ChemicalBook > CAS DataBase List > 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER

2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER

Product Name: 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER
CAS No.: 415697-08-4
Chemical Name: 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER
Synonyms: SN-6;SN-6;SN6;SN 6;SN 6, 10 mM in DMSO;inhibit,SN 6,Na+/Ca2+ Exchanger,SN-6,Inhibitor;Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate;2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER;4-Thiazolidinecarboxylic acid, 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-, ethyl ester
CBNumber: CB4690807
Molecular Formula: C20H22N2O5S
Formula Weight: 402.46
MOL File: 415697-08-4.mol

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2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER Property

Boiling point:: 581.2±50.0 °C(Predicted)
Density: 1.285±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO : 62.5 mg/mL (155.29 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 6.63±0.60(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1937
Product name: SN-6
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $94.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1937
Product name: SN-6
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $381
Updated: 2025/07/31

Tocris

Product number: 2184
Product name: SN-6
Purity: ≥99%(HPLC)
Packaging: 50
Price: $818
Updated: 2021/12/16

Tocris

Product number: 2184
Product name: SN-6
Purity: ≥99%(HPLC)
Packaging: 10
Price: $195
Updated: 2021/12/16

TRC

Product number: S589850
Product name: SN6
Packaging: 10mg
Price: $135
Updated: 2021/12/16

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2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Uses

SN 6 is an inhibitor of Na+/Ca+ exchanger (NCX). NCX inhibitors can ameliorate cardiac ischemia-reperfusion injury and promote high-frequency fatigue of skeletal muscle. Inhibitor of bafilomycin A1-induced expression of cyclooxygenase (COX-2).

Biological Activity

Selective Na + /Ca 2+ -exchange (NCX) inhibitor; displays some selectivity for NCX1. IC 50 values are 2.9, 16 and 8.6 μ M for inhibition of intracellular Na+-dependent 45 Ca 2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC 50 = 18 μ M) but minimal activity against NCKX2 and various receptors and ion channels (IC 50 > 30 μ M). Preferentially blocks Ca 2+ influx mode and is more selective for NCX isoforms than KB-R7943 (2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate ). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC 50 = 0.63 μ M).

storage

Desiccate at +4°C

2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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415697-08-4, 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTERRelated Search:

2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER 2-BENZYL-THIAZOLIDINE-4-CARBOXYLIC ACID methyl 2-{[2-(4-methoxyphenyl)ethyl]amino}acetate

SN-6

2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER

SN-6;SN6;SN 6

4-Thiazolidinecarboxylic acid, 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-, ethyl ester

Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate

inhibit,SN 6,Na+/Ca2+ Exchanger,SN-6,Inhibitor

SN 6, 10 mM in DMSO

415697-08-4

Ion transporter and other ion channel