ChemicalBook > CAS DataBase List > 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE

4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE

Product Name
4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
CAS No.
20870-77-3
Chemical Name
4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
Synonyms
AKOS 207-07;4-CHLOROOXINDOLE;4-CHLORO-2-OXINDOLE;4-Chloro-2-oxoindole;4-chloroindolin-2-one;4-Chloroindoline-2-one;4-Chloro-1H-indol-2(3H)-one;4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE;4-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE;4-chloro-2,3-dihydro-1H-indol-2-one
CBNumber
CB4740285
Molecular Formula
C8H6ClNO
Formula Weight
167.59
MOL File
20870-77-3.mol
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4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Property

Melting point:
206-208°
Boiling point:
340.3±42.0 °C(Predicted)
Density 
1.362±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
powder
pka
13.27±0.20(Predicted)
color 
yellow
InChI
InChI=1S/C8H6ClNO/c9-6-2-1-3-7-5(6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
InChIKey
XNSPDJAXCBZCRV-UHFFFAOYSA-N
SMILES
N1C2=C(C(Cl)=CC=C2)CC1=O
CAS DataBase Reference
20870-77-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C380803
Product name
4-Chloroindolin-2-one
Packaging
100mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
044887
Product name
4-Chloro-1,3-dihydro-2H-indol-2-one
Purity
95+%
Packaging
1g
Price
$37
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-5-X9
Product name
4-Chloro-2-oxindole
Packaging
1g
Price
$42
Updated
2021/12/16
AK Scientific
Product number
W4375
Product name
4-Chloroindolin-2-one
Packaging
1g
Price
$93
Updated
2021/12/16
Matrix Scientific
Product number
044887
Product name
4-Chloro-1,3-dihydro-2H-indol-2-one
Purity
95+%
Packaging
5g
Price
$129
Updated
2021/12/16
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4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Chemical Properties,Usage,Production

Synthesis

6344-05-4

20870-77-3

The general procedure for the synthesis of 4-chloro-2-oxoindole (4-chloroindolone) from 4-chloroindoline-2,3-dione was as follows: titanium tetrachloride (TiCl4) (0.7 mL, 6 mmol) was slowly added to a stirring suspension of zinc powder (0.78 g, 12 mmol) in freshly distilled anhydrous THF (15 mL) at room temperature and under dry nitrogen atmosphere. After addition, the mixture was refluxed for 2 hours. After the formed suspension of low-valent titanium reagent was cooled, a THF (10 mL) solution of indigo red or its derivative (2 mmol) was added dropwise. The reaction mixture was stirred at room temperature for about 5 min under nitrogen protection. After confirming the completion of the reaction by thin layer chromatography (TLC) analysis, the reaction was quenched with 3% hydrochloric acid (15 mL) and subsequently extracted with chloroform (3 x 50 mL). The organic phases were combined, washed with water (3 x 50 mL) and dried over anhydrous sodium sulfate. After concentration of the solvent under reduced pressure, the crude product was purified by column chromatography (petroleum ether/ethyl acetate = 5:1) to afford the target compound 4-chloro-2-oxindole (4-chloroindolone).

References

[1] Tetrahedron Letters, 2014, vol. 55, # 14, p. 2238 - 2242

4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Suppliers

China 93 Germany 1 India 1 United Kingdom 4 United States 17 Global 116
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Key Organics Limited/Bionet Research
Tel
--
Fax
--
Email
enquiries@keyorganics.ltd.uk
Country
United Kingdom
ProdList
6663
Advantage
50
Atlantic Research Chemicals Ltd.
Tel
--
Fax
--
Email
info@atlantic-chemicals.com
Country
United Kingdom
ProdList
5618
Advantage
63
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
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View Lastest Price from 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE manufacturers

Chemwill Asia Co.,Ltd.
Product
4-Chloro-2-oxindole 4-Chloro-1,3-dihydro-indol-2-one in stock Factory 20870-77-3
Price
US $1.00/kg
Min. Order
1kg
Purity
High quality purified Factory in China
Supply Ability
Top 3 production capacity Factory
Release date
2019-04-03
Career Henan Chemical Co
Product
4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE 20870-77-3
Price
US $5.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-12

20870-77-3, 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONERelated Search:

4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE 4-CHLOROISATIN 4,6-DICHLORO-1H-INDOLE-2,3-DIONE 5-CHLORO-1,3-DIHYDRO-INDOL-2-ONE 4,7-Dichloroisatin 4-Chloro-7-methylisatin 6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Oxindole 4-Chloroindoline 4,5-DICHLORO-1H-INDOLE-2,3-DIONE 4-CHLORO-5-METHYLISATIN 4-CHLORO-7-METHOXY ISATIN 1-ACETYL-4,6-DICHLORO-1H-INDOLE-2,3-DIONE 4,5,7-trichloro-1H-indole-2,3-dione 3,3-DIBROMO-6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE 4-CHLORO-5-ETHYLISATIN 4-CHLORO-3-(4-HYDROXY-BENZYLIDENE)-1,3-DIHYDRO-INDOL-2-ONE BUTTPARK 80\07-01

  • 4-chloro-2,3-dihydro-1H-indol-2-one
  • 4-Chloro-2-oxindole 4-Chloro-1,3-dihydro-indol-2-one in stock Factory
  • 4-CHLOROOXINDOLE
  • 4-CHLORO-2-OXINDOLE
  • 4-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE
  • 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
  • AKOS 207-07
  • 4-Chloro-2-oxoindole
  • 4-Chloro-1H-indol-2(3H)-one
  • 4-Chloro-2,3-dihydro-1H-indole-2-one
  • 4-Chloroindoline-2-one
  • 4-chloroindolin-2-one
  • 4-Chloro-1,3-dihydro-2H-indol-2-one, 4-Chloroindolin-2-one
  • 2H-Indol-2-one, 4-chloro-1,3-dihydro-
  • 20870-77-3
  • Halides
  • Pyrroles & Indoles