ChemicalBook > CAS DataBase List > 1,4-Butanediol

1,4-Butanediol

Product Name
1,4-Butanediol
CAS No.
110-63-4
Chemical Name
1,4-Butanediol
Synonyms
BDO;Butylene glycol;Butanediol;BUTANE-1,4-DIOL;TETRAMETHYLENE GLYCOL;1,4-Butandiol;1,4-BD;sucolb;Diol 14B;4-Butanediol
CBNumber
CB4452184
Molecular Formula
C4H10O2
Formula Weight
90.12
MOL File
110-63-4.mol
More
Less

1,4-Butanediol Property

Melting point:
16 °C (lit.)
Boiling point:
230 °C (lit.)
Density 
1.017 g/mL at 25 °C (lit.)
vapor density 
3.1 (vs air)
vapor pressure 
<0.1 hPa (20 °C)
refractive index 
n20/D 1.445(lit.)
Flash point:
135 °C
storage temp. 
Store below +30°C.
pka
14.73±0.10(Predicted)
form 
Liquid
color 
Clear colorless
Odor
Odorless
PH
7-8 (500g/l, H2O, 20℃)
explosive limit
1.95-18.3%(V)
Water Solubility 
Miscible
Sensitive 
Hygroscopic
BRN 
1633445
Dielectric constant
30.0（30℃）
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, mineral acids, acid chlorides, acid anhydrides.
InChIKey
WERYXYBDKMZEQL-UHFFFAOYSA-N
LogP
-0.88 at 25℃
Surface tension
45.33mN/m at 298.15K
CAS DataBase Reference
110-63-4(CAS DataBase Reference)
NIST Chemistry Reference
1,4-Butanediol(110-63-4)
EPA Substance Registry System
1,4-Butanediol (110-63-4)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-67
Safety Statements 
36-23-24/25
WGK Germany 
1
RTECS 
EK0525000
Autoignition Temperature
698 °F
TSCA 
Yes
HS Code 
29053980
Hazardous Substances Data
110-63-4(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1525 mg/kg LD50 dermal Rabbit > 2000 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.01532
Product name
1,4-Butanediol
Purity
for synthesis
Packaging
1l
Price
$49.8
Updated
2025/07/31
Sigma-Aldrich
Product number
8.01532
Product name
1,4-Butanediol
Purity
for synthesis
Packaging
2.5L
Price
$491
Updated
2025/07/31
Sigma-Aldrich
Product number
240559
Product name
1,4-Butanediol
Purity
≥99%
Packaging
2g
Price
$36.4
Updated
2025/07/31
Sigma-Aldrich
Product number
240559
Product name
1,4-Butanediol
Purity
≥99%
Packaging
100g
Price
$107
Updated
2025/07/31
Sigma-Aldrich
Product number
493732
Product name
1,4-Butanediol
Purity
99%
Packaging
1l
Price
$47
Updated
2025/07/31
More
Less

1,4-Butanediol Chemical Properties,Usage,Production

Chemical Properties

1,4-butanediol (1,4-BD) is a colorless, viscous liquid derived from butane by placement of alcohol groups at each end of its molecular chain and is one of four stable isomers of butanediol.the hydroxyl function of each end group of the Butanediol reacts with different mono- and bifunctional reagents: for example with dicarboxylic acids to polyesters, with diisocyanates to polyurethanes, or with phosgene to polycarbonates. 1.4-Butanediol (BDO) is a high-quality intermediate. BDO and its derivatives are widely used for producing plastics, solvents, electronic chemicals and elastic fibers. Additionally BDO is also a building block for the synthesis of polyesterpolyols and polyetherpolyols. BASF is the most significant producer of 1,4-Butanediol and its derivatives worldwide.

Uses

  1. Butanediol and its derivatives is used in a broad spectrum of applications in the chemical industry; amongst others in the manufacturing of technical plastics, polyurethanes, solvents, electronic chemicals and elastic fibres.
  2. 1,4-Butanediol is used in the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide.
  3. 1,4-Butanediol's largest use is within tetrahydrofuran (THF) production, used to make polytetramethylene ether glycol, which goes mainly into spandex fibers, urethane elastomers, and copolyester ethers.
  4. It is commonly used as a solvent in the chemical industry to manufacture gamma-butyrolactone and elastic fibers like spandex.
  5. It is used as a cross-linking agent for thermoplastic urethanes, polyester plasticizers, paints and coatings.
  6. It undergoes dehydration in the presence of phosphoric acid yielded teterahydrofuran, which is an important solvent used for various applications.
  7. It acts an intermediate and is used to manufacture polytetramethylene ether glycol (PTMEG), polybutylene terephthalate (PBT) and polyurethane (PU).
  8. It finds application as an industrial cleaner and a glue remover.
  9. 1,4-butanediol is also used as a plasticiser (e.g. in polyesters and cellulosics), as a carrier solvent in printing ink, a cleaning agent, an adhesive (in leather, plastics, polyester laminates and polyurethane footwear), in agricultural and veterinary chemicals and in coatings (in paints, varnishes and films).

Uses

butylene glycol is a solvent with good antimicrobial action. It enhances the preservative activity of parabens. Butylene glycol also serves as a humectant and viscosity controller, and to mask odor.

Uses

1,4-Butanediol is used to produce polybutyleneterephthalate, a thermoplastic polyester;and in making tetrahydrofuran, butyrolactones,and polymeric plasticizers.

Definition

ChEBI: Butane-1,4-diol is a butanediol that is butane in which one hydrogen of each of the methyl groups is substituted by a hydroxy group. A colourless, water-miscible, viscous liquid at room temperature (m.p. 16℃) with a high boiling point (230℃), it is mainly used for the production of other organic chemicals, particularly the solvent oxolane (also known as tetrahydrofuran or THF). It has a role as a neurotoxin, a protic solvent and a prodrug. It is a butanediol and a glycol.

Production Methods

Methods of manufacturing:
The most prevalent 1,4-BD production route worldwide is BASF's Reppe process, which reacts acetylene and formaldehyde. Acetylene reacts with two equivalents of formaldehyde to form 1,4-butynediol, also known as but-2-yne- 1,4-diol. Hydrogenation of 1,4-butynediol gives 1,4-butanediol. 1,4-BD is also made on a large industrial scale by continuous hydrogenation of the 2-butyne- 1,4-diol over modified nickel catalysts. The one-stage flow process is carried out at 80 - 160°C and 300 bar.
Mitsubishi uses a three-step process:
(1) the catalytic reaction of butadiene and acetic acid yields 1,4-diacetoxy-2-butene;
(2) subsequent hydrogenation gives 1,4-diacetoxybutane; and
(3) hydrolysis leads to 1,4-butanediol.

Synthesis Reference(s)

The Journal of Organic Chemistry, 36, p. 2018, 1971 DOI: 10.1021/jo00813a043
Tetrahedron Letters, 33, p. 6371, 1992 DOI: 10.1016/S0040-4039(00)60976-0

General Description

Odorless colorless liquid or solid (depending upon temperature).

Air & Water Reactions

Highly flammable. 1,4-Butanediol is hygroscopic. Water soluble.

Reactivity Profile

1,4-Butanediol is heat and light sensitive. 1,4-Butanediol reacts with acid chlorides, acid anhydrides and chloroformates; reacts with oxidizing agents and reducing agents. 1,4-Butanediol is incompatible with isocyanates and acids; also incompatible with peroxides, perchloric acid, sulfuric acid, hypochlorous acid, nitric acid, caustics, acetaldehyde, nitrogen peroxide and chlorine.

Hazard

Toxic by ingestion.

Health Hazard

The acute toxic effects are mild. 1,4-Butanediolis less toxic than its unsaturate analogs,butenediol and the butynediol. The oralLD50 value in white rats and guinea pigsis ~2 mL/kg. The toxic symptoms fromingestion may include excitement, depressionof the central nervous system, nausea, anddrowsiness.

Health Hazard

Ingestion of large amounts needed to produce any symptoms.

Fire Hazard

Nonflammable liquid, flash point (open cup) 121°C.

Safety Profile

A human poison by an unspecified route. Moderately toxic byingestion and intraperitoneal routes. Human systemic effects: altered sleep time. Combustible when exposed to heat or flame. To fight fire, use alcohol foam, mist, foam, CO2, dry chemical. Incompatible with oxidizing materials. When heated to decomposition it emits acrid smoke and fumes.

Solubility in water

1,4-Butanediol is soluble in water, alcohols, esters, ketones, glycol ethers and glycol ether acetates (Butanediols, Butenediol, and Butynediol).

Purification Methods

Distil the glycol and store it over Linde type 4A molecular sieves, or crystallise it twice from anhydrous diethyl ether/acetone, and redistil it. It has been recrystallised from the melt and doubly distilled in vacuo in the presence of Na2SO4. [Beilstein 1 IV 2515.]

Toxics Screening Level

The Initial Risk Screening Level (ITSL) for 1,4-butanediol (CAS# 110-63-4) is 79 μg/m3 based on annual averaging time.

1,4-Butanediol Preparation Products And Raw materials

Raw materials

1,3-Butadiene 2,3-Butanedione Formaldehyde Nickel 2-chloro-1,3-butadiene 2-Butyne-1,4-diol Acetylene cis-1,4-Dichloro-2-butene

Preparation Products

Poly(butylene terephthalate) Polyurethane Busulfan PolyesterPolyol Polyurethane adhesive 4-Hydroxybutyl acrylate Polyvinylpyrrolidone 2,3-Dihydrofuran GD visible light curing composite resin Tetrahydrofuran 1,4-Dibromobutane Triethylene glycol dimethacrylate 1,4-BUTANEDIOL DIACRYLATE Gamma Butyrolactone
More
Less

1,4-Butanediol Suppliers

Australia 3 Belgium 6 Canada 4 China 625 Europe 5 France 6 Germany 23 Hungary 2 India 55 Italy 3 Japan 10 Malaysia 4 Poland 1 Saudi Arabia 1 Singapore 1 Slovakia 1 South Korea 3 Spain 2 Switzerland 1 The Netherlands 7 Turkey 1 Ukraine 2 United Arab Emirates 1 United Kingdom 12 United States 77 USA 1 Global 857
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aston Chemical
Tel
13000000000
Email
sales@astonchem.com
Country
United States
ProdList
1634
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
ICC Chemical Corporation (a subsidiary of ICC Industries Inc.)
Tel
--
Fax
--
Email
fkt@iccchem.com
Country
United States
ProdList
113
Advantage
58
Redox Scientific
Tel
--
Fax
--
Email
info@redoxsci.com
Country
United States
ProdList
2380
Advantage
58
Alchem Chemical Company
Tel
--
Fax
--
Country
United States
ProdList
54
Advantage
58
Ashland Global Specialty Chemicals Inc.
Tel
--
Fax
--
Email
ashland@ashland.com
Country
United States
ProdList
17
Advantage
58
Sandrine Corporation
Tel
--
Fax
--
Email
sandrine@earthlink.net
Country
United States
ProdList
26
Advantage
58
Crescent Chemical Company
Tel
--
Fax
--
Email
fran@creschem.com
Country
United States
ProdList
1441
Advantage
58
Whitaker Oil Company
Tel
--
Fax
--
Email
sales@whitakeroil.com
Country
United States
ProdList
43
Advantage
58
BASF SE
Tel
--
Fax
--
Email
jennifer.moore-braun@basf.com
Country
United States
ProdList
285
Advantage
58
2A Biotech USA
Tel
--
Fax
--
Email
info@2abiotech.com
Country
United States
ProdList
1785
Advantage
58
TCI America, Inc. (Tokyo Chemical Industry Co., Ltd.)
Tel
--
Fax
--
Email
.Crew@tcichemicals.com
Country
United States
ProdList
3164
Advantage
58
Coyne Chemical
Tel
--
Fax
--
Email
csr@coynechemical.com
Country
United States
ProdList
82
Advantage
58
Callahan Chemical Company
Tel
--
Fax
--
Email
SLakhan@calchem.com
Country
United States
ProdList
62
Advantage
58
Aozeal Certified Standards (AOCS), Inc.
Tel
--
Fax
--
Email
info@aozeal.com
Country
United States
ProdList
504
Advantage
58
Greenchem Industries LLC
Tel
--
Fax
--
Email
info@greenchemindustries.com
Country
United States
ProdList
61
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
JEEN International Corporation
Tel
--
Fax
--
Email
info@jeen.com
Country
United States
ProdList
47
Advantage
58
Astro Chemicals, Inc.
Tel
--
Fax
--
Email
customer.service@astrochemicals.com
Country
United States
ProdList
52
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Tedia Company, Inc.
Tel
--
Fax
--
Email
sales@tedia.com
Country
United States
ProdList
50
Advantage
58
MP Biomedicals, LLC. (Division of Valiant FC Co., Ltd.)
Tel
--
Fax
--
Email
serv@mpbio.com
Country
United States
ProdList
1854
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
First Continental International (FCI)
Tel
--
Fax
--
Email
sales@fci-nj.com
Country
United States
ProdList
178
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
Gantrade Corporation
Tel
--
Fax
--
Email
raltman@gantrade.com
Country
United States
ProdList
27
Advantage
58
Darwin Chemical Company
Tel
--
Fax
--
Email
shipping@darwinchemical.com
Country
United States
ProdList
69
Advantage
43
Qingdao Free Trade Zone United International Co Ltd
Tel
--
Fax
--
Email
info@unitedint.com
Country
United States
ProdList
604
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
HBCChem, Inc.
Tel
--
Fax
--
Email
Sales@hbcchem-inc.com
Country
United States
ProdList
887
Advantage
50
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Cerilliant Corporation
Tel
--
Fax
--
Email
techserv@cerilliant.com
Country
United States
ProdList
1629
Advantage
69
Advanced Synthesis Technologies
Tel
--
Fax
--
Email
sales@advancedsynthesis.com
Country
United States
ProdList
4775
Advantage
61
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Leonid Chemicals Private Limited
Tel
--
Fax
--
Email
careers@leonidchemicals.com
Country
United States
ProdList
1700
Advantage
43
BASF Corporation
Tel
--
Fax
--
Country
United States
ProdList
573
Advantage
86
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
ChemSampCo, Inc.
Tel
--
Fax
--
Email
sales@chemsampco.com
Country
United States
ProdList
3585
Advantage
60
Penta Manufacturing Company
Tel
--
Fax
--
Email
sales@pentamfg.com
Country
United States
ProdList
5076
Advantage
65
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
DuPont Specialty Colorants & Additives
Tel
--
Fax
--
Country
United States
ProdList
1186
Advantage
87
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
More
Less

View Lastest Price from 1,4-Butanediol manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
1,4-Butanediol 110-63-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-09-27
RongNa Biotechnology Co.,Ltd
Product
1,4-Butanediol 110-63-4
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20 Tons
Release date
2025-05-04
Guangdong Junhua Chemical Co., Ltd
Product
1,4-Butanediol 110-63-4
Price
US $150.00-19.00/kg
Min. Order
1kg
Purity
99％pure
Supply Ability
20 tons
Release date
2024-12-25

110-63-4, 1,4-ButanediolRelated Search:

2-Methyl-2,4-pentanediol DI(PROPYLENE GLYCOL) BUTYL ETHER CYCLOBUTANE 2-Butoxyethyl acetate Dipropylene glycol Diethylene glycol 2,3-Butanediol Ethylene glycol 2-Butoxyethanol Ethylene glycol diacetate 1-BUTENE PROPYLENE GLYCOL (+/-)-1,2-BUTANEDIOL,1,2-BUTANEDIOL 1,4-Butanediol, d,l-2,3-dibromo-,1,4-BUTANEDIOL, 2,3-DIBROMO-, (+,-)-,1,4-Butanediol, 2,3-dibromo-, (R*,R*)-(.+/-.)-,2,3-dibromo-,(+,-)-4-butanedio 1,4-Cyclohexanediol (S,S)-(+)-2,3-BUTANEDIOL,(S,S)-2,3-BUTANEDIOL 1,3-Butanediol 1,3-cyclopentanediol

  • 1,4-BUTYLENE GLYCOL
  • 1,4-BUTANEDIOL
  • 1,4-DIHYDROXYBUTANE
  • AKOS BBS-00004303
  • BDO
  • BUTANEDIOL, 1,4-
  • TETRAMETHYLENE GLYCOL
  • VERSALINK CURATIVE 1,4 BDO
  • BUTANE-1,4-DIOL
  • agrisynthb1d
  • butane,1,4-dihydroxy-
  • Butanediol
  • Butylene glycol
  • Dabco BDO
  • Diol 14B
  • diol14b
  • Sucol B
  • 1,4-BD
  • 1,4-Tetramethylene
  • 1,4-Tetramethylene glycol
  • 1,4-tetramethyleneglycol
  • 1,4-Butanediol,1,4-Butylene glycol, Tetramethylene glycol
  • 1,4-Butanediol, 99+% 1LT
  • 1,4-Butanediol, 99+% 2.5LT
  • 1,4-Butylene Glycol 1,4-Dihydroxybutane Tetramethylene Glycol
  • 1,4-Butanediol, water ≤500 ppM
  • 1,4-BUTANEDIOL FOR SYNTHESIS
  • 1,4-Butylene glycol (BDO)
  • 1,4-Butanediol ReagentPlus(R), 99%
  • 1,4-Butanediol Vetec(TM) reagent grade, 98%
  • 1,4-Butaandiol
  • Additive Screening Solution 04/Fluka kit no 78374
  • 1,4-Butylene glycol~Tetramethylene
  • 4-Butanediol
  • 1,4-Butanediol, 99%, water ≤500 ppm
  • sucolb
  • Tetramethylene 1,4-diol
  • tetramethylene1,4-diol
  • 1,4-dilhydroxybutane
  • 1,4-BUTANEDIOL AR
  • Butan-1, 4-diol
  • 1,4-Butanediol, 99% liquid
  • 1,4-Butylene glycol~Tetramethylene glycol
  • 1 4-BUTANEDIOL REAGENTPLUSTM >=99%
  • 1 4-BUTANEDIOL REAGENTPLUS 99%
  • 1,4-Butanediol 4 M Solution
  • 1,4-BUTANEDIOL, REAGENTPLUS, >=99%
  • 1,4-BUTANEDIOL, REAGENTPLUS, 99%
  • 1,4-BUTANEDIOL GC STANDARD
  • 1,4-Butanediol,98%
  • 1,4-Butanediol,Certified
  • 1,4-Butanediol(1,4-butyleneglycol)
  • 1,4-BUTANEDIOL (1,4-BG)
  • 1,4-Butanediol, 99+%
  • BUTANEDIOL, 1,4-(SG)
  • 1,4-Butandiol
  • 1,4-Butanediol (BDO)
  • 1,4-Butanediol liquid