ChemicalBook > CAS DataBase List > BT-13
BT-13
- Product Name
- BT-13
- CAS No.
- 924537-98-4
- Chemical Name
- BT-13
- Synonyms
- 319H6;BT-13;BT 13 NEW;BT-13, 10 mM in DMSO;BT-13 (RET agonist BT13);RET,Inhibitor,BT-13,inhibit,BT13,BT 13;N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-4-methoxybenzenesulfonamide;Benzenesulfonamide, N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]-4-methoxy-
- CBNumber
- CB44840103
- Molecular Formula
- C23H27F4N3O4S
- Formula Weight
- 517.54
- MOL File
- 924537-98-4.mol
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BT-13 Property
- Boiling point:
- 637.0±65.0 °C(Predicted)
- Density
- 1.326±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 25 mg/mL (48.31 mM)
- pka
- 0.42±0.20(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0086405
- Product name
- BT-13
- Purity
- >99.0%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- BB168381
- Product name
- BT 13 NEW
- Packaging
- 10mg
- Price
- $185
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0086405
- Product name
- BT-13
- Purity
- >99.0%
- Packaging
- 10mg
- Price
- $280
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- BB168381
- Product name
- BT 13 NEW
- Packaging
- 50mg
- Price
- $647.5
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0086405
- Product name
- BT-13
- Purity
- >99.0%
- Packaging
- 50mg
- Price
- $850
- Updated
- 2021/12/16
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BT-13 Chemical Properties,Usage,Production
Biological Activity
BT-13 is a potent, selective agonist of the glial cell-derived neurotrophic factor (GDNF) receptor RET (acts independently of GDNF ligands), promotes sensory neuron neurite outgrowth in vitro, and alleviates neuropathy in rats happened.
in vitro
BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET.
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in vivo
BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy.
| Animal Model: | Rats induced by ligation of left L5 and L6 spinal nerves. |
| Dosage: | 5-25 mg/kg, dissolved in sesame oil containing 5% DMSO. |
| Administration: | Subcutaneous injections on post-surgical days 1, 3, 5, 8, 10, and 12. |
| Result: | 20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia. |
target
GDNF receptor RET.
BT-13 Preparation Products And Raw materials
Raw materials
Preparation Products
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BT-13 Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58