4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol
- Product Name
- 4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol
- CAS No.
- 500565-15-1
- Chemical Name
- 4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol
- Synonyms
- HM03;HM03 (NSC130813);HM03, 10 mM in DMSO;Phenol, 4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-;shock,HM 03,inhibit,heat,tumor,cancer,cell,HM03,protein,Heat shock proteins,HSP,Inhibitor,HCT116,HM-03
- CBNumber
- CB43042135
- Molecular Formula
- C26H27ClN4O2
- Formula Weight
- 462.97
- MOL File
- 500565-15-1.mol
4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol Property
- Boiling point:
- 603.7±55.0 °C(Predicted)
- Density
- 1.327±0.06 g/cm3(Predicted)
- solubility
- DMSO: Soluble: =10 mg/ml
Ethanol: Soluble: =10 mg/ml - form
- Solid
- pka
- 10.20±0.50(Predicted)
- color
- Pink to red
N-Bromosuccinimide Price
- Product number
- CS-0103679
- Product name
- HM03
- Purity
- 98.06%
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0103679
- Product name
- HM03
- Purity
- 98.06%
- Packaging
- 10mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0103679
- Product name
- HM03
- Purity
- 98.06%
- Packaging
- 50mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0103679
- Product name
- HM03
- Purity
- 98.06%
- Packaging
- 100mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- 020456
- Product name
- HM03
- Packaging
- 001
- Price
- $450
- Updated
- 2021/12/16
4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol Chemical Properties,Usage,Production
Uses
HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1].
IC 50
HSPA5
References
[1] Huang M, et al. Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors. Bioorg Med Chem Lett. 2013;23(10):3044‐3050. DOI:10.1016/j.bmcl.2013.03.035
[2] AHMEDH. ELMENOUFY. Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1–XPF[J]. Journal of Medicinal Chemistry, 2019, 62 17: 7684-7696. DOI: 10.1021/acs.jmedchem.9b00326
[3] ANDREJA KOVAČ. Discovery of New Inhibitors of d-Alanine:d-Alanine Ligase by Structure-Based Virtual Screening†[J]. Journal of Medicinal Chemistry, 2008, 51 23: 7442-7448. DOI: 10.1021/jm800726b
[4] LARS PETTER JORDHEIM. Small molecule inhibitors of ERCC1-XPF protein-protein interaction synergize alkylating agents in cancer cells.[J]. Molecular Pharmacology, 2013, 84 1: 12-24. DOI: 10.1124/mol.112.082347
4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol Preparation Products And Raw materials
Raw materials
Preparation Products
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