4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester

Product Name: 4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester
CAS No.: 85909-04-2
Chemical Name: 4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester
Synonyms: Methyl 4-(Boc-amino)butanoate;METHYL 4-(TERT-BUTOXYCARBONYLAMINO) BUTANOATE;methyl 4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate;4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester;Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester
CBNumber: CB43053544
Molecular Formula: C10H19NO4
Formula Weight: 217.26
MOL File: 85909-04-2.mol

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4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Property

storage temp.: 2-8°C
Appearance: White to light yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M224558
Product name: Methyl4-(tert-Butoxycarbonylamino)butanoate
Packaging: 25mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M224558
Product name: Methyl4-(tert-Butoxycarbonylamino)butanoate
Packaging: 250mg
Price: $265
Updated: 2021/12/16

AK Scientific

Product number: 3954CU
Product name: Methyl4-((tert-butoxycarbonyl)amino)butanoate
Packaging: 5g
Price: $254
Updated: 2021/12/16

AK Scientific

Product number: 3954CU
Product name: Methyl4-((tert-butoxycarbonyl)amino)butanoate
Packaging: 250mg
Price: $85
Updated: 2021/12/16

Ambeed

Product number: A194669
Product name: Methyl4-((tert-butoxycarbonyl)amino)butanoate
Purity: 95%
Packaging: 5g
Price: $144
Updated: 2021/12/16

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4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Chemical Properties,Usage,Production

Synthesis

57294-38-9

74-88-4

85909-04-2

General Steps: Step 1: Synthesis of 4-(tert-butoxycarbonylamino)butyric acid: 4-aminobutyric acid (25 g, 242 mmol) was dissolved in H2O (500 mL) at room temperature, Na2CO3 (75 g, 726 mmol) was added, followed by dropwise addition of a THF (200 mL) solution of Boc2O (95 g, 435 mmol). The reaction mixture was stirred at room temperature for 12 h and then concentrated under reduced pressure. The aqueous phase was extracted with Et2O, followed by adjusting the pH to 4-5 with citric acid and extracting with EtOAc. The organic layers were combined, dried over Na2SO4 and concentrated to give 4-(tert-butoxycarbonylamino)butyric acid (45 g, 90%) as a colorless oil.ESI-MS (EI+, m/z): 226 [M + Na]+. Step 2: Synthesis of methyl 4-(tert-butoxycarbonylamino)butyrate: 4-(tert-butoxycarbonylamino)butyric acid (7.0 g, 34.5 mmol) and K2CO3 (9.5 g, 68.9 mmol) were dissolved in acetone (70 mL) and MeI (7.5 g, 51.8 mmol) was added at room temperature. The reaction solution was stirred at 45 °C for 12 hours. Upon completion of the reaction, the mixture was washed with water and saturated NaCl solution, dried over Na2SO4 and concentrated to give methyl 4-(tert-butoxycarbonylamino)butyrate (6.2 g, 83%) as a yellow oil.ESI-MS (EI+, m/z): 240 [M + Na]+.

References

[1] Patent: WO2013/149121, 2013, A1. Location in patent: Page/Page column 75; 76
[2] Patent: US2015/111864, 2015, A1. Location in patent: Paragraph 0113; 0115
[3] Farmaco, 2004, vol. 59, # 5, p. 381 - 388
[4] Organic and Biomolecular Chemistry, 2012, vol. 10, # 4, p. 861 - 868

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Preparation Products And Raw materials

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Career Henan Chemical Co

Product: 4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester 85909-04-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-99.9%
Supply Ability: 100kg
Release date: 2020-01-10

85909-04-2, 4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl esterRelated Search:

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester

METHYL 4-(TERT-BUTOXYCARBONYLAMINO) BUTANOATE

Methyl 4-(Boc-amino)butanoate

Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester

methyl 4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate

85909-04-2

CMLLYL