LCH-7749944

Product Name: LCH-7749944
CAS No.: 796888-12-5
Chemical Name: LCH-7749944
Synonyms: GNF-PF-2356;LCH-7749944;LCH-7749944 ，S1976;LCH-7749944， GNF-PF-2356;LCH-7749944, 10 mM in DMSO;N2-(3-Methoxyphenyl)-N4-((tetrahydrofuran-2-yl)methyl)quinazoline-2,4-diamine;2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]-;proliferation,cells,Inhibitor,c-Src,EGFR,inhibit,gastric,Apoptosis,LCH-7749944,PAK,cancer,PAK4,human,LCH7749944,p21 activated kinases,cyclin,LCH 7749944
CBNumber: CB42731092
Molecular Formula: C20H22N4O2
Formula Weight: 350.41
MOL File: 796888-12-5.mol

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LCH-7749944 Property

Boiling point:: 580.0±58.0 °C(Predicted)
Density: 1.272±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO: 250 mg/mL (713.45 mM)
pka: 7.68±0.30(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0088726
Product name: LCH-7749944
Purity: 99.43%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0088726
Product name: LCH-7749944
Purity: 99.43%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0088726
Product name: LCH-7749944
Purity: 99.43%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0088726
Product name: LCH-7749944
Purity: 99.43%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

CSNpharm

Product number: CSN25301
Product name: LCH7749944
Packaging: 5mg
Price: $80
Updated: 2021/12/16

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LCH-7749944 Chemical Properties,Usage,Production

Uses

LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1].

IC 50

PAK4: 14.93 μM (IC₅₀)

References

[1] Zhang J, et al. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. 2012 Apr 1;317(1):24-32. DOI:10.1016/j.canlet.2011.11.007

LCH-7749944 Preparation Products And Raw materials

Raw materials

Preparation Products

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LCH-7749944 Suppliers

China 32 United States 5 Global 37

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796888-12-5, LCH-7749944Related Search:

LCH-7749944

GNF-PF-2356

LCH-7749944， GNF-PF-2356

2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]-

N2-(3-Methoxyphenyl)-N4-((tetrahydrofuran-2-yl)methyl)quinazoline-2,4-diamine

proliferation,cells,Inhibitor,c-Src,EGFR,inhibit,gastric,Apoptosis,LCH-7749944,PAK,cancer,PAK4,human,LCH7749944,p21 activated kinases,cyclin,LCH 7749944

LCH-7749944, 10 mM in DMSO

LCH-7749944 ，S1976

796888-12-5