(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE

Product Name: (N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE
CAS No.: 90719-30-5
Chemical Name: (N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE
Synonyms: UIC-1005;Locostatin - UIC 1005;Locostatin >=98% (HPLC);(R)-4-BENZYL-3-CROTONYL-2-OXAZOLIDINONE;(N-CROTONYL)-(4S)-BENZYL-2-OXAZOLIDINONE;(N-Crotonyl)-(R)-4-benzyl-2-oxazolidinone;4-but-2-enyl-3-propan-2-yl-2-oxazolidinone;(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE;(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDINONE;(4S)-N-Crotonyl-4-benzyl-2-oxazolidinone,99%
CBNumber: CB4284497
Molecular Formula: C14H15NO3
Formula Weight: 245.27
MOL File: 90719-30-5.mol

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(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE Property

Melting point:: 84-88 °C(lit.)
Boiling point:: 351.0±25.0 °C(Predicted)
Density: 1.205±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥30mg/mL
pka: -1?+-.0.40(Predicted)
form: powder
color: white to off-white

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L5670
Product name: Locostatin
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $67.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: L5670
Product name: Locostatin
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $262
Updated: 2025/07/31

Axon Medchem

Product number: Axon2590
Product name: Locostatin-UIC1005
Purity: 100%
Packaging: 10mg
Price: $60.5
Updated: 2021/12/16

aablocks

Product number: AA006AZ1
Product name: (S,E)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one
Purity: 100%
Packaging: 50mg
Price: $332
Updated: 2021/12/16

Ambeed

Product number: A127375
Product name: (S,E)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one
Purity: 98%
Packaging: 250mg
Price: $375
Updated: 2021/12/16

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(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE Chemical Properties,Usage,Production

Uses

Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin can be used to synthesize chemical probes toward PEBP-proteins. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].

Biochem/physiol Actions

Locostatin is a cell permeable, potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.

in vivo

Locostatin (0.5 mg/kg; i.p.; once a day for 7 days) aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice^[3].

Animal Model:	6 weeks, 18-22 g, male ICR mice (TAA model; injected intraperitoneally with 300 mg/kg TAA once a day for 2 days)^[3]
Dosage:	0.5 mg/kg
Administration:	I.p.; once a day for 7 days
Result:	Decreased the expression of RKIP, led to more severe damage, such as steatosis and hepatic lesions, increased the production of ROS in the liver and TNF-α, IL-6 and IL-1β in the sera of mice with acute liver injury, inhibitd Nrf2 and HO-1 expression in the livers of mice, induced NF-κB activation in the livers of mice,increased the phosphorylation of JNK, p38 and ERK in liver tissues.

References

[1] Beshir AB, et al. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. For Immunopathol Dis Therap. 2011;2(1):47-58. DOI:10.1615/forumimmundisther.v2.i1.60
[2] Mc Henry KT, et al. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem. 2002 Nov 4;3(11):1105-11. DOI:10.1002/1439-7633(20021104)3:11<1105::AID-CBIC1105>3.0.CO;2-S
[3] Lin X, et al. Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice. Exp Ther Med. 2018 Oct;16(4):2992-2998. DOI:10.3892/etm.2018.6542

(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE Suppliers

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90719-30-5, (N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONERelated Search:

Crotonic acid (R)-4-Benzyl-2-oxazolidinone (N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE N-CROTONYL-(4R)-ISOPROPYL 2-OXAZOLIDINONE (N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE 3-[(E)-2-BUTENOYL]-1,3-OXAZOLIDIN-2-ONE N-(ISOBUTOXYMETHYL)ACRYLAMIDE (N-ACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE 3-ACRYLOYL-2-OXAZOLIDINONE Phenprobamate (S)-4-Benzyl-2-oxazolidinone

(4S)-3-[(E)-BUT-2-ENOYL]-4-BENZYL-2-OXAZOLIDINONE

(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDINONE

(N-CROTONYL)-(4S)-BENZYL-2-OXAZOLIDINONE

(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE

UIC-1005

(R)-4-BENZYL-3-CROTONYL-2-OXAZOLIDINONE

(4S)-N-Crotonyl-4-benzyl-2-oxazolidinone, 99%

(N-Crotonyl)-(R)-4-benzyl-2-oxazolidinone

(4S)-N-Crotonyl-4-benzyl-2-oxazolidinone,99%

(4S)-3-[(E)-1-Oxo-2-butenyl]-4-(phenylmethyl)-2-oxazolidinone

(4S)-4-benzyl-3-[(E)-but-2-enoyl]-1,3-oxazolidin-2-one

Locostatin - UIC 1005

4-but-2-enyl-3-propan-2-yl-2-oxazolidinone

2-Oxazolidinone, 3-[(2E)-1-oxo-2-buten-1-yl]-4-(phenylmethyl)-, (4S)-

Locostatin >=98% (HPLC)

(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE USP/EP/BP

(S,E)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one

90719-30-5

Peptide