Bcl-2/Bcl-xl inhibitor 1

Product Name: Bcl-2/Bcl-xl inhibitor 1
CAS No.: 2180923-05-9
Chemical Name: Bcl-2/Bcl-xl inhibitor 1
Synonyms: APG-2575;Lisaftoclax;Lisaftoclax (APG-2575;APG-2575 (lisaftoclax);Bcl-2/Bcl-xl inhibitor 1;Lisaftoclax, 10 mM in DMSO;APG-2575 (lisaftoclax) ，S9970;(S)-N-((4-(((1,4-Dioxan-2-yl)methyl)amino)-3-nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)benzamide;Benzamide, 4-[4-[[6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]-1-piperazinyl]-N-[[4-[[(2S)-1,4-dioxan-2-ylmethyl]amino]-3-nitrophenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-
CBNumber: CB48054324
Molecular Formula: C45H48ClN7O8S
Formula Weight: 882.42
MOL File: 2180923-05-9.mol

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Bcl-2/Bcl-xl inhibitor 1 Property

Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 4.07±0.10(Predicted)
form: Solid
color: Light yellow to yellow
InChIKey: FNBXDBIYRAPDPI-BHVANESWSA-N
SMILES: C(NS(C1=CC=C(NC[C@H]2COCCO2)C([N+]([O-])=O)=C1)(=O)=O)(=O)C1=CC=C(N2CCN(CC3CCC4(CCC4)CC=3C3=CC=C(Cl)C=C3)CC2)C=C1OC1=CN=C2NC=CC2=C1

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Hazard and Precautionary Statements (GHS)

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Bcl-2/Bcl-xl inhibitor 1 Chemical Properties,Usage,Production

Uses

Lisaftoclax (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively[1].

IC 50

Bcl-2: 2 nM (IC₅₀); Bcl-xL: 5.9 nM (IC₅₀)

References

[1] WANG, Chia, et al. N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS. Patent. WO2018027097A1.

Bcl-2/Bcl-xl inhibitor 1 Preparation Products And Raw materials

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2180923-05-9, Bcl-2/Bcl-xl inhibitor 1Related Search:

Bcl-2/Bcl-xl inhibitor 1

Lisaftoclax

APG-2575

APG-2575 (lisaftoclax)

Lisaftoclax (APG-2575

Benzamide, 4-[4-[[6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]-1-piperazinyl]-N-[[4-[[(2S)-1,4-dioxan-2-ylmethyl]amino]-3-nitrophenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-

(S)-N-((4-(((1,4-Dioxan-2-yl)methyl)amino)-3-nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)benzamide

Lisaftoclax, 10 mM in DMSO

APG-2575 (lisaftoclax) ，S9970

2180923-05-9