product number: CD11268422
Product name: Methyl2-amino-5-fluoroisonicotinate
Purity: 95+%
Packaging: 100mg
Price: $218
Updated: 2021/12/16

Crysdot

Product number: CD11268422
Product name: Methyl2-amino-5-fluoroisonicotinate
Purity: 95+%
Packaging: 250mg
Price: $349
Updated: 2021/12/16

Chemenu

Product number: CM249145
Product name: Methyl2-amino-5-fluoroisonicotinate
Purity: 95%
Packaging: 1g
Price: $823
Updated: 2021/12/16

Crysdot

Product number: CD11268422
Product name: Methyl2-amino-5-fluoroisonicotinate
Purity: 95+%
Packaging: 1g
Price: $871
Updated: 2021/12/16

Alichem

Product number: 1380331292
Product name: Methyl2-Amino-5-fluoroisonicotinate
Packaging: 500mg
Price: $1634.45
Updated: 2021/12/16

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2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester Chemical Properties,Usage,Production

Synthesis

1380331-28-1

1380331-29-2

c) Synthesis of methyl 2-amino-5-fluoroisonicotinate: methyl 2-((tert-butoxycarbonyl)amino)-5-fluoroisonicotinate (1.80 g, 6.66 mmol) was dissolved in ethyl ether (40 mL) and 6 N hydrochloric acid (40 mL, 240 mmol) was added. The reaction mixture was stirred at room temperature for 20 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure to give a light brown slurry. The slurry was diluted with ethyl acetate, cooled in an ice bath to 0 °C and the pH was adjusted with saturated sodium bicarbonate solution to 8. The organic layer was separated, washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give methyl 2-amino-5-fluoroisonicotinate (932 mg, 82.2% yield) as a brown waxy solid. Mass spectrum (MS): m/z = 171.0 ([M+H]+).

References

[1] Patent: US2012/142665, 2012, A1. Location in patent: Page/Page column 28
[2] Patent: WO2012/76430, 2012, A1. Location in patent: Page/Page column 78

2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester Suppliers

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1380331-29-2, 2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl esterRelated Search:

2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester

METHYL 2-AMINO-5-FLUOROISONICOTINATE

2-Amino-5-fluoro-isonicotinic acid methyl ester

2-Amino-5-fluoro-isonicotinic acid methyl ester4228-4229

4-Pyridinecarboxylic acid, 2-amino-5-fluoro-, methyl ester

1380331-29-2