4-CHLORO-3-IODO (1H)INDAZOLE

Product Name: 4-CHLORO-3-IODO (1H)INDAZOLE
CAS No.: 518990-33-5
Chemical Name: 4-CHLORO-3-IODO (1H)INDAZOLE
Synonyms: SKL525;4-CHLORO-3-IODOINDAZOLE;4-CHLORO-3-IODO (1H)INDAZOLE;1H-Indazole, 4-chloro-3-iodo-;4-chloro-3-iodo-1H-indazole(SALTDATA: FREE)
CBNumber: CB4666729
Molecular Formula: C7H4ClIN2
Formula Weight: 278.48
MOL File: 518990-33-5.mol

More

Less

4-CHLORO-3-IODO (1H)INDAZOLE Property

Melting point:: ca 223-224℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
Appearance: Off-white to light brown Solid
Sensitive: Light Sensitive

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TRC

Product number: C368605
Product name: 4-Chloro-3-iodo-1H-indazole
Packaging: 1g
Price: $745
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC152540
Product name: 4-Chloro-3-iodo-indazole
Packaging: 25mg
Price: $51
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC152540
Product name: 4-Chloro-3-iodo-indazole
Packaging: 100mg
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: Y9303
Product name: 4-Chloro-3-iodo-1H-indazole
Packaging: 5g
Price: $658
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0142815
Product name: 4-CHLORO-3-IODO(1H)INDAZOLE
Purity: 95.00%
Packaging: 1G
Price: $1386
Updated: 2021/12/16

More

Less

4-CHLORO-3-IODO (1H)INDAZOLE Chemical Properties,Usage,Production

Uses

4-?Chloro-?3-?iodo-1H-?indazole is a general reagent used in the synthesis of inhibitors of mitotic kinase TTK for cancer treatment.

Synthesis

13096-96-3

518990-33-5

General procedure for the synthesis of 4-chloro-3-iodo-1H-indazole from 4-chloro-1H-indazole: To a solution of 4-chloro-1H-indazole (1.7 g, 11.2 mmol, 1.0 equiv) in N,N-dimethylformamide (DMF, 20 mL) was added potassium hydroxide (KOH, 1.25 g, 22.4 mmol, 2.0 equiv). The reaction mixture was stirred at room temperature for 30 minutes. Subsequently, iodine (I2, 5.64 g, 22.4 mmol, 2.0 eq.) was added to the reaction system in batches at 0 °C and the mixture was stirred at room temperature overnight. The completion of the reaction was confirmed by liquid chromatography-mass spectrometry (LC-MS) analysis. The reaction mixture was poured into ice water and extracted with ethyl acetate (EtOAc, 50 mL x 2). The combined organic phases were washed sequentially with saturated sodium sulfite (Na2SO3, 20 mL × 2) aqueous solution and brine (20 mL × 2), and concentrated after drying with anhydrous sodium sulfate (Na2SO4) to obtain the target product 4-chloro-3-iodo-1H-indazole (2.7 g, 9.7 mmol, yield: 87%).LC/MS analysis showed that the molecular ion peak (M+) had a m/z was 279.

References

[1] Patent: WO2012/65062, 2012, A1. Location in patent: Page/Page column 122-123
[2] Patent: WO2015/25025, 2015, A1. Location in patent: Page/Page column 166; 167
[3] Patent: WO2014/28589, 2014, A2. Location in patent: Page/Page column 76

4-CHLORO-3-IODO (1H)INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-CHLORO-3-IODO (1H)INDAZOLE Suppliers

China 44 India 2 United Kingdom 2 United States 5 Global 53

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 86(512)5235 8471 17715136450
Fax: 86(512)5235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 4169
Advantage: 58

Shanghai Devinchem Ltd

Tel: 027-65318838 13646286950
Email: sales@devinchem.com
Country: China
ProdList: 2953
Advantage: 58

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9274
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Nanjing KaiMubo Pharmaceutical Co., Ltd.

Tel: 025-66162170
Fax: 025-66162170
Country: China
ProdList: 7181
Advantage: 55

Yantai ShengKailun Chemical Technology Co., Ltd.

Tel: 13356901049
Fax: QQ：1025383091
Email: 3119594100@qq.com
Country: China
ProdList: 7964
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

518990-33-5, 4-CHLORO-3-IODO (1H)INDAZOLERelated Search:

4-CHLORO-3-IODO-7-METHOXY (1H)INDAZOLE 4-CHLORO-3-IODO (1H)INDAZOLE 4,7-DICHLORO-3-IODO (1H)INDAZOLE 4,6-DICHLORO-3-IODO-1H-INDAZOLE 4-CHLORO-6-METHOXY-3-IODO-1H-INDAZOLE 4-CHLORO-3-IODO-1-METHYL-1H-INDAZOLE 7-AMINO-4-CHLORO-3-IODO INDAZOLE 4-CHLORO-6-HYDROXY-3-IODO (1H)INDAZOLE 4-CHLORO-3-IODO-6-METHYL-(1H)INDAZOLE 4-CHLORO-7-FLUORO-3-IODO (1H)INDAZOLE 4-CHLORO-6-FLUORO-3-IODOINDAZOLE 7-BROMO-4-CHLORO-3-IODO (1H)INDAZOLE 6-BROMO-4-CHLORO-3-IODO (1H)INDAZOLE 4-CHLORO-3-IODO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER 4-CHLORO-3-IODO-7-NITRO INDAZOLE 4-CHLORO-3-IODO-6-INDAZOLECARBOXYLIC ACID 4-CHLORO-3,6-DIIODO (1H)INDAZOLE 4-CHLORO-3-IODO-6-NITRO-1H-INDAZOLE

4-CHLORO-3-IODO (1H)INDAZOLE

4-CHLORO-3-IODOINDAZOLE

4-chloro-3-iodo-1H-indazole(SALTDATA: FREE)

1H-Indazole, 4-chloro-3-iodo-

SKL525

518990-33-5