N,N-Dimethylglycine
- Product Name
- N,N-Dimethylglycine
- CAS No.
- 1118-68-9
- Chemical Name
- N,N-Dimethylglycine
- Synonyms
- DMG;DIMETHYLGLYCINE;AKOS BB-5614;n-methylsarcosine;N-DiMethylglycine;N,N-Dimthylglycine;N. N-methylglycine;RARECHEM AL BO 0104;N,N-DIMETHYLGLYCINE;n,n-dimethyl-glycin
- CBNumber
- CB4440420
- Molecular Formula
- C4H9NO2
- Formula Weight
- 103.12
- MOL File
- 1118-68-9.mol
N,N-Dimethylglycine Property
- Melting point:
- 178-182 °C(lit.)
- Boiling point:
- 193.35°C (rough estimate)
- Density
- 1 g/cm3
- refractive index
- 1.4674 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Methanol (Slightly), Water (Slightly)
- pka
- 9.89(at 25℃)
- form
- Crystalline Powder
- color
- White to slightly yellow
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- Merck
- 14,3244
- BRN
- 1700261
- InChIKey
- FFDGPVCHZBVARC-UHFFFAOYSA-N
- CAS DataBase Reference
- 1118-68-9(CAS DataBase Reference)
- EPA Substance Registry System
- Glycine, N,N-dimethyl- (1118-68-9)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 24/25-36/37-26
- WGK Germany
- 3
- RTECS
- MB9865000
- F
- 3
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29224999
- Toxicity
- rat,LD50,oral,> 650mg/kg (650mg/kg),BEHAVIORAL: ATAXIABLOOD: CHANGES IN SPLEENGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 199, 1992.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 05022
- Product name
- N,N-Dimethylglycine
- Purity
- for HPLC derivatization, ≥99% (NT)
- Packaging
- 1g
- Price
- $59.8
- Updated
- 2022/05/15
- Product number
- 05022
- Product name
- N,N-Dimethylglycine
- Purity
- for HPLC derivatization, ≥99% (NT)
- Packaging
- 10x1g
- Price
- $469
- Updated
- 2022/05/15
- Product number
- D3585
- Product name
- N,N-Dimethylglycine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- D3585
- Product name
- N,N-Dimethylglycine
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $158
- Updated
- 2025/07/31
- Product number
- D1156
- Product name
- N,N-Dimethylglycine
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $32.7
- Updated
- 2025/07/31
N,N-Dimethylglycine Chemical Properties,Usage,Production
Description
N,N-Dimethylglycine (DMG) is a N-methylated product of the amino acid glycine. It is found in beans and liver. It can be formed from trimethylglycine upon the loss of one of its methyl groups. It is also a byproduct of the metabolism of choline. When DMG was first discovered, it was referred to as vitamin B16, but, unlike true B vitamins, deficiency of DMG in the diet does not lead to any ill-effects meaning it does not meet the definition of a vitamin. It is used in comparative analysis with other N-methylated glycines. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers, and as a substrate to identify, differentiate and characterize amino acid methyltransferase(s). It is potentially useful as a biomarker of protein degradation in COPD patients.
Chemical Properties
white to slightly yellow crystalline powder
History
N,N-Dimethylglycine was discovered in 1943. It is found in some but not all formulations of pangamic acid (vitamin B15). Pangamic acid has been sold as a dietary supplement in the United States at least since the late 1970s, when the lay press celebrated its benefits. Although pangamic acid is also known as vitamin B16, it is not actually a vitamin because no deficiency state has been identified, and it has no known nutritional value.
Synthesis
The preparation method of N,N-Dimethylglycine comprises the following steps of: preparing N,N-dimethyl amino acetonitrile by taking hydroxyacetonitrile and dimethylamine as raw materials, obtaining an N,N-dimethylglycine crude product by alkalizing the reaction liquid with an inorganic base and neutralizing the reaction liquid with an organic acid on the basis of N,N-dimethyl amino acetonitrile reaction liquid, and finally separating and purifying the N,N-dimethylglycine crude product to obtain the high-quality N,N-dimethylglycine product.
Uses
N,N-Dimethylglycine is used as an athletic performance enhancer and immunostimulant. It is also used in the treatment of autism, epilepsy and mitochondrial disease. It is also employed as a biomarker of protein degradation in chronic obstructive lung disease (COPD) patients. Further, it is used as a substrate to identify, differentiate and characterize amino acid methyltransferase. It plays an important role for the development of glycine-based ionic liquids and emulsifiers.
Application
N, N-dimethylglycine (DMG) is a tertiary amino acid that naturally occurs as an intermediate metabolite in choline-to-glycine metabolism. It has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease . Published studies on the subject have shown little to no difference between DMG treatment and placebo in autism spectrum disorders.
Definition
ChEBI: N,N-dimethylglycine is an N-methylglycine that is glycine carrying two N-methyl substituents. It has a role as a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a N-methyl-amino acid and a member of N-methylglycines. It is a tautomer of a N,N-dimethylglycine zwitterion.
Preparation
N,N-Dimethylglycine is commercially available as the free form amino acid, and as the hydrochloride salt [2491-06-7 ]. DMG may be prepared by the alkylation of glycine via the Eschweiler–Clarke reaction. In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant. Hydrochloric acid is added thereafter to give the hydrochloride salt. The free amino acid may been obtained by neutralization of the acid salt, which has been performed with silver oxide.
H2NCH2COOH + 2 CH2O + 2 HCOOH →(CH3)2NCH2COOH + 2 CO2 + 2 H2O.
General Description
N,N-Dimethylglycine is a type of quaternary ammonium compound which exhibits a variety of biological effects.
Biochem/physiol Actions
N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).
References
J. K. Kern, V. S. Miller, L. Cauller, R. Kendall, J. Mehta, M. Dodd, Effectiveness of N,N-Dimethylglycine in Autism and Pervasive Developmental Disorder, Journal of Child Neurology, 2001, vol. 16, pp. 169-173
N,N-Dimethylglycine Preparation Products And Raw materials
Raw materials
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View Lastest Price from N,N-Dimethylglycine manufacturers
- Product
- N,N-Dimethylglycine 1118-68-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100tons
- Release date
- 2025-11-20
- Product
- N,N-Dimethylglycine 1118-68-9
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1000kg
- Release date
- 2021-12-09
- Product
- N,N-Dimethylglycine 1118-68-9
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100 tons
- Release date
- 2024-08-14