2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester
- Product Name
- 2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester
- CAS No.
- 1380331-29-2
- Chemical Name
- 2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester
- Synonyms
- METHYL 2-AMINO-5-FLUOROISONICOTINATE;2-Amino-5-fluoro-isonicotinic acid methyl ester;2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester;2-Amino-5-fluoro-isonicotinic acid methyl ester4228-4229;4-Pyridinecarboxylic acid, 2-amino-5-fluoro-, methyl ester
- CBNumber
- CB42717720
- Molecular Formula
- C7H7FN2O2
- Formula Weight
- 170.14
- MOL File
- 1380331-29-2.mol
2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester Property
- Boiling point:
- 302.1±42.0 °C(Predicted)
- Density
- 1.339±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.75±0.24(Predicted)
- Appearance
- Light yellow to yellow Solid
N-Bromosuccinimide Price
- Product number
- CD11268422
- Product name
- Methyl2-amino-5-fluoroisonicotinate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- CD11268422
- Product name
- Methyl2-amino-5-fluoroisonicotinate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $349
- Updated
- 2021/12/16
- Product number
- CM249145
- Product name
- Methyl2-amino-5-fluoroisonicotinate
- Purity
- 95%
- Packaging
- 1g
- Price
- $823
- Updated
- 2021/12/16
- Product number
- CD11268422
- Product name
- Methyl2-amino-5-fluoroisonicotinate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $871
- Updated
- 2021/12/16
- Product number
- 1380331292
- Product name
- Methyl2-Amino-5-fluoroisonicotinate
- Packaging
- 500mg
- Price
- $1634.45
- Updated
- 2021/12/16
2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester Chemical Properties,Usage,Production
Synthesis
1380331-28-1
1380331-29-2
c) Synthesis of methyl 2-amino-5-fluoroisonicotinate: methyl 2-((tert-butoxycarbonyl)amino)-5-fluoroisonicotinate (1.80 g, 6.66 mmol) was dissolved in ethyl ether (40 mL) and 6 N hydrochloric acid (40 mL, 240 mmol) was added. The reaction mixture was stirred at room temperature for 20 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure to give a light brown slurry. The slurry was diluted with ethyl acetate, cooled in an ice bath to 0 °C and the pH was adjusted with saturated sodium bicarbonate solution to 8. The organic layer was separated, washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give methyl 2-amino-5-fluoroisonicotinate (932 mg, 82.2% yield) as a brown waxy solid. Mass spectrum (MS): m/z = 171.0 ([M+H]+).
References
[1] Patent: US2012/142665, 2012, A1. Location in patent: Page/Page column 28
[2] Patent: WO2012/76430, 2012, A1. Location in patent: Page/Page column 78
2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-5-fluoro-4-pyridinecarboxylic acid methyl ester Suppliers
- Tel
- 13764913901
- Fax
- -
- info@angtibio.com
- Country
- China
- ProdList
- 4986
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 19906241957
- Fax
- -
- 1557216087@qq.com
- Country
- China
- ProdList
- 1837
- Advantage
- 55
- Tel
- 029-86115547 17791676824
- Fax
- 021-51602123
- sales@cochemical.com
- Country
- China
- ProdList
- 4006
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58
- Tel
- 21-13482015261-883 13482015261
- Fax
- +86-21-37782903
- info@genriverpharm.com
- Country
- China
- ProdList
- 444
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58