BO-264

Product Name: BO-264
CAS No.: 2408648-20-2
Chemical Name: BO-264
Synonyms: BO-264;BO-264, 10 mM in DMSO;3-(4-Methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine;3-(4-Methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine;4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-;inhibit,cytotoxicity,antitumor,Fibroblast growth factor receptor,BO-264,Apoptosis,Inhibitor,TACC3,spindle,abnormalities,FGFR,ERK1/2,BO 264,DNA,phosphorylation,FGFR3-TACC3,mitotic,damage,anti-proliferative,BO264
CBNumber: CB46199294
Molecular Formula: C18H19N5O3
Formula Weight: 353.38
MOL File: 2408648-20-2.mol

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BO-264 Property

Boiling point:: 627.9±65.0 °C(Predicted)
Density: 1.306±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
pka: 6.69±0.10(Predicted)
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0116466
Product name: BO-264
Purity: 99.63%
Packaging: 10mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-0116466
Product name: BO-264
Purity: 99.63%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0116466
Product name: BO-264
Purity: 99.63%
Packaging: 100mg
Price: $720
Updated: 2021/12/16

ChemScene

Product number: CS-0116466
Product name: BO-264
Purity: 99.63%
Packaging: 250mg
Price: $1300
Updated: 2021/12/16

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BO-264 Chemical Properties,Usage,Production

Description

BO-264 (2408648-20-2) is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity.1 TACC3 is frequently upregulated in a broad range of cancers. BO-264 displayed significant anticancer activity in greater than 90% of cell lines in the NCI-60 human cancer cell line panel. Active in vivo in mice injected with JIMT-1 and EMT6 breast cancer cells as well as mouse colon cancer xenografts HCT-116 and CT-26.

References

[1] nan

BO-264 Preparation Products And Raw materials

Raw materials

Preparation Products

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BO-264 Suppliers

China 59 United States 7 Global 66

BOC Sciences

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2408648-20-2, BO-264Related Search:

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BO-264

4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-

3-(4-Methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine

inhibit,cytotoxicity,antitumor,Fibroblast growth factor receptor,BO-264,Apoptosis,Inhibitor,TACC3,spindle,abnormalities,FGFR,ERK1/2,BO 264,DNA,phosphorylation,FGFR3-TACC3,mitotic,damage,anti-proliferative,BO264

BO-264, 10 mM in DMSO

3-(4-Methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine

2408648-20-2