ChemicalBook > CAS DataBase List > 3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE

Product Name
3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE
CAS No.
676599-90-9
Chemical Name
3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE
Synonyms
APHA-8;MC1353;MC-1353;MC 1353;APHA COMPOUND 8;Aroyl pyrrole hydroxy amide #8;3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE;(E)-N-hydroxy-3-(1-Methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl)acrylaMide;2-Propenamide, N-hydroxy-3-[1-methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl]-
CBNumber
CB4360159
Molecular Formula
C16H16N2O3
Formula Weight
284.31
MOL File
676599-90-9.mol
More
Less

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Property

storage temp. 
2-8°C
solubility 
DMSO: 10 mg/mL, soluble
form 
solid
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-41-43
Safety Statements 
26-36/37/39
WGK Germany 
2
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A2478
Product name
APHA Compound 8
Purity
≥98% (HPLC), solid
Packaging
1mg
Price
$156
Updated
2024/03/01
Cayman Chemical
Product number
21228
Product name
APHA Compound 8
Packaging
500μg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
21228
Product name
APHA Compound 8
Packaging
1mg
Price
$92
Updated
2024/03/01
AK Scientific
Product number
3575DN
Product name
3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
Packaging
1mg
Price
$199
Updated
2021/12/16
More
Less

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Chemical Properties,Usage,Production

Description

APHA compound 8 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 3.7, 7.4, 0.42, and 2.8 μM for HDAC1, -2, -3, and -8, respectively) as well as class II HDACs (IC50s = 3.1, 0.1, 3.1, and 4.2 μM for HDAC4, -6, -7, and -10, respectively). It is selective for class I and II HDACs over class III HDACs (IC50s = >30 μM for SIRT1, SIRT2, and SIRT3) and the histone acetyltransferase PCAF (IC50 = >30 μM). At 48 hours post-infection, APHA compound 8 increases replication of oncolytic herpes simplex virus (oHSV) in MDA-MB-231 and 4T1 breast cancer cells when used prior to viral infection at concentrations of 10 and 50 μM.

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Suppliers

CHINA 16 Switzerland 1 United States 8 USA 1 Global 26
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91

676599-90-9, 3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDERelated Search:


  • 3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE
  • APHA COMPOUND 8
  • (E)-N-hydroxy-3-(1-Methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl)acrylaMide
  • 2-Propenamide, N-hydroxy-3-[1-methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl]-
  • APHA-8
  • Aroyl pyrrole hydroxy amide #8
  • MC 1353
  • MC1353
  • MC-1353
  • 676599-90-9
  • Biochemicals and Reagents
  • BioChemical
  • Histone deacetylase
  • D to K
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • Histone Deacetylase (HDAC) inhibitor.