4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-

Product Name: 4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-
CAS No.: 1361227-90-8
Chemical Name: 4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-
Synonyms: JH-RE-06;JH-RE-06 ，S8850;JH-RE-06, 10 mM in DMSO;JH RE 06,DNA/RNA Synthesis,inhibit,Inhibitor,JHRE06;8-Chloro-2-((2,4-dichlorophenyl)amino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one;4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-
CBNumber: CB45486742
Molecular Formula: C20H16Cl3N3O4
Formula Weight: 468.72
MOL File: 1361227-90-8.mol

More

Less

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Property

Boiling point:: 586.9±50.0 °C(Predicted)
Density: 1.503±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 5 mg/mL (10.67 mM)
form: Solid
pka: -3.78±0.70(Predicted)
color: White to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2993
Product name: JH-RE-06
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $120.65
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2993
Product name: JH-RE-06
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $489
Updated: 2025/07/31

ChemScene

Product number: CS-0099826
Product name: JH-RE-06
Purity: 99.87%
Packaging: 5mg
Price: $570
Updated: 2021/12/16

ChemScene

Product number: CS-0099826
Product name: JH-RE-06
Purity: 99.87%
Packaging: 10mg
Price: $965
Updated: 2021/12/16

Axon Medchem

Product number: Axon3002
Product name: JH-RE-06
Purity: 99%
Packaging: 5mg
Price: $159.5
Updated: 2021/12/16

More

Less

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Chemical Properties,Usage,Production

Uses

JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Ki=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy[1].

Biological Activity

JH-RE-06 is a potent and selective inhibitor of REV1-REV7 interaction th at induces REV1 dimerization blocking the REV1-REV7 interaction and POL ϲ recruitment. JH-RE-06 potently inhibits translesion synthesis (TLS) and augments cisplatin effectiveness in cultured human and mouse cell lines. It improves effectiveness of cisplatin in A375 tumor xenograft mouse model.

References

[1] Wojtaszek JL, et al. A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. Cell. 2019;178(1):152-159.e11. DOI:10.1016/j.cell.2019.05.028

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Suppliers

China 31 United States 3 Global 34

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2390
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5167
Advantage: 58

Wuhan Dingtong Pharmaceutical Co., Ltd

Tel: 027-027-59207795 18327179646
Fax: 027-59207795
Email: 18327179646@163.com
Country: China
ProdList: 1986
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62220
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2742
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-025-66113011 18626450290
Email: cb5@aikonchem.com
Country: China
ProdList: 10358
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Henan Mengtai Pharmaceutical Technology Co., Ltd

Tel: 176345344 7 17634854698
Email: 1959525201@qq.com
Country: China
ProdList: 10000
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

Shanghai Weijiahe Biotechnology Co., Ltd

Tel: 17502176150
Email: 861873257@qq.com
Country: China
ProdList: 1654
Advantage: 58

Guangzhou Yiran Biotechnology Co., Ltd.

Tel: 15571990006
Country: CHINA
ProdList: 141
Advantage: 58

Guangzhou Weisheng Biotechnology Co., Ltd.

Tel: 17765667235
Country: CHINA
ProdList: 129
Advantage: 58

Guangzhou Kegou Biotechnology Co., Ltd.

Tel: 18689410811
Country: CHINA
ProdList: 178
Advantage: 58

Guangzhou Haotian Biotechnology Co., Ltd.

Tel: 15571990006
Country: CHINA
ProdList: 122
Advantage: 58

Guangzhou Jingyan Biotechnology Co., Ltd.

Tel: 13822277471
Country: CHINA
ProdList: 187
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

1361227-90-8, 4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-Related Search:

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-

JH-RE-06

JH RE 06,DNA/RNA Synthesis,inhibit,Inhibitor,JHRE06

8-Chloro-2-((2,4-dichlorophenyl)amino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one

JH-RE-06, 10 mM in DMSO

JH-RE-06 ，S8850

1361227-90-8

C20H16Cl3N3O4