3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Product Name
- 3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 62733-99-7
- Chemical Name
- 3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- SPECS AJ-333/25006091;Methyl 3-hydroxypicolinate;3-HYDROXYPICOLINIC ACID METHYL ESTER;Methyl-3-Hydroxypyridine-2-Carboxlate;METHYL 3-HYDROXYPYRIDINE-2-CARBOXYLATE;3-hydroxy-2-pyridinecarboxylicacidmethylester;3-Hydroxy-pyrdine-2-carboxylic acid methyl ester;3-Hydroxy-pyridin-2-carboxylic acid methyl ester;3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER;methyl 3-hydroxypyridine-2-carboxylate - [M28681]
- CBNumber
- CB4459158
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 62733-99-7.mol
3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Property
- Melting point:
- 75.0 to 79.0 °C
- Boiling point:
- 340.6±22.0 °C(Predicted)
- Density
- 1.287±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 4.45±0.10(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C7H7NO3/c1-11-7(10)6-5(9)3-2-4-8-6/h2-4,9H,1H3
- InChIKey
- MHKKUZDJUGIOBC-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC=CC=C1O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M2973
- Product name
- Methyl 3-Hydroxy-2-pyridinecarboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- M2973
- Product name
- Methyl 3-Hydroxy-2-pyridinecarboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $310
- Updated
- 2025/07/31
- Product number
- M323485
- Product name
- Methyl3-hydroxypicolinate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 455267
- Product name
- Methyl 3-hydroxypicolinate
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- CHM0023646
- Product name
- 3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1363.65
- Updated
- 2021/12/16
3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
67-56-1
874-24-8
62733-99-7
A suspension of methanol (150 mL, 0.5 M) of 3-hydroxy-2-pyridinecarboxylic acid (10 g, 72 mmol, 1 eq.) was slowly added dropwise to concentrated sulfuric acid (12 mL, 216 mmol, 3 eq.) at 0 °C. The reaction mixture was stirred under reflux conditions for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. Subsequently, the pH was adjusted to 8.5 with saturated aqueous NaHCO3 and solid NaHCO3. The aqueous layer was extracted with EtOAc, and the combined organic layers were washed with brine, dried over MgSO4, and concentrated under reduced pressure to afford methyl 3-hydroxy-2-pyridinecarboxylate as a white solid (10.9 g, 99%). Thin layer chromatography (TLC) showed Rf = 0.3 (petroleum ether/EtOAc 1:1, v/v). Melting point was 74°C. 1H NMR (300 MHz, CDCl3): δ (ppm) = 4.06 (s, 3H), 7.34 (dd, J = 3.9,8.4 Hz, 1H), 7.38 (dd, J = 1.5,8.4 Hz, 1H), 8.38 (dd, J = 1.5,3.9 Hz, 1H), 10.64 (s, 1H). 13C NMR (75 MHz, CDCl3): δ= 53.2,126.3,129.8,130.2,141.6,158.9,169.9. mass spectra (ESI+): m/z (%): 154 (100) [M + H]+.
References
[1] Journal of Controlled Release, 2018, vol. 290, p. 102 - 111
[2] Tetrahedron, 2011, vol. 67, # 11, p. 2118 - 2124
[3] Patent: WO2018/5662, 2018, A1. Location in patent: Paragraph 0290
[4] Patent: EP3255042, 2017, A2. Location in patent: Paragraph 0180; 0181
[5] Patent: WO2014/121418, 2014, A1. Location in patent: Page/Page column 44
3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER manufacturers
- Product
- 3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 62733-99-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- 3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 62733-99-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24
- Product
- Methyl 3-hydroxypicolinate 62733-99-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 MT
- Release date
- 2020-07-28