ChemicalBook > CAS DataBase List > Bcl-2/Bcl-xl inhibitor 1

Bcl-2/Bcl-xl inhibitor 1

Product Name
Bcl-2/Bcl-xl inhibitor 1
CAS No.
2180923-05-9
Chemical Name
Bcl-2/Bcl-xl inhibitor 1
Synonyms
APG-2575;Lisaftoclax;Lisaftoclax (APG-2575;APG-2575 (lisaftoclax);Bcl-2/Bcl-xl inhibitor 1;Lisaftoclax, 10 mM in DMSO;APG-2575 (lisaftoclax) ，S9970;(S)-N-((4-(((1,4-Dioxan-2-yl)methyl)amino)-3-nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)benzamide;Benzamide, 4-[4-[[6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]-1-piperazinyl]-N-[[4-[[(2S)-1,4-dioxan-2-ylmethyl]amino]-3-nitrophenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-
CBNumber
CB48054324
Molecular Formula
C45H48ClN7O8S
Formula Weight
882.42
MOL File
2180923-05-9.mol
More
Less

Bcl-2/Bcl-xl inhibitor 1 Property

Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
pka
4.07±0.10(Predicted)
form 
Solid
color 
Light yellow to yellow
InChIKey
FNBXDBIYRAPDPI-BHVANESWSA-N
SMILES
C(NS(C1=CC=C(NC[C@H]2COCCO2)C([N+]([O-])=O)=C1)(=O)=O)(=O)C1=CC=C(N2CCN(CC3CCC4(CCC4)CC=3C3=CC=C(Cl)C=C3)CC2)C=C1OC1=CN=C2NC=CC2=C1
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

Bcl-2/Bcl-xl inhibitor 1 Chemical Properties,Usage,Production

Uses

Lisaftoclax (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively[1].

IC 50

Bcl-2: 2 nM (IC50); Bcl-xL: 5.9 nM (IC50)

References

[1] WANG, Chia, et al. N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS. Patent. WO2018027097A1.

Bcl-2/Bcl-xl inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Bcl-2/Bcl-xl inhibitor 1 Suppliers

China 25 United States 3 Global 28
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58

2180923-05-9, Bcl-2/Bcl-xl inhibitor 1Related Search:


  • Bcl-2/Bcl-xl inhibitor 1
  • Lisaftoclax
  • APG-2575
  • APG-2575 (lisaftoclax)
  • Lisaftoclax (APG-2575
  • Benzamide, 4-[4-[[6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]-1-piperazinyl]-N-[[4-[[(2S)-1,4-dioxan-2-ylmethyl]amino]-3-nitrophenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-
  • (S)-N-((4-(((1,4-Dioxan-2-yl)methyl)amino)-3-nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)benzamide
  • Lisaftoclax, 10 mM in DMSO
  • APG-2575 (lisaftoclax) ，S9970
  • 2180923-05-9