4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol

Product Name: 4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol
CAS No.: 500565-15-1
Chemical Name: 4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol
Synonyms: HM03;HM03 (NSC130813);HM03, 10 mM in DMSO;Phenol, 4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-;shock,HM 03,inhibit,heat,tumor,cancer,cell,HM03,protein,Heat shock proteins,HSP,Inhibitor,HCT116,HM-03
CBNumber: CB43042135
Molecular Formula: C26H27ClN4O2
Formula Weight: 462.97
MOL File: 500565-15-1.mol

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4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol Property

Boiling point:: 603.7±55.0 °C(Predicted)
Density: 1.327±0.06 g/cm3(Predicted)
solubility: DMSO: Soluble: =10 mg/ml
Ethanol: Soluble: =10 mg/ml
form: Solid
pka: 10.20±0.50(Predicted)
color: Pink to red

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0103679
Product name: HM03
Purity: 98.06%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0103679
Product name: HM03
Purity: 98.06%
Packaging: 10mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0103679
Product name: HM03
Purity: 98.06%
Packaging: 50mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0103679
Product name: HM03
Purity: 98.06%
Packaging: 100mg
Price: $600
Updated: 2021/12/16

DC Chemicals

Product number: 020456
Product name: HM03
Packaging: 003
Price: $1700
Updated: 2021/12/16

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4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol Chemical Properties,Usage,Production

Uses

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1].

IC 50

HSPA5

References

[1] Huang M, et al. Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors. Bioorg Med Chem Lett. 2013;23(10):3044‐3050. DOI:10.1016/j.bmcl.2013.03.035
[2] AHMEDH. ELMENOUFY. Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1–XPF[J]. Journal of Medicinal Chemistry, 2019, 62 17: 7684-7696. DOI: 10.1021/acs.jmedchem.9b00326
[3] ANDREJA KOVAČ. Discovery of New Inhibitors of d-Alanine:d-Alanine Ligase by Structure-Based Virtual Screening†[J]. Journal of Medicinal Chemistry, 2008, 51 23: 7442-7448. DOI: 10.1021/jm800726b
[4] LARS PETTER JORDHEIM. Small molecule inhibitors of ERCC1-XPF protein-protein interaction synergize alkylating agents in cancer cells.[J]. Molecular Pharmacology, 2013, 84 1: 12-24. DOI: 10.1124/mol.112.082347

4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol Suppliers

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500565-15-1, 4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenolRelated Search:

HM03

Phenol, 4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-

shock,HM 03,inhibit,heat,tumor,cancer,cell,HM03,protein,Heat shock proteins,HSP,Inhibitor,HCT116,HM-03

HM03 (NSC130813)

HM03, 10 mM in DMSO

500565-15-1