KIN1408

Product Name: KIN1408
CAS No.: 1903800-11-2
Chemical Name: KIN1408
Synonyms: KIN1408;KIN-1408 (KIN-1408;KIN1408 >=98% (HPLC);8-Quinolinol, 7-[[4-(difluoromethoxy)phenyl][(5-methoxy-2-benzothiazolyl)amino]methyl]-;7-((4-(difluoromethoxy)phenyl)((5-methoxybenzo[d]thiazol-2-yl)amino)methyl)quinolin-8-ol);KIN-1408;KIN 1408;7-((4-(DIFLUOROMETHOXY)PHENYL)((5-METHOXYBENZO[D]THIAZOL-2-YL)AMINO)METHYL)QUINOLIN-8-OL
CBNumber: CB43121111
Molecular Formula: C25H19F2N3O3S
Formula Weight: 479.5
MOL File: 1903800-11-2.mol

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KIN1408 Property

Boiling point:: 675.6±65.0 °C(Predicted)
Density: 1.430±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:34.5(Max Conc. mg/mL);71.95(Max Conc. mM)
form: A solid
pka: 4.22±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21790
Product name: KIN1408
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 21790
Product name: KIN1408
Purity: ≥98%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

ChemScene

Product number: CS-5477
Product name: KIN1408
Purity: 99.55%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: 2008EG
Product name: 7-[[4-(Difluoromethoxy)phenyl]-[(5-methoxy-1,3-benzothiazol-2-yl)amino]methyl]quinolin-8-ol
Packaging: 5mg
Price: $201
Updated: 2021/12/16

ChemScene

Product number: CS-5477
Product name: KIN1408
Purity: 99.55%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

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KIN1408 Chemical Properties,Usage,Production

Description

KIN1408 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity. It induces interferon regulatory factor 3 (IRF3) activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity. KIN1408 induces expression of the innate immune genes MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA; ). It exhibits concentration-dependent broad-spectrum antiviral activity against dengue virus 2 as well as the influenza A, Ebola, Nipah, and Lassa viruses.

Uses

KIN1408 is an agonist of the RIG-1-like receptor (RLR) pathway and exhibits a broad-spectrum antiviral activity. KIN1408 exhibits activity against HCV, influenza A, dengue virus 2, Ebola, Nipah, and Lassa viruses[1][2].

References

[1] Green RR, et al. Transcriptional analysis of antiviral small molecule therapeutics as agonists of the RLR pathway. Genom Data. 2016 Feb 1;7:290-2. DOI:10.1016/j.gdata.2016.01.020
[2] Sowmya Pattabhi, et al. Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway. J Virol. 2015 Dec 16;90(5):2372-87. DOI:10.1128/JVI.02202-15

KIN1408 Preparation Products And Raw materials

Raw materials

Preparation Products

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KIN1408 Suppliers

China 29 United States 6 Global 35

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1903800-11-2, KIN1408Related Search:

7-((4-(difluoromethoxy)phenyl)((5-methoxybenzo[d]thiazol-2-yl)amino)methyl)quinolin-8-ol)

KIN-1408 (KIN-1408

KIN-1408;KIN 1408;7-((4-(DIFLUOROMETHOXY)PHENYL)((5-METHOXYBENZO[D]THIAZOL-2-YL)AMINO)METHYL)QUINOLIN-8-OL

KIN1408

8-Quinolinol, 7-[[4-(difluoromethoxy)phenyl][(5-methoxy-2-benzothiazolyl)amino]methyl]-

KIN1408 >=98% (HPLC)

1903800-11-2

C25H19F2N3O3S