3-AMINO-ISONICOTINIC ACID ETHYL ESTER
- Product Name
- 3-AMINO-ISONICOTINIC ACID ETHYL ESTER
- CAS No.
- 14208-83-4
- Chemical Name
- 3-AMINO-ISONICOTINIC ACID ETHYL ESTER
- Synonyms
- 3-amino-4-pyridinecarboxyL;Ethyl3-Aminoisonicotinate>3-Amino-isonicotinic acid ethyl;ethyl 3-aMinopyridin-4-carboxylate;Ethyl3-amino-4-pyridinecarboxylate;ETHYL 3-AMINOPYRIDINE-4-CARBOXYLATE;3-AMINO-ISONICOTINIC ACID ETHYL ESTER;Ethyl 3-aminoisopyridin-3-carboxylate;3-Amino-isonicotinic acid ethyl ester ,98%;Ethyl 3-aminoisonicotinate, CAS 14208-83-4
- CBNumber
- CB4733551
- Molecular Formula
- C8H10N2O2
- Formula Weight
- 166.18
- MOL File
- 14208-83-4.mol
3-AMINO-ISONICOTINIC ACID ETHYL ESTER Property
- Melting point:
- 170-175
- Boiling point:
- 304.0±22.0 °C(Predicted)
- Density
- 1.192±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 4.13±0.18(Predicted)
- color
- Light orange to Yellow to Green
- CAS DataBase Reference
- 14208-83-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-45
- Hazard Note
- Irritant
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E1137
- Product name
- Ethyl 3-Aminoisonicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- E1137
- Product name
- Ethyl 3-Aminoisonicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $152
- Updated
- 2025/07/31
- Product number
- 4H58-1-V1
- Product name
- Ethyl 3-aminoisonicotinate
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 071971
- Product name
- Ethyl 3-amino-4-pyridinecarboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- A824
- Product name
- Ethyl 3-Aminoisonicotinate
- Packaging
- 5g
- Price
- $49
- Updated
- 2021/12/16
3-AMINO-ISONICOTINIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
Off-white powder or chunks solid
Uses
3-Amino-isonicotinic Acid Ethyl Ester acts as a reagent for the synthetic preparation of heteroaryl compounds as PDE-10 inhibitors useful in treatment and prevention of CNS, metabolic and other diseases. Also in the design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.
Synthesis
64-17-5
7579-20-6
14208-83-4
To ethanol (20 mL) was added 3-aminoisonicotinic acid (1.4 g, 10 mmol) and stirred until completely dissolved. Concentrated sulfuric acid (2.94 g, 30 mmol) was added slowly and the reaction was heated to reflux for 20 hours. After completion of the reaction, ethanol was removed by distillation under reduced pressure. To the residue, water was added and the pH was adjusted to 8-9 with 2 N sodium hydroxide solution under cooling in an ice bath. the precipitated solid was filtered and dried to give ethyl 3-aminoisonicotinate (0.70 g, 42% yield). The filtrate was extracted with ethyl acetate, the organic phase was washed sequentially with water and saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give additional ethyl 3-aminoisonicotinate (0.30 g, 18% yield). The product was characterized by 1H-NMR (DMSO-d6): δ 1.30 (3H, t, J = 7.1 Hz), 4.28 (2H, q, J = 7.1 Hz), 6.66 (2H, br.s), 7.45 (1H, d, J = 5.2 Hz), 7.73 (1H, d, J = 5.2 Hz), 8.23 (1H, s).
References
[1] Australian Journal of Chemistry, 1993, vol. 46, # 7, p. 987 - 993
[2] Patent: EP1844768, 2007, A1. Location in patent: Page/Page column 29-30
[3] Journal of Organic Chemistry, 1952, vol. 17, p. 547,553
[4] Bulletin de la Societe Chimique de France, 1992, # 1, p. 79 - 84
[5] Journal of Medicinal Chemistry, 1993, vol. 36, # 18, p. 2676 - 2688
3-AMINO-ISONICOTINIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
3-AMINO-ISONICOTINIC ACID ETHYL ESTER Suppliers
- Tel
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- Country
- France
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View Lastest Price from 3-AMINO-ISONICOTINIC ACID ETHYL ESTER manufacturers
- Product
- 3-AMINO-ISONICOTINIC ACID ETHYL ESTER 14208-83-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30
- Product
- 3-Amino-isonicotinic acid ethyl ester 14208-83-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.0%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- 3-AMINO-ISONICOTINIC ACID ETHYL ESTER 14208-83-4
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-23