ChemicalBook > CAS DataBase List > 2-Bromo-1,4-dichlorobenzene

2-Bromo-1,4-dichlorobenzene

Product Name: 2-Bromo-1,4-dichlorobenzene
CAS No.: 1435-50-3
Chemical Name: 2-Bromo-1,4-dichlorobenzene
Synonyms: 2-Bromo-1,4-dichloro;2,5-DICHLOROBROMOBENZENE;2,5-Dichlorobeomobenzene;2,5-Dichlorophenyl bromide;2-BROMO-1,4-DICHLOROBENZENE;1-BROMO-2,5-DICHLOROBENZENE;Benzene, 1-bromo-2,5-dichloro-;Benzene, 2-bromo-1,4-dichloro-;1-Bromo-2,5-dichlorobenzene,99%;1-Bromo-2,5-dichlorobenzene >
CBNumber: CB4473288
Molecular Formula: C6H3BrCl2
Formula Weight: 225.9
MOL File: 1435-50-3.mol

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2-Bromo-1,4-dichlorobenzene Property

Melting point:: 32-36 °C(lit.)
Boiling point:: 118-120°C 20mm
Density: 1.6351 (rough estimate)
refractive index: 1.5700 (estimate)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
form: powder to lump to clear liquid
color: White or Colorless to Light orange to Yellow
Water Solubility: insoluble
BRN: 1934815
InChI: InChI=1S/C6H3BrCl2/c7-5-3-4(8)1-2-6(5)9/h1-3H
InChIKey: OVXVQBCRONSPDC-UHFFFAOYSA-N
SMILES: C1(Cl)=CC=C(Cl)C=C1Br
CAS DataBase Reference: 1435-50-3(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, 2-bromo-1,4-dichloro-(1435-50-3)
EPA Substance Registry System: Benzene, 2-bromo-1,4-dichloro- (1435-50-3)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38
Safety Statements: 26-36-28A
WGK Germany: 3
Hazard Note: Toxic
HazardClass: IRRITANT
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B0981
Product name: 1-Bromo-2,5-dichlorobenzene
Packaging: 5G
Price: $17
Updated: 2025/07/31

TCI Chemical

Product number: B0981
Product name: 1-Bromo-2,5-dichlorobenzene
Packaging: 25G
Price: $86
Updated: 2025/07/31

TRC

Product number: B683390
Product name: 2-Bromo-1,4-dichlorobenzene
Packaging: 10g
Price: $120
Updated: 2021/12/16

Matrix Scientific

Product number: 001273
Product name: 1-Bromo-2,5-dichlorobenzene
Purity: 98%
Packaging: 100g
Price: $129
Updated: 2021/12/16

Apolloscientific

Product number: OR1563
Product name: 2,5-Dichlorobromobenzene
Packaging: 100g
Price: $132
Updated: 2021/12/16

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2-Bromo-1,4-dichlorobenzene Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

2-Bromo-1,4-dichlorobenzene is a reactant used in the synthesis of C-13 and C-14-labeled versions of the investigational proteasome inhibitor MLN9708.

Synthesis

106-46-7

1435-50-3

4571-24-8

General procedure for the synthesis of 1-bromo-2,5-dichlorobenzene and 1,4-dibromo-2,5-dichlorobenzene from 1,4-dichlorobenzene: 147.0 g (1.00 mol) of 1,4-dichlorobenzene was accurately weighed in a reactor, and 515 g of carbon tetrachloride was added as a solvent to make it completely soluble. Subsequently, 7.35 g of anhydrous aluminum chloride was added to the solution as a catalyst and after stirring for 15 minutes, the temperature of the reaction system was raised to 35°C. At this temperature, dropwise addition of 105.6 g (0.66 mol) of bromine was initiated at a constant dropwise acceleration, and the dropwise process lasted for 9 hours to complete. Upon completion of the reaction, 200.0 g of 5% mass fraction sodium bisulfite solution was added to the reaction mixture until the color of the mixture changed to colorless. After standing and layering, the organic phase was separated and the resulting carbon tetrachloride layer was concentrated. Eventually, 73.0 g (0.50 mol) of unreacted 1,4-dichlorobenzene, 111.5 g (0.48 mol) of 1-bromo-2,5-dichlorobenzene and 7.1 g (0.02 mol) of 1,4-dibromo-2,5-dichlorobenzene were obtained by distillation.

References

[1] Green Chemistry, 2012, vol. 14, # 9, p. 2380 - 2383
[2] Patent: CN105801334, 2016, A. Location in patent: Paragraph 0066

2-Bromo-1,4-dichlorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

2,5-Dichlorophenylboronic acid

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View Lastest Price from 2-Bromo-1,4-dichlorobenzene manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Bromo-1,4-dichlorobenzene 1435-50-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 10000kg
Release date: 2024-08-09

Henan Fengda Chemical Co., Ltd

Product: 2-Bromo-1,4-dichlorobenzene 1435-50-3
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

Career Henan Chemical Co

Product: 2-Bromo-1,4-dichlorobenzene 1435-50-3
Price: US $5.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1ton
Release date: 2019-08-05

1435-50-3, 2-Bromo-1,4-dichlorobenzeneRelated Search:

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2-BROMO-1,4-DICHLOROBENZENE

2,5-DICHLOROBROMOBENZENE

1-BROMO-2,5-DICHLOROBENZENE

Benzene, 1-bromo-2,5-dichloro-

1-BroMo-2,5-dichlorobenzene[2,5-DichlorobroMobenzene]

2,5-Dichlorobeomobenzene

2,5-Dichlorophenyl bromide

1-Bromo-2,5-dichlorobenzene,99%

2-Bromo-1,4-dichlorobenzene, 98+%

2-Bromo-1,4-dichloro

1-Bromo-2,5-dichlorobenzene &gt

Benzene, 2-bromo-1,4-dichloro-

2-Bromo-1,4-dichlorobenzene ISO 9001：2015 REACH

2,5-Dichlorobromobenzene, 98%min

1435-50-3

C4H3BrCl2

C18H3Br

BrC6H3Cl2

ARYL HALIDE

Halogenated Hydrocarbons

Organic Building Blocks

Aryl

Building Blocks

Bromine Compounds

Chlorine Compounds