4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester
- Product Name
- 4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester
- CAS No.
- 85909-04-2
- Chemical Name
- 4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester
- Synonyms
- Methyl 4-(Boc-amino)butanoate;METHYL 4-(TERT-BUTOXYCARBONYLAMINO) BUTANOATE;methyl 4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate;4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester;Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester
- CBNumber
- CB43053544
- Molecular Formula
- C10H19NO4
- Formula Weight
- 217.26
- MOL File
- 85909-04-2.mol
4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Property
- storage temp.
- 2-8°C
- Appearance
- White to light yellow Solid
N-Bromosuccinimide Price
- Product number
- M224558
- Product name
- Methyl4-(tert-Butoxycarbonylamino)butanoate
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M224558
- Product name
- Methyl4-(tert-Butoxycarbonylamino)butanoate
- Packaging
- 250mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 3954CU
- Product name
- Methyl4-((tert-butoxycarbonyl)amino)butanoate
- Packaging
- 5g
- Price
- $254
- Updated
- 2021/12/16
- Product number
- 3954CU
- Product name
- Methyl4-((tert-butoxycarbonyl)amino)butanoate
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- A194669
- Product name
- Methyl4-((tert-butoxycarbonyl)amino)butanoate
- Purity
- 95%
- Packaging
- 5g
- Price
- $144
- Updated
- 2021/12/16
4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Chemical Properties,Usage,Production
Synthesis
57294-38-9
74-88-4
85909-04-2
General Steps: Step 1: Synthesis of 4-(tert-butoxycarbonylamino)butyric acid: 4-aminobutyric acid (25 g, 242 mmol) was dissolved in H2O (500 mL) at room temperature, Na2CO3 (75 g, 726 mmol) was added, followed by dropwise addition of a THF (200 mL) solution of Boc2O (95 g, 435 mmol). The reaction mixture was stirred at room temperature for 12 h and then concentrated under reduced pressure. The aqueous phase was extracted with Et2O, followed by adjusting the pH to 4-5 with citric acid and extracting with EtOAc. The organic layers were combined, dried over Na2SO4 and concentrated to give 4-(tert-butoxycarbonylamino)butyric acid (45 g, 90%) as a colorless oil.ESI-MS (EI+, m/z): 226 [M + Na]+. Step 2: Synthesis of methyl 4-(tert-butoxycarbonylamino)butyrate: 4-(tert-butoxycarbonylamino)butyric acid (7.0 g, 34.5 mmol) and K2CO3 (9.5 g, 68.9 mmol) were dissolved in acetone (70 mL) and MeI (7.5 g, 51.8 mmol) was added at room temperature. The reaction solution was stirred at 45 °C for 12 hours. Upon completion of the reaction, the mixture was washed with water and saturated NaCl solution, dried over Na2SO4 and concentrated to give methyl 4-(tert-butoxycarbonylamino)butyrate (6.2 g, 83%) as a yellow oil.ESI-MS (EI+, m/z): 240 [M + Na]+.
References
[1] Patent: WO2013/149121, 2013, A1. Location in patent: Page/Page column 75; 76
[2] Patent: US2015/111864, 2015, A1. Location in patent: Paragraph 0113; 0115
[3] Farmaco, 2004, vol. 59, # 5, p. 381 - 388
[4] Organic and Biomolecular Chemistry, 2012, vol. 10, # 4, p. 861 - 868
4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Suppliers
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- Product
- 4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester 85909-04-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-99.9%
- Supply Ability
- 100kg
- Release date
- 2020-01-10