IC86621

Product Name: IC86621
CAS No.: 404009-40-1
Chemical Name: IC86621
Synonyms: IC 86621 (IC86621);IC 86621, 10 mM in DMSO;IC86621 CAS#: 404009-40-1;1-(2-hydroxy-4-Morpholinophenyl)ethanone;1-(2-Hydroxy-4-morpholinophenyl)ethan-1-one;Ethanone, 1-[2-hydroxy-4-(4-morpholinyl)phenyl]-;DNA-PK Inhibitor III - CAS 404009-40-1 - Calbiochem;1-(2-Hydroxy-4-morpholinophenyl)ethan-1-one , IC 86621;ATP,Buchwald-Hartwig amination,Inhibitor,IC-86621,IC86621,IC 86621,DSB,antitumor,inhibit,Apoptosis,Fries rearrangement,DNA-dependent protein kinase,DNA-PK
CBNumber: CB4503635
Molecular Formula: C12H15NO3
Formula Weight: 221.25
MOL File: 404009-40-1.mol

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IC86621 Property

Melting point:: 98-100.3 °C
Boiling point:: 425.5±45.0 °C(Predicted)
Density: 1.210±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 15 mg/mL
pka: 10.47±0.10(Predicted)
form: solid
color: off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 260962
Product name: DNA-PK Inhibitor III
Packaging: 1mg
Price: $154
Updated: 2023/01/07

TRC

Product number: H852750
Product name: 1-(2-Hydroxy-4-morpholinophenyl)ethanone
Packaging: 10mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0073228
Product name: 1-(2-HYDROXY-4-MORPHOLINOPHENYL)ETHANONE
Purity: 95.00%
Packaging: 100MG
Price: $824.19
Updated: 2021/12/16

AK Scientific

Product number: 4512AH
Product name: 1-(2-Hydroxy-4-morpholinophenyl)ethanone
Packaging: 250mg
Price: $428
Updated: 2021/12/16

Chemenu

Product number: CM314918
Product name: 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone
Purity: 95%
Packaging: 1g
Price: $571
Updated: 2021/12/16

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IC86621 Chemical Properties,Usage,Production

Definition

ChEBI: 1-[2-hydroxy-4-(4-morpholinyl)phenyl]ethanone is an aromatic ketone.

General Description

A cell-permeable aryl-morpholino compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC₅₀ = 120 nM) and PI 3-Kinase catalytic subunit p110β (IC₅₀ = 135 nM). It inhibits DNA-PK-mediated cellular DNA DSB (double strand break) repair (EC₅₀ = 68 μM) and enhances DSB-induced antitumor activity both in vitro and in vivo, while exhibiting no cytotoxic effects (up to 50 μM) in the absence of DSBs. It inhibits PI 3-K p110α, p110γ, and p110δ only at much higher concentrations (IC₅₀ = 1.4, 0.88, and 1.0 μM, respectively) and exhibits no effect against a panel of several other kinases, including, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12, even at concentrations as high as 100 μM.

Biochem/physiol Actions

Cell permeable: yes

IC86621 Preparation Products And Raw materials

Raw materials

Preparation Products

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IC86621 Suppliers

China 22 India 1 Switzerland 1 United States 5 Global 29

Sigma-Aldrich

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404009-40-1, IC86621Related Search:

DNA-PK Inhibitor III - CAS 404009-40-1 - Calbiochem

IC 86621 (IC86621)

1-(2-hydroxy-4-Morpholinophenyl)ethanone

IC86621 CAS#: 404009-40-1

Ethanone, 1-[2-hydroxy-4-(4-morpholinyl)phenyl]-

1-(2-Hydroxy-4-morpholinophenyl)ethan-1-one

ATP,Buchwald-Hartwig amination,Inhibitor,IC-86621,IC86621,IC 86621,DSB,antitumor,inhibit,Apoptosis,Fries rearrangement,DNA-dependent protein kinase,DNA-PK

1-(2-Hydroxy-4-morpholinophenyl)ethan-1-one , IC 86621

IC 86621, 10 mM in DMSO

404009-40-1

1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone

IC86621