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Pam3Cys-Ser-(Lys)4 TFA

Product Name
Pam3Cys-Ser-(Lys)4 TFA
CAS No.
112208-01-2
Chemical Name
Pam3Cys-Ser-(Lys)4 TFA
Synonyms
Pam3CSK4 TFA;Pam3Cys-Ser-(Lys)4 TFA;Pam3CSK4 TFA (112208-00-1 free base);S-(2,3-Bis(palmitoyloxy)propyl)-N-palmitoyl-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine tri(trifluoroacetate salt);Pam3CSK4 TFA (112208001 free base),Pam3CSK4,Toll-like Receptor (TLR),Pam-3CSK4 TFA (112208-00-1 free base),Inhibitor,inhibit,Pam3CSK4 TFA (112208 00 1 free base)
CBNumber
CB48054874
Molecular Formula
C83H157F3N10O15S
Formula Weight
1624.28
MOL File
112208-01-2.mol
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Pam3Cys-Ser-(Lys)4 TFA Property

storage temp. 
-20°C, away from moisture
solubility 
DMSO : ≥ 50 mg/mL (26.99 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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Pam3Cys-Ser-(Lys)4 TFA Chemical Properties,Usage,Production

Uses

Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2[1].

in vivo

Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice[3].

Animal Model:Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2tm1Kir/J (TLR2 -deficient) mice[3]
Dosage:5 mg/kg
Administration:Intraperitoneally (i.p.); once a day for 9 days
Result:After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12.

IC 50

TLR1; TLR2

References

[1] Irvine KL, et al. The molecular basis for recognition of bacterial ligands at equine TLR2, TLR1 and TLR6. Vet Res. 2013 Jul 4;44:50. DOI:10.1186/1297-9716-44-50
[2] Chen Y, et al. TLR2 agonist Pam3CSK4 enhances the antibacterial functions of GM-CSF induced neutrophils to methicillin-resistant Staphylococcus aureus. Microb Pathog. 2019 May;130:204-212. DOI:10.1016/j.micpath.2019.02.030
[3] Du X, et al. Systemic stimulation of TLR2 impairs neonatal mouse brain development. PLoS One. 2011 May 6;6(5):e19583. DOI:10.1371/journal.pone.0019583

Pam3Cys-Ser-(Lys)4 TFA Preparation Products And Raw materials

Raw materials

Preparation Products

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Pam3Cys-Ser-(Lys)4 TFA Suppliers

China 27 United States 3 Global 30
TargetMol Chemicals Inc.
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MedChemExpress
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112208-01-2, Pam3Cys-Ser-(Lys)4 TFARelated Search:


  • Pam3CSK4 TFA
  • Pam3Cys-Ser-(Lys)4 TFA
  • Pam3CSK4 TFA (112208-00-1 free base)
  • Pam3CSK4 TFA (112208001 free base),Pam3CSK4,Toll-like Receptor (TLR),Pam-3CSK4 TFA (112208-00-1 free base),Inhibitor,inhibit,Pam3CSK4 TFA (112208 00 1 free base)
  • S-(2,3-Bis(palmitoyloxy)propyl)-N-palmitoyl-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine tri(trifluoroacetate salt)
  • 112208-01-2