ChemicalBook > CAS DataBase List > Octamethylcyclotetrasiloxane

Octamethylcyclotetrasiloxane

Product Name
Octamethylcyclotetrasiloxane
CAS No.
556-67-2
Chemical Name
Octamethylcyclotetrasiloxane
Synonyms
D4;OMCTS;Cyclotetrasiloxane,octamethyl-;Cyclic tetramer;unioncarbide7207;OCTAMETHYLTETRASILOXANE;Oktamethylcyklotetrasiloxan;Octamethylcyclotetrasiloxane,98%;2-Benzimidazolecarbamic Acid Methyl Ester-d4;2,2,4,4,6,6,8,8-Octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
CBNumber
CB4490223
Molecular Formula
C8H24O4Si4
Formula Weight
296.62
MOL File
556-67-2.mol
More
Less

Octamethylcyclotetrasiloxane Property

Melting point:
17-18 °C (lit.)
Boiling point:
175-176 °C (lit.)
Density 
0.956 g/mL at 25 °C (lit.)
vapor density 
1 (vs air)
vapor pressure 
1.32hPa at 25℃
refractive index 
n20/D 1.396(lit.)
Flash point:
140 °F
storage temp. 
Store below +30°C.
solubility 
<0.001g/l Hydrolysis
form 
liquid
color 
colorless
Specific Gravity
0.956
explosive limit
0.4-11.7%(V)
biological source
rabbit
Water Solubility 
INSOLUBLE
Sensitive 
Moisture Sensitive
Merck 
14,6747
BRN 
1787074
Dielectric constant
2.4（20℃）
InChIKey
HMMGMWAXVFQUOA-UHFFFAOYSA-N
LogP
6.98 at 21.7℃
CAS DataBase Reference
556-67-2(CAS DataBase Reference)
NIST Chemistry Reference
Cyclotetrasiloxane, octamethyl-(556-67-2)
EPA Substance Registry System
Octamethylcyclotetrasiloxane (556-67-2)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
53-62-10
Safety Statements 
36/37-46-51-61
RIDADR 
UN 1993 3/PG 3
WGK Germany 
1
RTECS 
GZ4397000
Autoignition Temperature
400°C
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29319090
Hazardous Substances Data
556-67-2(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 1540mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14750
Product name
Octamethylcyclotetrasiloxane
Purity
for synthesis
Packaging
25ML
Price
$48.6
Updated
2025/07/31
Sigma-Aldrich
Product number
SAB4502621
Product name
Anti-REQU antibody produced in rabbit
Purity
affinity isolated antibody
Packaging
100 μg
Price
$522
Updated
2025/07/31
Sigma-Aldrich
Product number
8.14750
Product name
Octamethylcyclotetrasiloxane
Purity
for synthesis
Packaging
100ML
Price
$141
Updated
2025/07/31
Sigma-Aldrich
Product number
8.14750
Product name
Octamethylcyclotetrasiloxane
Purity
for synthesis
Packaging
250ML
Price
$227
Updated
2025/07/31
Sigma-Aldrich
Product number
235695
Product name
Octamethylcyclotetrasiloxane
Purity
98%
Packaging
25g
Price
$62.9
Updated
2025/07/31
More
Less

Octamethylcyclotetrasiloxane Chemical Properties,Usage,Production

Chemical Properties

Octamethylcyclotetrasiloxane is also known as D4. It is an odorless, colorless non-oily silicone fluid which has C8H24O4Si4 as chemical formula. It is a cyclic organic silicon substance which can be used as monomer in the production of silicone polymers such as rubber, resins and greases.

Uses

Octamethylcyclotetrasiloxane is used as a monomer in the production of silicone polymers and as an intermediate in the production of other organosilicon substances.Further it finds its application in electronics, textiles, personal care products and household care products.
Polydimethylsiloxane by the Polymerization of Octamethylcyclotetrasiloxane: To a resin flask equipped with a thermometer, stirrer, and reflux eondenser is added 1000 gm of octamethylcyclotetrasiloxane. The siloxane is heated to 165°C, and then 0.14gm of a potassium hydroxide-isopropanol complex (neutral equivalent = 193.5) is added to give a Si : Κ ratio of 4470:1. In 25 min the stirrer begins to stall, and the polymer is now heated for 3(1/2) hr at 150°C to complete polymerization. The resulting polymer has an intrinsic viscosity of 1.5 dl/gm corresponding to a molecular weight of 804,600.

Definition

ChEBI: Octamethylcyclotetrasiloxane is a cyclosiloxane that is the octamethyl derivative of cyclotetrasiloxane. It is an organosilicon compound and a cyclosiloxane. It derives from a hydride of a cyclotetrasiloxane.

Preparation

Commercially Octamethylcyclotetrasiloxane is produced from dimethyldichlorosilane. Dimethyldichlorosilane is added dropwise to water, the temperature is maintained at 30-40°C, stratified, the acid water is released, the oily material is hydrolyzed with sodium hydroxide solution, the hydrolysate and 0.5%-2% potassium hydroxide are added to the cracking kettle and cracked at 120-140°C and 99.8 kPa vacuum. The cracked material is fractionated and the fraction is collected at 173-176°C to obtain octamethylcyclotetraoxysilane.

General Description

Octamethylcyclotetrasiloxane (D4) is a volatile methylsiloxane (VMS) with a relatively low molecular weight. This silicone fluid has a silicon-oxygen bond in a cyclic arrangement and methyl groups are attached to the silicon atom. D4 can be used in the manufacture of silicone based polymers for use in medical devices and personal care products.

Health Hazard

Octamethylcyclotetrasiloxane (D4) can interfere with the body’s hormones. In animals, it can affect the reproductive system.
D4 is classified as a category 1 endocrine disruptor by the European Commission. A 2018 study commissioned by the Danish EPA identified D4 as an endocrine disruptor. The Global Harmonized System Label Requirements classified D4 as suspected to produce reproductive toxicity. D4 was added to the Toxic Substances Control Act work plan due to reproductive toxicity, moderate environmental persistence, and high bioaccumulation potential.
Adverse reproductive effects including estrogenic effects have been observed in rodents. The European Chemicals Agency characterized D4 as a persistent, bioaccumulative, and toxic chemical, and designated D4 as a Substance of Very High Concern.

Flammability and Explosibility

Flammable

Safety Profile

A skin irritant. When heated todecomposition it emits acrid smoke and irritating vapors.

Purification Methods

The solid exists in two forms, m 16.30o and 17.65o. Dry it over CaH2 and distil it. Further fractionation can be effected by repeated partial freezing and discarding the liquid phase. [Osthoff & Grubb J Am Chem Soc 76 399 1954, Hoffman J Am Chem Soc 75 6313 1953, Beilstein 4 IV 4125.]

Toxics Screening Level

The initial threshold screening level (ITSL) for octamethylcyclotetrasiloxane is 75 μg/m3 based on an annual averaging time.

Octamethylcyclotetrasiloxane Preparation Products And Raw materials

Raw materials

Hydrolyzate Dichlorodimethylsilane

Preparation Products

Dimethicone Organosilicon water-proofing agent Hydroxy silicone oil emulsion Dimethoxymethylphenylsilane Silicone rubber,high temperature-vulcanized mixing Poly(dimethylsiloxane) Polydimethylsiloxane, dihydroxy terminated Silicone rubber,methyl RTV 107 silicone softener RS Amino-modified silicone oil Silicone oil polyether modified Silicone oil
More
Less

Octamethylcyclotetrasiloxane Suppliers

Americas 1 Australia 2 Belgium 3 Bulgaria 1 Canada 4 China 376 Europe 1 France 2 Germany 10 India 12 Italy 1 Japan 6 New Zealand 1 Poland 1 Russia 1 Singapore 1 Spain 1 Switzerland 2 United Kingdom 13 United States 53 Global 492
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Eastar Chemical Corp
Tel
+86-024-25362369-8022 +8613998281317
Email
angelameng@chinaeastar.com
Country
United States
ProdList
376
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
Aston Chemical
Tel
13000000000
Email
sales@astonchem.com
Country
United States
ProdList
1634
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Silar Laboratories
Tel
--
Fax
--
Email
info@silar.com
Country
United States
ProdList
335
Advantage
50
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Milliken & Company
Tel
--
Fax
--
Country
United States
ProdList
50
Advantage
58
Sarchem Laboratories, Inc.
Tel
--
Fax
--
Email
info@sarchemlabs.com
Country
United States
ProdList
736
Advantage
58
2A Biotech USA
Tel
--
Fax
--
Email
info@2abiotech.com
Country
United States
ProdList
1785
Advantage
58
MP Biomedicals, LLC. (Division of Valiant FC Co., Ltd.)
Tel
--
Fax
--
Email
serv@mpbio.com
Country
United States
ProdList
1854
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
vulcanchem
Tel
--
Fax
--
Email
info@vulcanchem.com
Country
United States
ProdList
268
Advantage
58
Parchem Fine & Specialty Chemicals
Tel
--
Fax
--
Email
info@parchem.com
Country
United States
ProdList
1031
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
SiVance LLC (subsidiary of Milliken)
Tel
--
Fax
--
Country
United States
ProdList
21
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Chemphtec Corporation
Tel
--
Fax
--
Email
fo@chemphtec.com
Country
United States
ProdList
2181
Advantage
58
Moravek, Inc.
Tel
--
Fax
--
Email
info@moravek.com
Country
United States
ProdList
279
Advantage
58
Beantown Chemical Corporation
Tel
--
Fax
--
Country
United States
ProdList
396
Advantage
58
Chem-Impex International, Inc. (CII)
Tel
--
Fax
--
Email
Customer@chemimpex.com
Country
United States
ProdList
893
Advantage
58
Wilshire Technologies, Inc.
Tel
--
Fax
--
Email
info@wilshiretechnologies.com
Country
United States
ProdList
893
Advantage
58
AA Blocks LLC
Tel
--
Fax
--
Email
s@aablocks.com
Country
United States
ProdList
536
Advantage
58
Crescent Chemical Company
Tel
--
Fax
--
Email
fran@creschem.com
Country
United States
ProdList
1441
Advantage
58
Advanced Polymer, Inc.
Tel
--
Fax
--
Email
aerguiza@advpolymer.com
Country
United States
ProdList
9
Advantage
58
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Norman, Fox & Co.
Tel
--
Fax
--
Email
info@norfoxchem.com
Country
United States
ProdList
30
Advantage
58
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
TCI America, Inc. (part of Tokyo Chemical Industry)
Tel
--
Fax
--
Email
Angelina.Crew@tcichemicals.com
Country
United States
ProdList
2053
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Strem Chemicals, Inc.
Tel
--
Fax
--
Email
info@strem.com
Country
United States
ProdList
4910
Advantage
86
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Cambridge Isotope Laboratories, Inc.
Tel
--
Fax
--
Email
cilsales@isotope.com
Country
United States
ProdList
6598
Advantage
79
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Gelest, Inc.
Tel
--
Fax
--
Email
info@gelest.com
Country
United States
ProdList
3973
Advantage
84
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
More
Less

View Lastest Price from Octamethylcyclotetrasiloxane manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Octamethylcyclotetrasiloxane 556-67-2
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-21
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Octamethylcyclotetrasiloxane 556-67-2
Price
US $60.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-10
Hebei Yiduo Import and Export Co., Ltd.
Product
Octamethylcyclotetrasiloxane 556-67-2
Price
US $100.00-80.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000000
Release date
2025-03-21

556-67-2, OctamethylcyclotetrasiloxaneRelated Search:

1,1,3,3,5,5-hexamethyl-1,3,5-trisilacyclohexane Hexamethylcyclotrisiloxane Octamethylcyclotetrasilazane POLYDIMETHYLSILOXANE Dimethicone Octamethyltrisiloxane Hexamethyldisiloxane Octaphenylcyclotetrasiloxane Silicone oilⅤ Poly(dimethylsiloxane) 1,1,3,3-Tetramethyldisiloxane DODECAMETHYLCYCLOHEXASILOXANE Silicone oil PolydimettIylsiloxane 1,3,5,7-TETRAKIS(3,3,3-TRIFLUOROPROPYL)1,3,5,7-TETRAMETHYLCYCLOSILOXANES 2,4,6,8-Tetravinyl-2,4,6,8-tetramethylcyclotetrasiloxane 1,1,3,3-Tetramethyltetraphenylcyclotetrasiloxane heptamethylphenylcyclotetrasiloxane

  • JACS-556-67-2
  • uc7207
  • unioncarbide7207
  • vs7207
  • Octamethylcyclotetrasiloxane,98%
  • 1H-Benzimidazol-2-yl-carbamic Acid Methyl Ester-d4
  • 2-Benzimidazolecarbamic Acid Methyl Ester-d4
  • BAS-3460-d4
  • BAS-67054-d4
  • BCM-d4
  • Octamethylcyclotetra
  • OctaMethylcyclotetrasiloxane, 98% 25GR
  • OCLaMethylcyclotetrasiloxane
  • OCTAMETHYLCYCLOTETRASILOXANE FOR SYNTHES
  • Cyclotetrasiloxane,octaMethyl- (8CI,9CI)
  • D4 Cyclomethicone
  • Anti-REQU antibody produced in rabbit
  • Apoptosis response zinc finger protein
  • DPF2
  • OCTAMETHYLCYCLOTETRASILOXANE
  • OCTAMETHYLTETRASILOXANE
  • VOLASIL(TM) 244
  • 2,2,4,4,6,6,8,8-Octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
  • CO9810
  • cyclicdimethylsiloxanetetramer
  • Cyclotetrasiloxane,octamethyl-
  • kf994
  • NUC Silicone VS 7207
  • nucsiliconevs7207
  • O9810
  • REQ
  • zinc and double PHD fingers family 2
  • STRAY LIGHT FILTER(260NM) RSPEC00371
  • Dimethylsiloxane cyclic tetramer≥ 97% (assay)
  • D4 Octamethylcyclotetrasiloxane
  • Cyclomethicone 4
  • DIMETHYLSILOXANE CYCLIC TETRAMER
  • D4
  • otetrasiL
  • Dimethylsiloxane cyclic tetramer (assay)
  • N-ACETYL-5-METHOXYTRYPTAMINE-&alpha
  • Cyclic tetramer
  • OMCTS
  • D-Glucose-4,5,6,6&rsquo
  • Octamethylcyclotetraoxysilane
  • octamethyl-cyclotetrasiloxan
  • octamethylcyclotetrasiloxane(volasil244)
  • Oktamethylcyklotetrasiloxan
  • sf1173
  • siliconesf1173
  • tetracyclosiloxane,octamethyl-
  • Octamethyl-tetrasil-tetroxan
  • Octamethylcyclotetrasiloxane D4
  • BMC-d4
  • Carbendazole-d4
  • MBC-d4
  • OCTAMETHYLCYCLOTETARSILOXANE
  • OCTAMETHYLTETRACYCLOSILOXANE