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CID24856225

Product Name
CID24856225
CAS No.
1073529-41-5
Chemical Name
CID24856225
Synonyms
ABL127;ML174);CID24856225;ABL127 (AB L127;ABL127 >=98% (HPLC);(3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate;4-OXO-3,3-DIPHENYL-[1,2]DIAZETIDINE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER(WX619174);(3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester;1,2-Diazetidine-1,2-dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-, 1,2-dimethyl ester, (3R)-
CBNumber
CB42750576
Molecular Formula
C17H20N2O5
Formula Weight
332.35
MOL File
1073529-41-5.mol
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CID24856225 Property

Boiling point:
422.8±48.0 °C(Predicted)
Density 
1.330±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥5mg/mL
pka
-3.45±0.40(Predicted)
form 
film
color 
colorless
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0294
Product name
ABL127
Purity
≥98% (HPLC)
Packaging
5mg
Price
$151.05
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0294
Product name
ABL127
Purity
≥98% (HPLC)
Packaging
25mg
Price
$324.5
Updated
2025/07/31
Cayman Chemical
Product number
10833
Product name
ABL 127
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
10833
Product name
ABL 127
Packaging
5mg
Price
$134
Updated
2024/03/01
Cayman Chemical
Product number
10833
Product name
ABL 127
Packaging
10mg
Price
$249
Updated
2024/03/01
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CID24856225 Chemical Properties,Usage,Production

Uses

ABL127, is a selective and covalent inhibitor of protein methylesterase 1 (PME-1).

Biological Activity

ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration.

in vivo

No significant decrease in tumor burden can be assessed in these pilot studies[1]. Gel-based profiles indicate that brain PME-1 is inactivated by ABL127, but overlapping serine hydrolase activities preclude a confident assessment of the extent of inactivation[2].

CID24856225 Preparation Products And Raw materials

Raw materials

Preparation Products

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CID24856225 Suppliers

China 24 United States 6 Global 30
Sigma-Aldrich
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Cayman Chemical Company
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Merck KGaA
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1073529-41-5, CID24856225Related Search:


  • (3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester
  • (3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate
  • ABL127
  • CID24856225
  • 4-OXO-3,3-DIPHENYL-[1,2]DIAZETIDINE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER(WX619174)
  • ABL127 (AB L127
  • ML174)
  • 1,2-Diazetidine-1,2-dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-, 1,2-dimethyl ester, (3R)-
  • ABL127 >=98% (HPLC)
  • 1073529-41-5