BT-13

Product Name: BT-13
CAS No.: 924537-98-4
Chemical Name: BT-13
Synonyms: 319H6;BT-13;BT 13 NEW;BT-13, 10 mM in DMSO;BT-13 (RET agonist BT13);RET,Inhibitor,BT-13,inhibit,BT13,BT 13;N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-4-methoxybenzenesulfonamide;Benzenesulfonamide, N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]-4-methoxy-
CBNumber: CB44840103
Molecular Formula: C23H27F4N3O4S
Formula Weight: 517.54
MOL File: 924537-98-4.mol

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BT-13 Property

Boiling point:: 637.0±65.0 °C(Predicted)
Density: 1.326±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 25 mg/mL (48.31 mM)
pka: 0.42±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0086405
Product name: BT-13
Purity: >99.0%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BB168381
Product name: BT 13 NEW
Packaging: 10mg
Price: $185
Updated: 2021/12/16

ChemScene

Product number: CS-0086405
Product name: BT-13
Purity: >99.0%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BB168381
Product name: BT 13 NEW
Packaging: 50mg
Price: $647.5
Updated: 2021/12/16

ChemScene

Product number: CS-0086405
Product name: BT-13
Purity: >99.0%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

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BT-13 Chemical Properties,Usage,Production

Biological Activity

BT-13 is a potent, selective agonist of the glial cell-derived neurotrophic factor (GDNF) receptor RET (acts independently of GDNF ligands), promotes sensory neuron neurite outgrowth in vitro, and alleviates neuropathy in rats happened.

in vitro

BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET.

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in vivo

BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy.

Animal Model:	Rats induced by ligation of left L5 and L6 spinal nerves.
Dosage:	5-25 mg/kg, dissolved in sesame oil containing 5% DMSO.
Administration:	Subcutaneous injections on post-surgical days 1, 3, 5, 8, 10, and 12.
Result:	20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.

target

GDNF receptor RET.

BT-13 Preparation Products And Raw materials

Raw materials

Preparation Products

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BT-13 Suppliers

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924537-98-4, BT-13Related Search:

319H6

BT-13 (RET agonist BT13)

BT 13 NEW

Benzenesulfonamide, N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]-4-methoxy-

BT-13

RET,Inhibitor,BT-13,inhibit,BT13,BT 13

N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-4-methoxybenzenesulfonamide

BT-13, 10 mM in DMSO

924537-98-4

C23H27F4N3O4S