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BPO-27 (racemate)

Product Name
BPO-27 (racemate)
CAS No.
1314873-02-3
Chemical Name
BPO-27 (racemate)
Synonyms
BPO-27 racemat;BPO-27 (racemate);BPO-27 racemate, 10 mM in DMSO;BPO 27 RACEMATE; BPO27 RACEMATE;Inhibitor,Cystic fibrosis transmembrane conductance regulator,inhibit,BPO27 racemate,Autophagy,BPO-27,BPO 27,BPO 27 racemate,BPO27,CFTR;6H-Pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, 6-(5-bromo-2-furanyl)-7,8,9,10-tetrahydro-7,9-dimethyl-8,10-dioxo-11-phenyl-;6-(5-bromofuran-2-yl)-7,9-dimethyl-8,10-dioxo-11-phenyl-7,8,9,10-tetrahydro-6H-benzo[b]pyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazine-2-carboxylic acid
CBNumber
CB43167599
Molecular Formula
C26H18BrN3O6
Formula Weight
548.34
MOL File
1314873-02-3.mol
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BPO-27 (racemate) Property

Boiling point:
732.9±70.0 °C(Predicted)
Density 
1.68±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 6 mg/mL (10.94 mM)
form 
Solid
pka
3.76±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6271
Product name
BPO-27racemate
Purity
98.37%
Packaging
1mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-6271
Product name
BPO-27racemate
Purity
98.37%
Packaging
5mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-6271
Product name
BPO-27racemate
Purity
98.37%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-6271
Product name
BPO-27racemate
Purity
98.37%
Packaging
50mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-6271
Product name
BPO-27racemate
Purity
98.37%
Packaging
100mg
Price
$2520
Updated
2021/12/16
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BPO-27 (racemate) Chemical Properties,Usage,Production

Uses

BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM.

in vivo

Following bolus interperitoneal administration in mice, serum (R)-1 decays with t1/2 ≈ 1.6 h and gives sustained therapeutic concentrations in kidney[1].

References

[1] Snyder DS, et al. Absolute Configuration And Biological Properties of Enantiomers of CFTR Inhibitor BPO-27. ACS Med Chem Lett. 2013 May 9;4(5):456-459. DOI:10.1021/ml400069k
[2] Kim Y, et al. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88(4):689-96. DOI:10.1124/mol.115.098368

BPO-27 (racemate) Preparation Products And Raw materials

Raw materials

Preparation Products

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BPO-27 (racemate) Suppliers

China 22 United States 4 USA 1 Global 27
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
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+86-21-61629029
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product02@bidepharm.com
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China
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42446
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Kaixin Chemical (Hong Kong) Limited
Tel
010-88886666-01 13112345678
Fax
CDXH21@126.com
Email
loyson@tcypharm.com
Country
China
ProdList
597
Advantage
55
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
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China
ProdList
9729
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58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
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86-571-88216895
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sales@hzclap.com
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CHINA
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
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sales@chemegen.com
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China
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Absin Bioscience Inc.
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021-38015121 18438616290
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lanwu@univ-bio.com
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Suzhou Zhixin Biotechnology Co., Ltd.
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0512-65118909 18100677375
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sales@szzxbio.com
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China
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Taizhou GreenChem Pharma-Tech Co.,Ltd
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greenchem@tzglmk.com
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China
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Nantong QuanYi Biotechnology Co., Ltd
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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Nanjing Shizhou Biology Technology Co.,Ltd
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RD International Technology Co., Limited
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market@ubiochem.com
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China
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Sangon Biotech (Shanghai) Co.,Ltd.
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Biosynth Biological Technology (Suzhou) Co Ltd
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Guangzhou Baben Biotechnology Co., Ltd.
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Absin Bioscience Inc.
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Proteintech China
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1314873-02-3, BPO-27 (racemate)Related Search:


  • BPO-27 (racemate)
  • BPO 27 RACEMATE; BPO27 RACEMATE
  • BPO-27 racemat
  • 6H-Pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, 6-(5-bromo-2-furanyl)-7,8,9,10-tetrahydro-7,9-dimethyl-8,10-dioxo-11-phenyl-
  • Inhibitor,Cystic fibrosis transmembrane conductance regulator,inhibit,BPO27 racemate,Autophagy,BPO-27,BPO 27,BPO 27 racemate,BPO27,CFTR
  • 6-(5-bromofuran-2-yl)-7,9-dimethyl-8,10-dioxo-11-phenyl-7,8,9,10-tetrahydro-6H-benzo[b]pyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazine-2-carboxylic acid
  • BPO-27 racemate, 10 mM in DMSO
  • 1314873-02-3
  • C26H18BrN3O6