DuocarMycin TM

Product Name: DuocarMycin TM
CAS No.: 157922-77-5
Chemical Name: DuocarMycin TM
Synonyms: CS-1380;DuocarMycin TM;Duocarmycin TM, 10 mM in DMSO;(1S)-1-(Chloromethyl)-2,3-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-1H-benz[e]indol-5-ol;1H-Benz[e]indol-5-ol, 1-(chloromethyl)-2,3-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, (1S)-;DNA Alkylator/Crosslinker,alkylation,Duocarmycin TM,Inhibitor,ADC Cytotoxin,BJAB cell,inhibit,Antibiotic,duplex DNA,CBI-TMI,Antitumor,ADC Payload,WSU-DLCL2 cell
CBNumber: CB42730893
Molecular Formula: C25H23ClN2O5
Formula Weight: 466.91
MOL File: 157922-77-5.mol

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DuocarMycin TM Property

Boiling point:: 711.7±60.0 °C(Predicted)
Density: 1.389±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 50 mg/mL (107.09 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 9.43±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0029985
Product name: DuocarmycinTM
Purity: 98.99%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0029985
Product name: DuocarmycinTM
Purity: 98.99%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0029985
Product name: DuocarmycinTM
Purity: 98.99%
Packaging: 25mg
Price: $1750
Updated: 2021/12/16

ChemScene

Product number: CS-0029985
Product name: DuocarmycinTM
Purity: 98.99%
Packaging: 50mg
Price: $2750
Updated: 2021/12/16

ChemScene

Product number: CS-0029985
Product name: DuocarmycinTM
Purity: 98.99%
Packaging: 100mg
Price: $3950
Updated: 2021/12/16

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DuocarMycin TM Chemical Properties,Usage,Production

Uses

Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.

IC 50

Duocarmycins

References

[1] Zhang D, et, al. Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads. Bioconjug Chem. 2018 Feb 21;29(2):267-274. DOI:10.1021/acs.bioconjchem.7b00576

DuocarMycin TM Preparation Products And Raw materials

Raw materials

Preparation Products

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DuocarMycin TM Suppliers

China 33 United States 4 Global 37

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View Lastest Price from DuocarMycin TM manufacturers

Hangzhou Huarong Pharm Co., Ltd.

Product: Duocarmycin TM 157922-77-5
Price: US $0.00-0.00/g
Min. Order: 5mg
Purity: 99%
Supply Ability: 100KG
Release date: 2021-09-15

157922-77-5, DuocarMycin TMRelated Search:

DuocarMycin TM

CS-1380

1H-Benz[e]indol-5-ol, 1-(chloromethyl)-2,3-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, (1S)-

DNA Alkylator/Crosslinker,alkylation,Duocarmycin TM,Inhibitor,ADC Cytotoxin,BJAB cell,inhibit,Antibiotic,duplex DNA,CBI-TMI,Antitumor,ADC Payload,WSU-DLCL2 cell

Duocarmycin TM, 10 mM in DMSO

(1S)-1-(Chloromethyl)-2,3-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-1H-benz[e]indol-5-ol

157922-77-5