ChemicalBook > CAS DataBase List > Methyl 2,4-dichloropyrimidine-6-carboxylate

Methyl 2,4-dichloropyrimidine-6-carboxylate

Product Name
Methyl 2,4-dichloropyrimidine-6-carboxylate
CAS No.
6299-85-0
Chemical Name
Methyl 2,4-dichloropyrimidine-6-carboxylate
Synonyms
Methyl 2,6-dichloropyrimidine-4-carboxylate;2,6-Dichloro-pyrimidine-4-carboxylic acid methyl ester;6-c;NSC45044;2-(3-CHLOROPHENYL)MALONDIALDEHYDE;2,6-dichloropyrimidine-4-carboxylate;2,4-dichloropyrimidine-6-carboxylate;2-(3-chlorophenyl)malondialdehyde,98%;2,4-Dichloro-6-(methoxycarbonyl)pyrimidine;Methyl 2,6-dichloropyrimidin-4-carboxylate
CBNumber
CB4326700
Molecular Formula
C6H4Cl2N2O2
Formula Weight
207.01
MOL File
6299-85-0.mol
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Methyl 2,4-dichloropyrimidine-6-carboxylate Property

Melting point:
54-56
Boiling point:
306 ºC
Density 
1.503
Flash point:
139 ºC
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
White to off white to faint cream flakes
pka
-5.83±0.30(Predicted)
Appearance
Off-white to yellow Solid
InChI
InChI=1S/C6H4Cl2N2O2/c1-12-5(11)3-2-4(7)10-6(8)9-3/h2H,1H3
InChIKey
DQNQNLWKAGZNIT-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC(C(OC)=O)=N1
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
M301390
Product name
Methyl2,4-dichloropyrimidine-6-carboxylate
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
M301390
Product name
Methyl2,4-dichloropyrimidine-6-carboxylate
Packaging
500mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
J94908
Product name
Methyl2,4-Dichloro-pyrimidine-6-carboxylate
Packaging
1g
Price
$10
Updated
2021/12/16
Oakwood
Product number
023426
Product name
Methyl2,4-dichloropyrimidine-6-carboxylate
Purity
98%
Packaging
1g
Price
$10
Updated
2021/12/16
Oakwood
Product number
023426
Product name
Methyl2,4-dichloropyrimidine-6-carboxylate
Purity
98%
Packaging
5g
Price
$25
Updated
2021/12/16
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Methyl 2,4-dichloropyrimidine-6-carboxylate Chemical Properties,Usage,Production

Synthesis

To a stirred suspension of orotic acid (20.00 g, 128.140 mmol) in POCI3(75 ml) was added DMF (catalytic amount, -0.5 ml) at ambient temperature, and the resulting reaction mixture was refluxed for 3 h. Excess of POC was removed by vacuum distillation after 3h of reflux. The obtained slurry was poured slowly into a 5 per cent mixture of methanol in chloroform (200 ml) at 0°C and stirred for 30 min. The organic layer obtained was washed with a saturated solution of NaHCC>3 (3 x 200 ml). The combined organic phase was dried over Na2S04, filtered and concentrated under reduced pressure, yielding Methyl 2,4-dichloropyrimidine-6-carboxylate (19.00 g, 91 .800 mmol).

References

[1] Patent: WO2018/167276, 2018, A1. Location in patent: Paragraph 00131; 00132; 00133

Methyl 2,4-dichloropyrimidine-6-carboxylate Preparation Products And Raw materials

Raw materials

Heptane N,N-Dimethylformamide Sodium sulfate Phosphorus oxitrichloride Orotic acid Diethyl ether Benzene Methanol Thionyl chloride Activated carbon

Preparation Products

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Methyl 2,4-dichloropyrimidine-6-carboxylate Suppliers

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View Lastest Price from Methyl 2,4-dichloropyrimidine-6-carboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-(3-CHLOROPHENYL)MALONDIALDEHYDE 6299-85-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-22
Shaanxi Dideu Medichem Co. Ltd
Product
2,6-dichloropyrimidine-4-carboxylate 6299-85-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14
Career Henan Chemical Co
Product
2-(3-CHLOROPHENYL)MALONDIALDEHYDE 6299-85-0
Price
US $3500.00-3200.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
100kg
Release date
2018-08-03

6299-85-0, Methyl 2,4-dichloropyrimidine-6-carboxylateRelated Search:

Sulfadiazine 2,4-Dichloropyrimidine 2-(4-CHLOROPHENYL)MALONDIALDEHYDE 95% 2-(4-CHLOROPHENYL)MALONDIALDEHYDE, 95,2-(2-Chlorophenyl)malondialdehyde 2-(4-CHLOROPHENYL)MALONDIALDEHYDE PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER 2-(3-CHLOROPHENYL)MALONDIALDEHYDE 2-Chloropyrimidine-4-carboxylic acid ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE 4-PYRIMIDINECARBOXALDEHYDE, 2,6-DICHLORO- METHYL 2,4-DICHLOROPYRIMIDINE-6-CARBOXYLATE 2,4-Dichloro-6-methylpyrimidine

  • 2,6-DICHLORO-PYRIMIDINE-4-CARBOXYLIC ACID ETHYL ESTER
  • 2,6-Dichloro-pyrimidine-4-carboxylic acid methyl ester
  • NSC45044
  • Methyl 2,4-dichloropyrimidine-6-carboxylate 99%
  • Methyl2,4-dichloropyrimidine-6-carboxylate99%
  • 2-(3-CHLOROPHENYL)MALONDIALDEHYDE
  • 4-Methyl-2-(3,4-dichlorophenyl)thiazole-5-carboxylicacid
  • Methyl 2,4-dichloropyrimidine-6-carboxylate
  • 4-PyriMidinecarboxylicacid, 2,6-dichloro-, Methyl ester
  • 2,4-Dichloro-6-(methoxycarbonyl)pyrimidine
  • Methyl 2,6-dichloropyrimidine-4-carboxylate
  • 2,6-dichloropyrimidine-4-carboxylate
  • 2,4-dichloropyrimidine-6-carboxylate
  • Tert-butyl n-(2-(4-nitrophenyl)ethyl)carbamate
  • 6-c
  • 2-(3-chlorophenyl)malondialdehyde,98%
  • Methyl 2,6-dichloropyrimidin-4-carboxylate
  • 6299-85-0
  • 6299-45-0
  • Heterocycle-Pyrimidine series
  • pharmacetical