CBZ-AEP
- Product Name
- CBZ-AEP
- CAS No.
- 1205751-19-4
- Chemical Name
- CBZ-AEP
- Synonyms
- CBZ-AEP;CBZ-NH-PEG1-acid;CBZ-NH-PEG1-propionic acid;3-[2-(Cbz-amino)ethoxy]propanoic acid;3-(2-(((benzyloxy)carbonyl)amino)ethoxy)propanoic acid;Propanoic acid, 3-[2-[[(phenylmethoxy)carbonyl]amino]ethoxy]-;inhibit,Cbz NH PEG1 CH2CH2COOH,Inhibitor,PROTAC Linkers,Cbz-NH-PEG-1-CH2CH2COOH,CbzNHPEG1CH2CH2COOH
- CBNumber
- CB43340587
- Molecular Formula
- C13H17NO5
- Formula Weight
- 267.28
- MOL File
- 1205751-19-4.mol
CBZ-AEP Property
- Boiling point:
- 476.2±40.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Solid
- pka
- 4.29±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4327901
- Product name
- CBZ-AEP
- Purity
- min.95%
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- B-1095
- Product name
- 3-[2-(Cbz-amino)ethoxy]propanoicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $495
- Updated
- 2021/12/16
CBZ-AEP Chemical Properties,Usage,Production
Description
3-[2-(Cbz-amino)ethoxy]propanoic acid is a PEG linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
Uses
Cbz-NH-PEG1-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
CBZ-AEP Preparation Products And Raw materials
Raw materials
Preparation Products
CBZ-AEP Suppliers
- Tel
- 010-010-82967028 13522913783
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- +86-10-82967029
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- China
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- +86-21-61629029
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- China
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- China
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- 0512-56316826
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- United States
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- +86-0571-81612335 +8613336028439
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View Lastest Price from CBZ-AEP manufacturers
- Product
- CBZ-NH-PEG1-CH2CH2COOH 1205751-19-4
- Price
- US $134.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2025-11-24