CID24856225
- Product Name
- CID24856225
- CAS No.
- 1073529-41-5
- Chemical Name
- CID24856225
- Synonyms
- ABL127;ML174);CID24856225;ABL127 (AB L127;ABL127 >=98% (HPLC);(3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate;4-OXO-3,3-DIPHENYL-[1,2]DIAZETIDINE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER(WX619174);(3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester;1,2-Diazetidine-1,2-dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-, 1,2-dimethyl ester, (3R)-
- CBNumber
- CB42750576
- Molecular Formula
- C17H20N2O5
- Formula Weight
- 332.35
- MOL File
- 1073529-41-5.mol
CID24856225 Property
- Boiling point:
- 422.8±48.0 °C(Predicted)
- Density
- 1.330±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥5mg/mL
- pka
- -3.45±0.40(Predicted)
- form
- film
- color
- colorless
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0294
- Product name
- ABL127
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $151.05
- Updated
- 2025/07/31
- Product number
- SML0294
- Product name
- ABL127
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $324.5
- Updated
- 2025/07/31
- Product number
- 10833
- Product name
- ABL 127
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 10833
- Product name
- ABL 127
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- 10833
- Product name
- ABL 127
- Packaging
- 10mg
- Price
- $249
- Updated
- 2024/03/01
CID24856225 Chemical Properties,Usage,Production
Uses
ABL127, is a selective and covalent inhibitor of protein methylesterase 1 (PME-1).
Biological Activity
ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration.
in vivo
No significant decrease in tumor burden can be assessed in these pilot studies[1]. Gel-based profiles indicate that brain PME-1 is inactivated by ABL127, but overlapping serine hydrolase activities preclude a confident assessment of the extent of inactivation[2].
CID24856225 Preparation Products And Raw materials
Raw materials
Preparation Products
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